560C VITAMINS & MINERALS Flashcards
Which of the carotenoid pigments has the greatest vitamin A activity?
a. delta-carotene
b. beta-carotene
c. alpha-carotene
d. gamma-carotene
b. beta carotene
In what cells will you find most of the retinol and vitamin A stored?
a. stellate
b. antrum
c. fundus
d. gallbladder
a. stellate
Formation of retinol from beta-carotene requires the presence of what B vitamin?
a. ascorbic acid
b. folic acid
c. pyridoxal phosphate
d. niacin
d. niacin
Which vitamin directs cellular differentiation of epithelial cells?
a. vitamin E
b. riboflavin
c. vitamin K
d. vitamin A
vitamin A
Which vitamin is said to be essential for reproductive processes and immune system function?
a. D
b. A
c. K
d. E
A
Which is the strongest antioxidant?
a. alpha-tocopherol
b. beta-cryptoxanthin
c. beta-carotene
d. lycopene
d. lycopene
Which micromineral deficiency interferes with vitamin A metabolism by reducing retinol binding protein?
a. zinc
b. selenium
c. iron
d. manganese
a. zinc
Which vitamin is believed to function like a steroid hormone?
a. choline
b. vitamin A
c. vitamin D
d. vitamin E
Vitamin D
Which vitamin has as its primary function the maintenance of calcium homeostasis?
a. A
b. K
c. D
d. E
C. D
What vitamin is associated with diminished proliferation and enhanced differentiation of cells, which serves as a basis for its use as treatment of skin diseases such as psoriasis?
a. D
b. K
c. A
d. E
A. D
A deficiency of which vitamin is commonly associated with rickets?
a. D
b. K
c. A
d. E
D
Toxicity of which vitamin is related to increased deposition of calcium in soft tissues?
a. D
b. biotin
c. E
d. lipoic acid
D
Which tocopherol form provides the most vitamin E activity in the U.S. food supply?
a. alpha
b. delta
c. beta
d. gamma
alpha
Which fat-soluble vitamin has as its principal function the maintenance of membrane integrity?
a. vitamin D
b. vitamin E
c. vitamin K
d. vitamin A
vitamin E
In what type of tissue is the largest amount of vitamin E stored?
a. heart
b. brain
c. lung
d. adipose
adipose
Formation of retinol from beta-carotene requires the presence of what B vitamin?
a. ascorbic acid
b. folic acid
c. pyridoxal phosphate
d. niacin
d. niacin
Which vitamin directs cellular differentiation of epithelial cells?
a. vitamin E
b. riboflavin
c. vitamin K
d. vitamin A
d. vitamin A
Which is the strongest antioxidant?
a. alpha-tocopherol
b. beta-cryptoxanthin
c. beta-carotene
d. lycopene
d. lycopene
Which micromineral deficiency interferes with vitamin A metabolism by reducing retinol binding protein?
a. zinc
b. selenium
c. iron
d. manganese
a. zinc
Which compound is associated with less oxidized LDL and less risk of development of foam cells and atherosclerotic lesions?
a. alpha -tocopherol
b. hydroquinone
c. calcidiol
d. Vitamin D
alpha-tocopherol
Which vitamin is associated with improved plasma membrane structure and glucose transport/metabolic control in people with type 2 diabetes?
a. A
b. D
c. E
d. K
E
For which vitamin is the tolerable upper intake level set because of increased tendency for bleeding?
a. A
b. E
c. K
d. D
E
Which of the fat-soluble vitamins is consumed in the form of phylloquinone from plant foods?
a. E
b. K
c. A
d. D
K
Which fat-soluble vitamin appears to operate as a coenzyme that modifies proteins to bind with calcium?
a. ß-carotene
b. A
c. K
d. E
K
Vitamin K deficiency is most often observed in:
a. children
b. newborns
c. old people
d. adolescents
Newborns
Vitamin K deficiency in adults is most likely due to:
a. high-fiber diet
b. antibiotic therapy
c. oxalic acid in food
d. achlorhydria
B
For which vitamin is a severe deficiency associated with an increased tendency for bleeding?
a. E
b. A
c. K
d. D
C. K
Which is not a function of vitamin A.?
a. vision
b. cellular energy
c. bone development
d. reproduction
B. Cellular energy
Vitamin A is needed for T-lymphocyte function and for antibody response to viral, parasitic and bacterial infection?
a. True
b. False
T
Carotenoids like Lutein and Zeaxanthin are found in the macula and can induce oxidation of cell membranes and can exacerbate UV-induced eye damage?
a. True
b. False
F
Excess Vitamin A interferes with Vitamin K absorption?
a. True
b. False
T
Vitamin A deficiency is associated with decreased iron incorporation into RBC’s, and supplementation with it in turn corrects the anemia?
a. True
b. False
T
Nuclear receptors for Vitamin D are only found on bone despite claims that they are found in over 30 organs such as intestine, skin, lung, muscle, and kidney?
a. True
b. False
F
RANKL is located on the osteoclast?
a. True
b. False
F
In adults Vitamin D deficiency results in rickets?
a. True
b. False
F
Vitamin D is conditionally essential in the elderly, alcoholics, and for people living in the north-east?
a. True
b. False
T
Olive oil is high in Alpha-Tocopherol?
a. True
b. False
T
If a patient is a smoker, exercises, and takes PUFA’s, it would be a good idea for this individual to supplement with _____ to avoid lipid peroxidation?
a. Vitamin A
b. Vitamin K
c. Vitamin D
d. Vitamin E
D vitamin e
Bacteria in the colon, provide a source of ______ for humans.
a. menaquinones
b. phylloquinone
c. calcitriol
d. lycopene
menaquinones
To clot, fibrinogen must be converted to its active form of fibrin by?
a. vitamin E
b. vitamin K and calcium
c. vitamin K
d. vitamin D
B. vitamin K and calcium
All of the following can be involved with osteoporosis except for?
a. Vitamin K
b. Vitamin D
c. Vitamin A
d. Vitamin E
Vitamin E
Where is the primary site for conversion of pro-vitamin A to vitamin A in the human body?
a. Adipose cell
b. chylomicron
c. liver
d. intestinal lumen
e. intestinal mucosal cell
intestinal mucosal cell
Calcitriol can be defined as
a. a fully activated form of vitamin D
b. synthetic vitamin D2 available commercially
c. vitamin D3 produced in the skin
d. the most abundant form of vitamin D in the blood
e. a precursor to pre-vitamin D3
A fully activated form of vitamin D
Which of the following foods are high in vitamin D because they are typically fortified?
a. milk
b. orange juice
c. cheese
d. fish
e. butter
milk
How many vitamers of vitamin E are there?
a. 2 vitamers, D and L
b. 4 vitamers, alpha, beta, delta, gamma
c. 8 vitamers, including tocopherols and tocotrienols
d. 12 vitamers, including acetate and succinate esters
e. 1 vitamer
8 vitamers, including tocopherols and tocotrienols
Which TWO of the following depend upon vitamin K for their production?
a. prostaglandin F2-alpha
b. calcitonin
c. matrix Gla protein
d. osteocalcin
e. 7-dehydrocholesterol
matrix Gla protein & osteocalcin
Which of the following blood disorders is associated with vitamin K deficiency?
a. macrocytic anemia
b. hemolytic anemia
c. venous thrombosis
d. hemorrhagic disease
e. microcytic anemia
hemorrhagic disease
___________________occurs with vitamin A deficiency and is characterized by abnormalities of the conjunctiva and cornea of the eye.
a. Hypocarotenosis
b. Myopia
c. Night blindness
d. Xerophthalmia
e. Transcaltachia
D. Xerophthalmia
The naturally occurring form of vitamin K which is thought to provide the majority of vitamin K in the U.S. diet is __________________ found in plant foods.
a. Menadione
b. Decaquinones
c. Menaquinone
d. Phylloquinone
e. Hydroquinones
D. Phylloquinone
The vitamin K-dependent factors required for the normal coagulation of blood are:
a. Factors V, X
b. Factors V, VIII
c. Factors II (prothrombin), VII, IX, and X
d. Factors V, VII, IX, and X
e. Factors V, VIII, IX
C. Factors II (prothrombin), VII, IX, and X
Two anticoagulant drugs that antagonize the action of vitamin K are:
a. Coumarin and Vioxx
b. Coumarin and warfarin
c. Coumarin and Actonel
d. Warfarin and Actonel
e. Warfarin and Vioxx
B. Coumarin and warfarin
Excess amounts of Vitamins __ has been associated with birth defects as a drug knows as Accutane(for acne treatment) caused (which is a modified form of this vitamin).
a. vitamin E
b. vitamin A
c. vitamin K
d. vitamin D
B. vitamin A
Choose the food that is high in vitamin A palmitate
a. pumpkin
b. spinach
c. carrots
d. liver
D. Liver
The majority of vitamin A is stored in the liver, while carotenoids are stored mainly in the _____ tissue.
a. adipose
b. eye
c. muscle
d. skin
A. Adipose
Which of the following is needed for the visual cycle?
a. 11-cis retinal
b. 9-cis retinoic acid
c. cryptoxanthin
d. lycopene
A.
Would you recommend β-carotene supplementation to a smoker to decrease risk to lung cancer?
a. No—β-carotene supplements may be harmful to smokers and are their use is not advised for the general public
b. Yes—β-carotene can quench singlet oxygen
c. Yes—smoking increases free radical formation; β-carotene can decrease free radicals
d. No—β-carotene supplements can cause a vitamin A toxicity and liver cirrhosis
A. No—β-carotene supplements may be harmful to smokers and are their use is not advised for the general public.
Choose the phrase which best explains the following statement: “β-carotene is no magic bullet.”
a. β-carotene supplements cannot be manufactured cheaply enough
b. β-carotene is not the only health-promoting molecule in fruits and vegetables
c. β-carotene does not decrease the reactivity of singlet oxygen molecules
d. β-carotene can replace vitamin E in terminating the auto-oxidation of fatty acids
B. β-carotene is not the only health-promoting molecule in fruits and vegetables
Which symptom of a vitamin A deficiency is most likely responsible for deficiency-related deaths?
a. severe infections
b. functions as a teratogen
c. keratinization of the cornea
d. poor cellular differentiation and growth
A. Severe infections
magine you are a nutritionist working in a country other than the U.S. Which is an assumption about vitamin D status that is NOT true?
a. The latitude makes a difference as regards how much vitamin D can be self-synthesized
b. Customs of dress make a difference as regards how much vitamin D can be self-synthesized
c. Skin color makes a difference as regards how much sun is needed to synthesize vitamin
d. Cow’s milk is a reliable source of vitamin D in the food supply
D. Cow’s milk is a reliable source of vitamin D in the food supply
Which vitamin D molecule would you expect to see in fortified foods?
a. calcidiol - 25-OH D3
b. calcitriol - 1,25-OH2 D3
c. cholecalciferol - vitamin D3
d. ergocalciferol - vitamin D2
cholecalciferol - vitamin D3
It’s a good thing that milk is fortified with vitamin D so that we can consume the RDA if we drink the recommended number of glasses of milk each day. The DRI for 9-69 year olds is 600 IU (15 mg). This equals _____ cups of milk.
a. four
b. three
c. two
d. six
D. Six
What % of vitamin D from the diet is absorbed?
a. 50
b. 20
c. 30
d. 40
A. 50
Dietary cholecalciferol must be further hydroxylated in order to be active vitamin D. The first hydroxylation occurs in the _____ to produce _____.
a. skin, 7-dehydrocholesterol
b. liver, 25-hydroxycholecalciferol
c. kidney, 1-hydrocholesterol
d. kidney, 25-hydroxycholecalciferol
B.
The RDA for vitamin D for people over the age of 70 is _____ the RDA for teenagers.
a. less than
b. equal to
c. greater than
C. Greater than
If asked about the relationship of vitamin D to autoimmune disease, the best information for a dietetic professional to provide is:
a. some evidence suggests a protective effect of vitamin D
b. take a supplement containing 2000 IU vitamin D each day
c. the evidence is only in animals, not humans
d. the evidence does not support a relationship at this time
A. Some evidence suggests a protective effect of vitamin D
Sun exposure does not cause hypervitaminosis D because _____.
a. sunburned skin is not sensitive to the UV wavelength that causes previtamin D3 synthesis
b. vitamin D-binding protein is not saturated with D3
c. inactive products are synthesized from pre-vitamin D3 and D3
d. cutaneous production of the vitamin reaches a maximum
D. cutaneous production of the vitamin reaches a maximum
What is a symptom of a vitamin D toxicity?
a. rickets
b. hypocalcemia
c. hypercalcemia
d. osteoporosis
C. hypercalcemia
In assessing the vitamin D status of an individual, which measure would you use?
a. circulating cholecalciferol
b. circulating 1,25-OH2 cholecalciferol
c. circulating 25-OH cholecalciferol
d. serum calcium levels
C. circulating 25-OH cholecalciferol
How does alpha-tocopherol differ from beta-tocopherol?
a. location of methyl groups
b. saturation of side chain
c. source in the diet
A. location of methyl groups
A genetic deficiency in _____ leads to a vitamin E deficiency syndrome.
a. alpha-tocopherol transfer protein in the liver
b. gamma-tocotrienol
c. RRR alpha-tocopherol
d. tocopherol carrier protein in the jejunum
alpha-tocopherol transfer protein in the liver
The action of vitamin K is the post-translational synthesis of blood clotting factors occurs:
a. in the liver
b. in the small intestine
c. in the bone marrow
d. in the blood
A. in the liver
Anticoagulant drugs that act by inhibiting vitamin K activity do so by which mechanism?
a. inhibiting the formation of the active form of vitamin K
b. stimulating osteocalcin synthesis
c. interfering with micelle formation so vitamin K is not absorbed
d. not allowing calcium to interact with Gla residues
inhibiting the formation of the active form of vitamin K
Mr. S. takes warfarin due to his valve replacement surgery. He is an avid gardener and enjoys eating the many green leafy vegetables he grows. You caution Mr. S. to tell his physician about this because the amount of warfarin he takes may need to be _____
a. increased
b. decreased
A. Increased
Which is the best measure of vitamin K status?
a. INR
b. des-γ-carboxyglutamic prothrombin
c. prothrombin time
d. PTH concentration
C. prothrombin time
The glucose transporter that is sensitive to insulin is
a. SGLT1
b. GLUT1
c. GLUT4
d. GLUT2
D. Glut 4
Which hormonal changes occur in response to a fall in blood glucose concentration?
a. decreased insulin, increased glucagon
b. increased insulin, decreased glucagon
c. increased insulin, increased glucagon
d. decreased insulin, decreased glucocorticoids
B. decreased insulin, increased glucagon
Glycemic load considers the _____ in the food.
a. fat and carbohydrate content
b. protein and carbohydrate content
c. quantity and quality of carbohydrate
d. fat to carbohydrate ratio
quantity and quality of carbohydrate
Insulin is an anabolic hormone. Which process does insulin stimulate?
a. lipolysis
b. ketogenesis
c. glycogenesis
d. gluconeogenesis
C. glycogenesis
Due to a lack of the enzyme glucose-6-phosphatase, which tissue capable of glycogenesis cannot contribute to blood glucose levels between meals?
a. brain
b. kidney
c. muscle
d. liver
C. Muscle
The major end products of cellular oxidation of carbohydrate include:
a. water, carbon dioxide, and energy
b. carbon, nitrogen, and hydrogen
c. glucose and amino acids
d. dietary fiber and ammonia
A. water, carbon dioxide, and energy
Glycolysis is a process involving:
a. reactions that convert glucose to pyruvate
b. synthesis of fatty acids
c. reactions that convert glucose to glycogen
d. reactions that convert glycogen to protein
A.
In what part of the cell does glycolysis occur?
a. mitochondrion
b. endoplasmic reticulum
c. cytosol
d. nucleus
C.
In which cellular site is most of the energy released when carbohydrates are oxidized to carbon dioxide and water?
a. Golgi body
b. mitochondrion
c. reticuloendothelium
d. cytoplast
mitochondrion
Two hormones that stimulate glycogenolysis in the muscle and liver, respectively, are _____.
a. insulin and epinephrine
b. cortisol and epinephrine
c. epinephrine and glucagon
d. glucagon and insulin
epinephrine and glucagon
In what organelle are the enzymes that catalyze the citric acid cycle located?
a. lysosome
b. cytoplasmic matrix
c. mitochondrion
d. endoplasmic reticulum
mitochondrion
Under anaerobic conditions within a cell, how many net ATPs are formed from one glucose molecule by substrate-level phosphorylation?
a. two
b. six
c. four
d. none
two
Under anaerobic conditions within a cell, how many net ATPs are formed from one glucose molecule by substrate-level phosphorylation?
a. two
b. six
c. four
d. none
A.
In the complete oxidation of 1 mol of glucose, how many ATPs are formed?
a. 4-6
b. 32-38
c. 8-12
d. 18-24
32-38
During the end reaction of the electron transport chain, molecular oxygen becomes _____.
a. reduced to water
b. FADH2
c. oxidized to carbon dioxide
d. NADH+ H+
A. reduced to water
Gluconeogenesis is essentially the reversal of which pathway?
a. glycolysis
b. TCA cycle
c. lipogenesis
d. glycogenesis
A. Glycolysis
Muscle lactate is converted to glucose in the liver and returned to the muscle by means of the _____.
a. electron transport chain
b. malate-aspartate shuttle
c. Cori cycle
d. pentose phosphate pathway
C. Cori cycle
Within the lamina propria, lying just below the epithelium, is the mucosa-associated lymphoid tissue, which
a. initiates peristalsis
b. contains white blood cells and protects against ingested microorganisms
c. controls secretions from the mucosal glands
d. secretes mucus, hormones and digestive juices into the lumen
B. Contains white blood cells and protects against ingested microorganisms.
Which of the following is NOT considered an accessory organ?
a. gallbladder
b. liver
c. pancreas
d. spleen
D. Spleen
Bile is most important for the digestion and absorption of _____.
a. proteins
b. vitamins
c. fats
d. carbohydrates
C. Fats
What is the name of the digestive enzyme in saliva that digests starch?
a. amylase
b. synthetase
c. lactase
d. lipase
A. Amylase
Which is NOT a component of saliva?
a. enzymes
b. mucus
c. water
d. proteases
D.
The volume of a normal stomach ranges from 50 mL (~2 oz) when empty to _____ when full.
a. 1.5 L (~ 6 cups)
b. 750 mL (~3 cups)
c. 250 mL (~1 cup)
d. 100 mL (~4 oz)
A.
What product produced by neck cells in the oxyntic gland of the stomach protects the epithelium from mechanical and chemical damage?
a. amylase
b. pepsin
c. mucus
d. gastrin
C. Mucus
What cells found both in oxyntic glands and pyloric glands of the stomach secrete hydrochloric acid and intrinsic factor?
a. enteroendocrine cells
b. neck cells
c. chief cells
d. parietal cells
D. Parietal cells
What cells found in oxyntic glands in the body of the stomach secrete pepsinogens?
a. parietal cells
b. chief cells
c. enteroendocrine cells
d. neck cells
B.
Which specialized cell of the gastric epithelium secretes a hormone?
a. chief cells
b. g-cells
c. neck cells
d. parietal cells
B. G cells
The chief cells secrete _______.
a. mucus
b. zymogens
c. hydrochloric acid
d. gastrin
D. Gastrin
The parietal cells secrete _____.
a. hydrochloric acid and intrinsic factor
b. zymogens and hydrochloric acid
c. intrinsic factor and gastrin
d. gastrin and zymogens
A.
A function of hydrochloric acid in the gastric juice is to
a. protect the stomach lining from damage
b. act as a bactericide agent
c. digest protein, functioning as an endopeptidase
d. inhibit secretion of gastrin and CCK
B.
When the pH of the stomach is increased to avoid GERD, over time the stomach may not be acidic enough. Which of the following might occur?
a. decreased protein digestion
b. destruction of bacteria in the stomach
c. gastric ulcer
d. lack of carbohydrate digestion
A
The product(s) of pepsin’s action is/are _______.
a. hydrolyzed proteins
b. short chain fatty acids
c. amylose
d. disaccharides
A
Pepcid, a drug that is classified as a H2 receptor antagonist, acts by _____.
a. inhibiting the binding of histamine to the parietal cells
b. inhibiting the release of acetylcholine by the vagus nerve
c. inhibiting the secretion of hydrogen ions by the parietal cells
d. inhibiting the binding of gastrin to the parietal cells
A
Which medication inhibits hydrogen release into the gastric juice, which reduces GI mucosal irritation?
a. Nexium
b. Pepcid
c. Tagament
d. Tums
A
Most of the digestive enzymes produced by the intestinal enterocytes function
a. in the stomach
b. within the cytoplasm of the enterocytes
c. in the intestinal lumen
d. at the brush border
D
The pancreas is a digestive system accessory organ with two types of active tissue, the ductless endocrine cells that secrete insulin and glucagon and the
a. erythropoietic cells that produce red blood cells
b. ductless absorptive tissue that controls bicarbonate
c. acinar exocrine cells that produce digestive enzymes
d. liver-like cells that produce bile
acinar exocrine cells that produce digestive enzymes
Pancreatic juice that enters the duodenum through the sphincter of Oddi contains all of the following EXCEPT _____.
a. digestive enzymes
b. cations such as sodium, potassium, and calcium
c. intrinsic factor
d. anions such as bicarbonate and chloride
intrinsic factor
The majority of the pancreatic tissue is _____.
a. exocrine in function
b. endocrine in function
exocrine in function
In what organ are enzymes produced that are responsible for digestion of 50% of carbohydrate and protein and 90% of fat?
a. gallbladder
b. esophagus
c. pancreas
d. liver
pancreas
The hormone whose major action is to alkalize intestinal contents by stimulating secretion of bicarbonate from the pancreas and by inhibiting gastric acid secretion and gastric emptying is _____.
a. cholecystokinin
b. secretin
c. gastrin
d. GRP
secretin
The hormone primarily responsible for contraction of the gallbladder and release of bile into the duodenum is _____.
a. cholecystokinin
b. secretin
c. GRP
d. gastrin
cholecystokinin
Bile salts are synthesized from cholesterol in the _____.
a. canaliculi
b. common bile duct
c. hepatocytes
d. gallbladder
hepatocytes
The total bile acid pool in the human body is 2.5 to 5 g. What percentage of bile is reabsorbed in the ileum?
a. 65%
b. 90%
c. 10%
d. 30%
90%
Which of the following is enterohepatically circulated
a. pancreatic enzymes
b. bile
c. CCK
d. glucose
bile
In general, in which portion of the gastrointestinal tract does most absorption occur?
a. colon
b. esophagus
c. stomach
d. small intestine
small intestine
How long does it take for most of the carbohydrate, protein, and fat to be absorbed from chyme after it enters the small intestine?
a. 30 minutes
b. 1 hour
c. 10 minutes
d. 2 hours
30 minutes
Which of the mechanisms responsible for absorption of nutrients into the epithelial cell of the villus requires energy?
a. diffusion
b. facilitated diffusion
c. glucagon
d. active transport
active transport
Anaerobic bacteria populate the gut in _____ greater quantities than aerobic bacteria
a. 2 fold
b. 10 fold
c. 100 fold
d. 5 fold
10 fold
Of the 3 short-chain fatty acids created by gut bacteria, which one is the preferred energy source for colonic epithelial cells?
a. acetic acid
b. propionic acid
c. butyric acid
d. oleic acid
butyric acid
When diagnosing lactose intolerance, _____ is measured in the breath following oral consumption of 50 g lactose.
a. carbon dioxide
b. methane
c. sulfur
d. hydrogen
Hydrogen
Lactose intolerance is common in all of the following EXCEPT _____.
a. Asian Americans
b. American Indians
c. European Americans
d. African Americas
European Americans
Prebiotics act as substrates for the growth of beneficial bacteria in the colon and are _____.
a. selected fibers
b. certain types of bifidobacteria
c. live cultures of mixed lactobacilli
d. antibiotics
selected fibers
The parasympathetic nervous system affects gastrointestinal motility by
a. constricting sphincters
b. decreasing muscle contractions
c. stimulating peristalsis
d. inhibiting peptide production
stimulating peristalsis
The major role of gastrin in the GI tract is that of _____.
a. stimulation
b. transport
c. inhibition
d. no effect
stimulation
Secretin is released from the enteroendocrine S-cell in the _____.
a. proximal small intestine
b. colon
c. esophagus
d. gastric mucosa
proximal small intestine
Which regulatory peptide synthesized in the pancreatic and intestinal cells appears to inhibit release of gastrin, secretin, and motilin?
a. somatastatin
b. GRP
c. insulin
d. neurotensin
somatastatin
Which of the following peptides stimulates appetite?
a. bombesin
b. leptin
c. cholecystokinin
d. ghrelin
ghrelin
When water-soluble vitamins are consumed in excess of body needs, generally the excess is:
a. not absorbed
b. excreted in the urine
c. excreted in the feces
d. stored in liver, bone, and adipose tissue
excreted in the urine
All of the following are involved in satiety and suppression of food intake EXCEPT _____.
a. corticotropin-releasing hormone
b. cholecystokinin
c. leptin
d. neuropeptide Y
neuropeptide Y
A major function of B vitamins is to serve as:
a. electrolytes
b. a part of a coenzyme
c. antibodies
d. a source of energy
a part of a coenzyme
Which water-soluble vitamin contributes to “intracellular cement” in the formation of scar tissue and wound healing?
a. vitamin B12
b. riboflavin
c. vitamin C
d. thiamin
vitamin C
Which of the following molecules synthesized with the help of vitamin C underscores the importance of vitamin C to fat metabolism?
a. carnitine
b. tyrosine
c. norepinephrine
d. collagen
carnitine
A primary function of vitamin C is to act as an:
a. antiviral agent
b. antioxidant
c. antirachitic agent
d. acyl transferase
antioxidant
A major role for thiamin is:
a. blood coagulation
b. erythrocyte synthesis
c. energy transformation
d. collagen formation
energy transformation
A consequence of thiamin deficiency is:
a. beriberi
b. pellagra
c. rickets
d. megaloblastic anemia
beriberi
Cheilosis is a symptom of a dietary deficiency of which vitamin?
a. ascorbic acid
b. riboflavin
c. biotin
d. niacin
riboflavin
When the diet is adequate in protein, the body can synthesize niacin from which amino acid?
a. valine
b. phenylalanine
c. tyrosine
d. tryptophan
tryptophan
Which vitamin has a reduced coenzyme form important for fatty acid and cholesterol synthesis that is a product of the hexose monophosphate shunt?
a. vitamin C
b. niacin
c. thiamin
d. riboflavin
niacin
Which classical vitamin deficiency is known for the four Ds: dermatitis, dementia, diarrhea, and death?
a. folic acid
b. niacin
c. biotin
d. thiamin
niacin
Which of the water-soluble vitamins is found widely distributed in all plant and animal foods, which makes a deficiency unlikely?
a. thiamin
b. pantothenic acid (B5)
c. riboflavin
d. pyridoxine
pantothenic acid (B5)
Synthesis of coenzyme A starts with the phosphorylation of which vitamin?
a. pyridoxal phosphate
b. vitamin E
c. pantothenic acid
d. folic acid
pantothenic acid (B5)
A deficiency of what vitamin is associated with these symptoms: hallucinations, lethargy, skin rash, alopecia, and muscle pain?
a. vitamin C
b. vitamin B12
c. thiamin
d. biotin
biotin
5-methyl THF requires the action of which vitamin in order to form folate?
a. niacin
b. B12
c. B2
d. C
B12
Folate is vitally important for dividing cells during growth and cancer because of its essential role in the synthesis of _____.
a. purines and pyrimidines
b. lysosomes and peroxisomes
c. lipid bilayers
d. mitochondria
purines and pyrimidines
Intrinsic factor is required for the absorption of which vitamin?
a. C
b. B12
c. B2
d. B6
B12
Which of the water-soluble vitamins is able to be stored and retained in the body for long periods of time?
a. B12
b. thiamin
c. niacin
d. folic acid
B12
Which vitamin is most involved in amino acid metabolism?
a. biotin
b. vitamin E
c. vitamin B6
d. vitamin A
vitamin B6
Metabolism of vitamin B6 to the primary coenzyme form, pyridoxal phosphate, requires the action of what other B-vitamin?
a. THF
b. GSH
c. FMN (flavin mononucleotide; B2)
d. NAD FMN
FMN (flavin mononucleotide; B2)
Because vitamin B6 is involved in heme synthesis, a deficiency symptom is
a. seizures
b. hypochromic, microcytic anemia
c. hyperhomocysteinemia
d. impaired calcium metabolism
hypochromic, microcytic anemia
Which of the following vitamins has a Tolerable Upper Intake Level established?
a. thiamin
b. vitamin B6
c. vitamin B12
d. riboflavin
vitamin B6
Ascorbic acid acts as a pro-oxidant by:
a. reacting with transferrin-bound iron
b. reducing ferrous iron
c. reducing dehydroascorbic acid
d. mobilizing ferric iron from storage
reducing ferrous iron
Elevated homocysteine levels can be due to all the following except:
a. low pyridoxine
b. low ascorbic acid
c. low folacin
d. low cobalamin
low ascorbic acid
Which three vitamins are involved in the synthesis of fatty acids?
a. biotin, vitamin D, thiamin
b. niacin, biotin, pantothenic acid
c. riboflavin, B12, folate
d. thiamin, riboflavin, niacin
niacin, biotin, pantothenic acid
Thiamin deficiency associated with alcoholism is known as:
a. Cirrhosis of the liver
b. Wernicke-Korsakoff Syndrome
c. Pellagra
d. Beriberi
e. Maple Syrup Urine Disease
Werniche-Korsakoff Syndrome
Which of the following would you find under B12-deficient conditions and the methyl trap hypothesis?
a. accumulation of 5-methylene THF
b. accumulation of THF
c. more than one of the above
d. accumulation of 5-methyl THF
e. depletion of homocysteine
accumulation of 5-methyl THF
Which of the following amino acids is a precursor to niacin?
a. phenylalanine
b. tryptophan
c. leucine
d. valine
tryptophan
Niacin toxicity may include all of the following effects except one. Which one?
a. Elevated plasma glucose
b. Liver injury
c. Increased uric acid levels
d. Heartburn
e. Increased blood pressure
increased blood pressure
Which of the following is a potential toxic effect of excess pyridoxine?
a. Kidney stone formation
b. Excessive bleeding
c. Liver damage
d. Peripheral neuropathy
e. Low HDL levels
Peripheral neuropathy
A characteristic that is unique to vitamin B12 is that it requires:
a. intrinsic factor for absorption
b. presence of all other B vitamins to perform its function
c. chromium in its molecular structure
d. lipids for absorption
e. an acid intestinal environment for synthesis
Intrinsic factor for absorption
Which reaction is typical of the kind catalyzed by vitamin C?
a. transamination
b. methylation
c. hydroxylation
d. decarboxylation
e. carboxylation
hydroxylation
Which of the following foods is NOT a good source of vitamin C?
a. carrots
b. brussel sprouts
c. broccoli
d. citrus fruits
e. green pepper
carrots
Hyperhomocysteinemia is associated with an increased risk for heart disease. Research has shown that supplementation with which of the following three vitamins reduces plasma homocysteine concentrations.
a. Vitamin B1, vitamin B12, vitamin D
b. Vitamin B1, vitamin B12, biotin
c. Folate, vitamin B6, vitamin B12
d. Vitamin B1, vitamin E, vitamin K
e. Vitamin B1, vitamin B6, vitamin B12
folate, vitamin B6, vitamin B12
Vitamin C is involved in the synthesis of which of the following. Choose the most inclusive answer.
a. Collagen
b. Carnitine
c. Collagen, carnitine, neurotransmitters
d. Collagen, carnitine
e. Neurotransmitters
collagen, carnitine, neurotransmitters
Pellagra symptoms may appear during B6 deficiency, because it is required in the process of obtaining niacin from tryptophan?
a. True
b. False
True
Pernicious anemia can be due to folate or B12 deficiency?
a. True
b. False
False
High circulating levels of homocysteine (i.e., hyperhomocysteinemia) have been implicated in a number of pathologies including cardiovascular disease?
a. True
b. False
True
The highest amounts of Vitamin C is located in the?
a. WBC
b. adrenal glands
c. heart
d. liver
adrenal glands
The Vitamn C absorption increases with increased vitamin intake?
a. True
b. False
False
Vitamin C is needed for the hydroxylation of ______ in order to synthesize tyrosine.
a. serotonin
b. niacin
c. tryptophan
d. melatonin
e. phenylalanine
phenylalanine
The most common side effect of Vitamin C toxicity is?
a. bleeding gums
b. high cholesterol
c. kidney stones
d. arthralgia
e. abdominal pain and diarrhea
abdominal pain and diarrhea
___ is involved with nerve impulse transmission and regulation of sodium channels and ACH receptors?
a. B1(thiamine)
b. B7
c. B12
d. B5
e. vitamin C
B1 (thiamine)
To recycle Glutathione ___ and ___ are needed.
a. Folic acid
b. biotin
c. pantothenic acid
d. niacin
e. riboflavin
niacin (B3) & riboflavin
Burning feet syndrome is seen with deficiency of?
a. biotin
b. folic acid
c. thiamin
d. pantothenic acid
e. niacin
pantothenic acid (B5)
Methionine regeneration from homocysteine involves?
a. biotin
b. 5-methyl THF
c. thiamin
d. riboflavin
e. vitamin K
5-methyl THF
B12 deficiency can lead to all of the following except for?
a. anemia
b. tinnitus
c. shortness of breath
d. abnormal gait
e. demyelination
tinnitus
Schillings test is used to asses?
a. B6 deficiency
b. Riboflavin levels
c. B12 deficiency related to intrinsic factor
d. Folic acid deficiency
B12 deficiency related to intrinsic factor
To assess B6 deficiency, a tryptophan load of 100mg/kg body weight, and measure the urinary excretion of_______.
a. Xanthurenic acid excretion
b. methionine
c. Intrinsic factor
d. PLP
e. Cysteine
Xanthurenic acid excretion
Lethargy, depression, hallucinations, muscle pain, alopecia, scaly, red dermatitis is seen with deficiency in?
a. vitamin C
b. thiamin
c. riboflavin
d. biotin
biotin
Most animals synthesize their own ascorbic acid from _____.
a. glucose
b. alanine
c. glutamine
d. glycogen
glucose
Without enough vitamin C, collagen would _____.
a. be too tightly coiled
b. too strong and less flexible
c. be under-hydroxylated
d. be over-hydroxylated
be under-hydroxylated
Although excess absorbed ascorbic acid is excreted in urine, the body has an estimated maximal body pool of about _____, which can be maintained with intakes of 100-200 mg vitamin C per day.
a. 500 mg
b. 1000 mg
c. 2000 mg
d. 1500 mg
2000 mg
Vitamin C’s actual participation in biochemical reactions usually involves its antioxidant ability. Choose the description of this activity.
a. Accepts an electron from the quinone form of vitamin E
b. Accepts an electron or electrons to reduce a mineral cofactor
c. Donates an electron or electrons to oxidize a mineral cofactor
d. Donates an electron or electrons to reduce a mineral cofactor
Donates an electron or electrons to reduce a mineral cofactor (Vitamin C recycles Vitamin E)
The necessity of ascorbic acid for its role in _____ is believed to be the reason that people with scurvy have no energy and are very tired.
a. carnitine synthesis
b. creatine synthesis
c. hormone activation
d. collagen synthesis
carnitine synthesis
The RDA for vitamin C for adult men is _____ and the UL is _____.
a. 200 mg, 2000 mg
b. 75 mg, 500 mg
c. 100 mg, 500 mg
d. 90 mg, 2000 mg
90 mg, 2000 mg
Erythrocyte transketolase activity is an assay to assess the status of:
a. thiamin
b. riboflavin
c. B6
d. B12
thiamin
Folate in foods can only be absorbed in the monoglutamate form; therefore, digestive enzymes called _____ are important for folate nutriture.
a. lipases
b. legumes
c. hydrolases
d. conjugases
conjugases
Which of the following reflects long-term folate status?
a. serum folate
b. serum methylmalonic acid
c. homocysteine concentration in blood
d. red blood cell folate
red blood cell folate
To absorb folate consumed from green, leafy vegetables, _____.
a. glutamic acid molecules must be added
b. glutamic acid molecules must be removed
c. glutamate must be transaminated to form alpha-ketoglutarate
d. phosphate groups must be removed by the action of alkaline phosphatase
glutamic acid molecules must be removed
In the enzyme methionine synthase, vitamin B12 acts by accepting a _____ group from _____ and donating this group to _____ to form methionine.
a. carbon, serine, glycine
b. methyl, 5-methyltetrahydrofolate, homocysteine
c. methyl, formiminoglutamic acid, succinyl-CoA
d. carbon, methionine, folate
methyl, 5-methyltetrahydrofolate, homocysteine
Which is NOT a fate of homocysteine in the cell?
a. used to restore tetrahydrofolate
b. methylated to methionine
c. used in the synthesis of leucine
d. used to synthesize cysteine
used in the synthesis of leucine
Methionine is used to synthesize S-adenosylmethionine (SAM). Why is this important?
a. so that methyl groups are available
b. so that 5-methyl THF is formed
c. so that fatty acids with an odd-numbered chain can be metabolized
d. so that dUMP is catalyzed to dTMP
so that methyl groups are available
Tetrahydrofolate is vitally important for dividing cells during growth and cancer and knowledge of this need is used in cancer treatment by giving the drug methotrexate to inhibit the enzyme _____.
a. dihydrofolate reductase
b. folylpolyglutamate synthetase
c. formimino glutamate
d. conjugase
Tetrahydrofolate is vitally important for dividing cells during growth and cancer and knowledge of this need is used in cancer treatment by giving the drug methotrexate to inhibit the enzyme _____.
a. dihydrofolate reductase
b. folylpolyglutamate synthetase
c. formimino glutamate
d. conjugase
What amount of supplemental folic acid is recommended daily for women of childbearing age in the United States?
a. 400 ug DFE
b. 800 ug DFE
c. 200 ug DFE
d. 600 ug DFE
400 ug DFE
Vitamin B12 is absorbed in the _____.
a. duodenum
b. colon
c. ileum
d. jejunum
ileum
Which of the water-soluble vitamins is able to be stored and retained in the body for long periods of time?
a. folic acid
b. niacin
c. thiamin
d. B12
B12
Large amounts of folic acid can mask a vitamin B12 deficiency and prevent _____ from resulting. Over time the symptoms unique to a vitamin B12
a. DNA and RNA synthesis, vascular system
b. macrocytic anemia, nervous system
c. microcytic anemia, muscular system
d. one-carbon transfer, nervous system
macrocytic anemia, nervous system
Vitamin B6 functions importantly in all of the following EXCEPT _____.
a. synthesis of niacin
b. synthesis of fatty acids
c. transamination of amino acids
d. glycogen breakdown
synthesis of fatty acids
Which of the following dietary substances inhibits uptake of non-heme iron?
a. Lactic Acid
b. Tea
c. MFP
d. Ascorbic Acid
Tea
Absorption of dietary iron is regulated by _____, produced by the liver when iron stores are high and released to the blood to act at the surface of the intestinal crypt cells.
a. Hepaestin
b. Hepcidin
c. Hemoglobin
d. Ferroportin
Hepcidin
Which mineral is critical for oxidizing iron to be bound by transferrin for delivery to the tissues from the gut and liver?
a. Copper
b. Zinc
c. Chromium
d. Manganese
Copper
The binding of iron by proteins defends the cells against
a. Iron deposition in kidneys and other organs
b. Oxidative damage from free radicals
c. Tissue hypoxia
d. Stellate cells
Oxidative damage from free radicals
Which mineral facilitates transfer of electrons in the respiratory chain?
a. Calcium
b. Iron
c. Nickel
d. Zinc
Iron
Hemoglobin and hematocrit are common measurements for assessment of nutriture for which mineral?
a. Iodine
b. Iron
c. Chromium
d. Zinc
Iron
Zinc is important for taste perception as a component of _____.
a. Gustin
b. Alcohol Dehydrogenase
c. Carbonic Anhydrase
d. Thionein
Gustin
Among the trace minerals, which mineral participates in the greatest number of enzyme systems?
a. Zinc
b. Selenium
c. Copper
d. Iron
Zinc
At the cellular level, vitamin A interacts with which mineral in promoting growth and synthesis of plasma protein, especially retinol-binding protein?
a. silicon
b. chromium
c. cobalt
d. zinc
Zinc
Which of the following dietary components impedes copper absorption?
a. phosphate
b. ascorbate
c. citrate
d. gluconate
ascorbate
What two minerals can cause damage to cells when in their free ion forms?
a. iron and copper
b. zinc and copper
c. zinc and molybdenum
d. iodine and manganese
iron and copper
Which vitamin enhances copper transfer and reduction?
a. biotin
b. ß-carotene
c. ascorbic acid
d. niacin
ascorbic acid
What glycoprotein serves as a transporter of copper, an antioxidant, and an oxidative enzyme?
a. globulin
b. ceruploplasmin
c. free amino acid
d. albumin
ceruploplasmin
Which mineral is an essential factor in the action of glutathione peroxidase (GPX) in the reduction of organic peroxides and hydrogen peroxide?
a. selenium
b. molybdenum
c. silicon
d. vanadium
selenium
Which micromineral is necessary for iodine metabolism?
a. selenium
b. chromium
c. manganese
d. fluorine
selenium
Which non-metal nutrient is associated with Keshan disease, characterized by cardiomyopathy?
a. selenium
b. molybdenum
c. iodine
d. zinc
selenium
Which mineral is associated with the glucose tolerance factor (GTF)?
a. cobalt
b. copper
c. manganese
d. chromium
chromium
The primary physiological role of which mineral is as a constituent in the thyroid hormones?
a. chromium
b. fluorine
c. selenium
d. iodine
iodine
The addition to the diet of which food will alleviate the problem of endemic goiter?
a. broccoli
b. cassava
c. cabbage
d. iodized salt
iodized salt
Iodine deficiency associated with growth problems results in _____.
a. goitrin
b. goiter
c. cretinism
d. Keshan disease
cretinism
Which mineral serves as a cofactor in xanthine oxidase in the metabolism of purines, pyrimidines, and pteridines?
a. molybdenum
b. manganese
c. copper
d. chromium
molybdenum
People living in regions that contain high soil molybdenum levels may develop _____.
a. gout
b. cretinism
c. heart disease
d. reduced urea production
gout
Which micromineral plays a contributing role in the formation of hydroxyapatite crystals?
a. arsenic
b. selenium
c. fluoride
d. nickel
fluoride
What is important in antioxidant DEFENSE?
a. all three of these
b. superoxide dismutase (SOD)
c. glutathione
d. iron
e. more than one of these
SOD and glutathione. more than one of these
The following vitamins/ minerals are required for heme synthesis:
a. folate, B12, and iron
b. B6, zinc, and iron
c. copper, zinc, and folate
d. vitamin E, vitamin C, and iron
B6, zinc, and iron.
Hemochromatosis is a genetic disorder that ultimately results in the excessive accumulation of iron in certain tissues.
a. True
b. False
True
Albumin carries zinc and copper in the portal circulation to all tissues in the body.
a. True
b. False
False
Metallothionein is a storage protein for excess zinc and copper.
a. True
b. False
True
All of the following are considered major electrolytes EXCEPT _____.
a. potassium
b. calcium
c. chloride
d. sodium
calcium
Which of the following is considered a major mineral in the body?
a. iron
b. selenium
c. sodium
d. iodine
sodium
Which of the following minerals plays a major role in regulating body fluid pH?
a. sulphur
b. calcium
c. magnesium
d. phosphorus
phosphorus
Deficiency of which major mineral is usually associated with muscular weakness, mental apathy, cardiac arrhythmias,paralysis, bone fragility and adrenal hypertrophy?
a. Sulphur
b. Potassium
c. Calcium
d. Chloride
Potassium
Which mineral provides the most abundant cation in the human body?
a. calcium
b. phosphorus
c. potassium
d. magnesium
calcium
Calcitriol can stimulate the absorption of calcium from the intestines by regulating _____.
a. calmodulin
b. calsequestrin
c. calbindin
d. calcitonin
calbindin
What substance can improve calcium absorption?
a. magnesium
b. phytic acid
c. unabsorbed fatty acids
d. lactose
lactose
lactose
osteoblasts
During which period of the life cycle does peak bone mass occur?
a. 50 years and above
b. 0-10 years
c. 10-25 years
d. 30-40 years
30-40 years
The binding protein that regulates many of the calcium-dependent enzymes is:
a. calcitonin
b. calmodulin
c. globulin
d. albumin
calmodulin
According to the NIH panel on osteoporosis, what calcium levels are recommended for postmenopausal females not treated with estrogen?
a. 1200 mg/d
b. 1500 mg/d
c. 1000 mg/d
d. 800 mg/d
1500 mg/d
In the renal system, which mineral regulates body fluid pH by reacting with secreted hydrogen ions, releasing sodium ions in the process? a. calcium b. phosphorus c. magnesium d. sulphur
phosphorus
Which two minerals are part of the crystal, hydroxyapatite, formed in ossification of bone? A. sulphur, magnesium b. calcium, potassium c. sodium, chloride d. calcium, phosphorus
calcium, phosphorus
Which mineral is LEAST likely to be deficient in anyone’s diet?
a. calcium
b. iodine
c. chromium
d. phosphorus
phosphorus
Which mineral is part of the green chlorophyll pigment in green leafy vegetables?
a. potassium
b. magnesium
c. sulfur
d. sodium
magnesium
Which mineral participates in all aspects of energy metabolism including glycolysis, beta-oxidation and the TCA cycle?
a. calcium
b. sulphur
c. iron
d. magnesium
magnesium
Which mineral has as its primary function to bind phosphate groups in ATP and ATP-dependent enzyme reactions?
a. magnesium
b. sodium
c. calcium
d. potassium
magnesium
Which of the following statements is true?
a. In blood coagulation, the roles of calcium and magnesium are antagonistic, with calcium promoting the process and magnesium being the inhibitor
b. Calcium may cause an alteration in magnesium distribution by changing the flux of magnesium across the cell membrane or displacing it on its binding sites
c. Calcium and magnesium promote each other’s reabsorption in the kidney
d. In muscle contraction, the roles of calcium and magnesium are antagonistic, with magnesium promoting the process and calcium being the inhibitor
In blood coagulation, the roles of calcium and magnesium are antagonistic, with calcium promoting the process and magnesium being the inhibitor.
A food may be labeled “low sodium” if each serving provides:
a. 35 mg or less
b. 140 mg or less
c. less than 5 mg
d. 240 mg or less
140 mg or less
Significant loss of what mineral occurs when one exercises vigorously while the temperature is high?
a. sulphur
b. phosphorus
c. sodium
d. potassium
sodium
Which mineral serves as the major intracellular fluid cation?
a. chloride
b. calcium
c. potassium
d. sodium
potassium
What is a major function of chloride?
a. wound healing
b. maintenance of gastric acidity
c. protein synthesis in cells
maintenance of gastric acidity
Which mineral is the most abundant anion found in extracellular fluid?
a. magnesium
b. chloride
c. phosphorus
d. sodium
chloride
Dietary intake of which mineral correlates positively with blood pressure?
a. potassium
b. magnesium
c. calcium
d. sodium
sodium
Research has shown that supplements of which mineral are associated with significant reductions in both systolic and diastolic blood pressure, especially in individuals with hypertension?
a. potassium
b. sodium
c. calcium
d. magnesium
potassium
Which of the following foods is associated with reduced blood pressure?
a. nuts
b. alcohol
c. red meat
d. sugar
nuts
What ultratrace element plays a role in the metabolism of methionine to taurine?
a. boron
b. arsenic
c. vanadium
d. nickel
arsenic
The element that appears to be needed for formation and utilization of methyl groups and formation of Sadenosylmethionineis _____.
a. vanadium
b. silicon
c. boron
d. arsenic
arsenic
uman toxicity has been shown as blackfoot disease, a peripheral vascular condition, in individuals drinking water contaminated with _____.
a. vanadium
b. silicon
c. boron
d. arsenic
arsenic
Which of the following groups of foods are richest in boron, providing 1.0 to 4.5 mg/100 g?
a. raisins, legumes, nuts and avocados
b. fish and shellfish
c. milk, butter, cheese
d. pork, beef, poultry
raisins, legumes, nuts and avocados
Which ultratrace element affects the composition, structure and strength of bones as well as cell membrane stability and inflammation?
a. cobalt
b. boron
c. arsenic
d. vanadium
boron
Because of its anti-inflammatory actions, which element may reduce the severity of rheumatoid arthritis?
a. boron
b. cobalt
c. arsenic
d. silicon
boron
In humans, signs of nickel _____ include nausea, vomiting, and shortness of breath.
a. toxicity
b. carcinogenesis
c. subclinical deficiency
d. deficiency
toxicity
Which element is second only to oxygen in abundance on earth?
a. vanadium
b. cobalt
c. silicon
d. nickel
silicon
Which element has a positive influence on collagen synthesis and bone mineralization?
a. vanadium
b. nickel
c. arsenic
d. silicon
silicon
The major detrimental effect of a long-term excess of dietary silicon, usually in the form of antacids, is _____.
a. asthma
b. diabetes
c. kidney stones
d. cancer
kidney stones
Which ultratrace element, in pharmacological quantities, mimics the action of insulin?
a. silicon
b. boron
c. vanadium
d. nickel
vanadium
The richest dietary sources of vanadium are _____.
a. sweeteners
b. fats and oils
c. milk products
d. cereal and grain products
cereal and grain products
Toxicity of which element results in green tongue, diarrhea, and GI cramps?
a. silicon
b. boron
c. vanadium
d. nickel
vanadium
Which ultratrace element is a constituent of vitamin B12?
a. cobalt
b. boron
c. vanadium
d. arsenic
cobalt
Which population group is most at risk for chromium deficiency?
a. Adolescents
b. Pregnant women
c. Young adult
d. Men
e. Elderly
f. Infants
Elderly
Which of the following best describes hemosiderin?
a. Increases relative to primary storage form when iron overload occurs
b. Responsible for iron transport in serum
c. Facilitates oxygen transport in muscle
d. Primary storage form of iron
e. Responsible for iron transport within the intestinal cell
Increases relative to primary storage form when iron overload occurs
Which vitamin promotes iron absorption?
a. Folic acid
b. Vitamin B12
c. Vitamin A
d. Vitamin C
e. Vitamin E
Vitamin C
Deficiency of which of the following has been specifically linked to both myocardial infarction and cardiac arrhythmias?
a. Calcium
b. Phosphorus
c. Iron
d. Magnesium
e. Zinc
Magnesium
Hypokalemia may occur as the result of which of the following?
a. bone marrow failure
b. severe tissue destruction
c. prolonged diarrhea
d. prolonged immobilization
e. high sodium intake
prolonged diarrhea
Which of the following minerals is essential to the function of glutathione peroxidase?
a. Copper
b. Zinc
c. Iron
d. Manganese
e. Selenium
Selenium
Superoxide dismutase (SOD), found in the cytoplasm, is dependent upon which two micro minerals?
a. Copper, Manganese
b. Copper, Iron
c. Copper, Zinc
d. Copper, Molybdenum
e. Copper, Selenium
Copper, Zinc
Which of the following is found in bran and legumes and will, in large amounts, have a detrimental effect upon absorption of minerals such as calcium and zinc?
a. Vitamin C
b. Phytate
c. Oxalate
d. Cellulose
e. Aluminum
Phytate
Superoxide dismutase found in the mitochondria is dependent upon which micro mineral?
a. Copper
b. Zinc
c. Iron
d. Molybdenum
e. Manganese
Manganese
Two enzymes that function in the disposal of hydrogen peroxide within cells and tissues are:
a. Glutathione peroxidase and superoxide dismutase
b. Amine oxidase and glutathione peroxidase
c. Catalase and amine oxidase
d. Catalase and superoxide dismutase
e. Glutathione Peroxidase and catalase
Glutathione Peroxidase and catalase
Which of the following minerals is second only to calcium in abundance in the human body?
a. Phosphorous
b. Iron
c. Magnesium
d. Sodium
e. Potassium
Phosphorous
Studies have shown that the following are linked to hypertension. Choose the most inclusive answer.
a. Sodium, chloride, potassium, calcium
b. Sodium, chloride, potassium, calcium, magnesium, sucrose, alcohol consumption
c. Sodium, chloride, potassium, calcium, magnesium, sucrose
d. Sodium, chloride, potassium
e. Sodium, chloride, potassium, calcium, magnesium
Sodium, chloride, potassium, calcium, magnesium, sucrose, alcohol consumption
_____ is secreted in response to low plasma calcium concentrations and acts on the kidney to increase synthesis of _____, which promotes renal reabsorption of calcium.
a. Calcitriol, calmodulin
b. Parathyroid hormone, calcitriol
c. Parathyroid hormone, calcitonin
d. Calcitonin, calcitriol
Parathyroid hormone, calcitriol
One health claim for calcium states that levels above _____ are unlikely to provide additional benefit.
a. 1200 mg/d
b. 800 mg/d
c. 1000 mg/d
d. 2000 mg/d
2000 mg/d
Deficiency of which major mineral is usually associated with muscular weakness, neuromuscular hyper excitability, and tetany?
a. Chloride
b. Magnesium
c. Calcium
d. Sulphur
Magnesium
*Trick question; key word is “deficiency”- Tetany can be the result of an electrolyte imbalance. Most often, it’s a dramatically low calcium level, known as hypocalcemia. But, it can also be caused by magnesium deficiency or too little potassium..
By what mechanism is vitamin C thought to protect bone health?
a. contributing to the integrity of bone collagen
b. carboxylation of osteocalcin and matrix Gla protein
c. buffering for acid-base balance
d. diminishing bone resorption
contributing to the integrity of bone collagen
By what mechanism is vitamin K thought to protect bone health?
a. buffering for acid-base balance
b. carboxylation of osteocalcin and matrix Gla protein
c. contributing to the integrity of bone collagen
d. diminishing bone resorption
carboxylation of osteocalcin and matrix Gla protein
Water accounts for what percentage of the body weight in normal adult?
a. 40%
b. 20%
c. 60%
d. 80%
60%
What percentage of blood volume is circulated through the kidney’s
a. 50%
b. 75%
c. 25%
d. 100%
25%
Which of the components comprising the nephron includes the capillary network called the glomerulus?
a. collecting duct
b. loop of Henle
c. Bowman’s capsule
d. distal convoluted tubule
Bowman’s capsule
Which are responsible for regulation of extracellular water osmolarity and volume?
a. liver and pancreas
b. pancreas and kidney
c. hypothalamus and kidney
d. spleen and bone marrow
hypothalamus and kidney
What percentage of the glomerular filtrate volume is excreted as urine each day?
a. 50%
b. 1%
c. 25%
d. 100%
1%
Which hormone, mediated by the enzyme renin, is primarily responsible for active reabsorption of sodium ions in the distal and collecting tubules?
a. antidiuretic hormone
b. androsterone
c. aldosterone
d. adrenocortical
aldosterone
Which hormone, stimulated by increased blood pressure stretching the heart, functions to inhibit sodium reabsorption to promote sodium excretion?
a. angiotensin II
b. atrial natriuretic peptide
c. aldosterone
d. vasopressin
atrial natriuretic peptide
In which part of the nephron is most of the filtered sodium reabsorbed?
a. distal convoluted tubule
b. proximal tubule
c. collecting ducts
d. ascending loop of Henle
ascending loop of Henle
ncidence of hypertension in populations is considered predictable by _____.
a. serum sodium concentration
b. sodium filtration rate by the kidney
c. urinary sodium excretion
d. average daily sodium intake
average daily sodium intake
Magnesium absorption may be improved by all of the following except?
a. selected carbohydrates
b. protein
c. phosphorous
d. vitamin D
phosphorous
Which mineral is contained in a preformed metallovitamin essential for humans that cannot be synthesized from dietary sources?
a. cobalt
b. boron
c. silicon
d. nickel
cobalt
What ultratrace element has been shown to inhibit Na+/K+-ATPase function and the absorption of amino acids at higher concentrations?
a. vanadium
b. arsenic
c. boron
d. cobalt
vanadium
Dietary _____ inhibits absorption of silicon
a. alkalinity
b. lactose
c. iron
d. fiber
fiber
Which of the microminerals is considered essential for normal brain function?
a. chromium
b. manganese
c. vanadium
d. fluorine
manganese
Iron content of the average Western diet is estimated to be about:
a. 18 g /day
b. 5 to 7 mg iron per 1,000 kcal
c. 1 to 4 mg iron per 1,000 kcal
d. 8 to 15 mg/day
5 to 7 mg iron per 1,000 kcal.
Which mineral facilitates transfer of electrons in the electron transport chain?
a. iron
b. nickel
c. zinc
d. calcium
iron
Excessive intake of non-heme iron interferes with absorption of which mineral by an unknown mechanism?
a. manganese
b. chromium
c. selenium
d. zinc
zinc
The protein that plays a dual function in both iron and copper homeostasis is:
a. transferrin
b. ferritin
c. ceruloplasmin
d. metallothionein
ceruloplasmin
What genetic disorder causes copper toxicity?
a. Wilson’s disease
b. hemochromatosis
c. Menkes disease
d. Keshan disease
Wilson’s disease
