4.1 Chest neoplasm Pathology

Question 1

List the 4 benign chest wall tumors.

Answer 1

Osteochondroma, Chondroma, Fibrous dysplasia, Lipoma

Question 2

List the 5 malignant chest wall tumors.

Answer 2

Chondrosarcoma, Osteosarcoma, Ewing’s Sarcoma, Liposarcoma, Leiomyosarcoma (COELL)

Question 3

What are the lobules of hyaline cartilage encased by bone covered by?

Answer 3

Perichondrium

Question 4

What is the most common mutation in fibrous dysplasia?

Answer 4

Mutation of GNAS1

Question 5

What are the most common soft tissue tumors in adulthood?

Answer 5

Lipoma

Question 6

Where can osteosarcoma spread to?

Answer 6

Spread within the medullary cavity and can invade soft tissue

Question 7

Well differentiated liposarcomas show amplification of what chromosomal segment?

Answer 7

12q13-q15

Question 8

On immunohistochemistry, what findings relate to the tumor originating from the Lung, Breast, and Pleura.

Answer 8

Lungs

• TTF1, Ber Ep4 (adenoca), CK5/6, p63 (in squamous cell carcinoma)

Breast

• ER (estrogen receptor), PR (progresterone receptor), GCDFP15, Mammaglobin

Pleura

• CK 5/6, D2-40, calretinin, WT1 (in mesothelioma)