1.7 Drugs of LRTI

Question 1

What is azithromycin used for and what is a major side effect of it?

Answer 1

Used to treat pertussis, can alter the QT interval in the heart

Question 2

What is the second line treatment for pertussis and what else is it used to treat?

Answer 2

Trimethoprim-sulfamethoxasole, also used to treat Pneumocystic jirovecii

Question 3

Which microlide should not be used for neonates and why?

Answer 3

Erythromycin - linked to infantile hypertrophic pyloric stenosis

Question 4

What is the MOA of doxycycline?

Answer 4

Bind to the 30S ribosome and prevent tRNA from binding at the A site

Question 5

What two microlides have the best oral bioavailability?

Answer 5

Azithromycin and Clarithromycin (AC)

Question 6

What drug class is used in the treatment of CAP with comorbidities, or recent use of antibiotics?

Answer 6

Fluoroquinolones (-floxacin drugs)

Question 7

What is the difference between Hospital acquired pneumonia and ventilator-associated pneumonia?

Answer 7

• Hospital acquired develops 48 hrs or more after admission

- Ventilator acquired occurs 48-72hrs after endotracheal tube intubation

Question 8

What three drugs do you consider if MRSA is suspected?

Answer 8

Vancomycin, Televancin, and Linezolid