1.10 Viral Pathogen, Flu, Vacc. + Antivirals

Question 1

Define Antigenic drift

Answer 1

small changes in H and N driven by point mutations made by the polymerase during replication

Question 2

Define Antigenic shift

Answer 2

LARGE changes in H and N driven by reassortment of genomes among different strains; risk for pandemics

Question 3

State whether A, B, C can go through Antigenic shift/drift

Answer 3

A- both shift and drift

B and C- only drift

Question 4

When do peak sx of influenza present?

Answer 4

between 3-5 days of illness

Question 5

What does a CXR of pnuemonia caused by Influenza A show?

Answer 5

bilateral, midlung or lower lung infiltrate

Question 6

To whom are the inactivated flu shots indicated for?

Answer 6

pts 6mo of younger; pts with chronic conditions

Question 7

How old does a patient have to be to get flumist?

Answer 7

between 2-49 years old

Question 8

What is the cytopathic effect associated with SARS?

Answer 8

structural changes caused in host due to viral invasion

Question 9

Is SARS or non-SARS more resistant to environmental and GI conditions?

Answer 9

SARS

Question 10

What are the vectors of MERS?

Answer 10

Bats and Camels

Question 11

What causes the inflammation in Acute bronchitis?

Answer 11

host immune response

Question 12

What disease presents with nasal flaring, air trapping, and variable fever?

Answer 12

Bronchiolitis