2.2 TB and Tx Flashcards
1
Q
What is miliary TB?
A
Dissemination via lymphatics and bloodstream
2
Q
What type of bacteria is TB?
A
Gram + but doesn’t gram stain. Acid fast bacterium- stained using Ziehl-Neelsen
3
Q
What is the most deadly form of extrapulmonary TB?
A
Meningial TB
4
Q
What are the first line agents against TB?
A
Rifampin, Isoniazid, Pyrazinamide, Ethanbutol, Streptomycin
5
Q
When would you use second line agents?
A
resistance, failure of clinical exposure, serious side effect to first line
6
Q
Which of the first line agents have urine excretion?
A
Pyrazinamide, Ethanbutol, and Streptomycin
7
Q
Which first line agent has CYP induction as an adverse effect?
A
Rifampin
8
Q
What is the MOA of streptomycin?
A
aminoglycside that binds to 30S ribosomal subunit and inhibits protein synthesis
