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Biochemistry > 4 Oxygen Transport > Flashcards

4 Oxygen Transport Flashcards

1
Q

Which immunoglobulin is delivered in Colostrum, and found in the mucous membranes?

A

IgA

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2
Q

Which immunoglobulin is associated with parasitic immunity?

A

IgE

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3
Q

What is the most common Immunoglobulin?

A

IgG

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4
Q

Which immunoglobulin is found on the surface of B-Cells but has a relatively unknown function?

A

IgD

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5
Q

Haptoglobin, Haemopexin and Methemalbumin serve what function?

A

Cleanup of Haemoglobin debris

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6
Q

Where is IgM usually located?

A

in the intravascular space

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7
Q

Which immunoglobulin is a major component of colostrum?

A

IgA

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8
Q

Rare cases of isolated deficiency of which immunoglobulin are found to be associated with no obvious pathology?

A

IgD

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9
Q

Which immunoglobulin is found in the intravascular space and is considered the first immunoglobulin responder?

A

IgM

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10
Q

The morphologic deformity of erythrocytes in Sickle Cell Anaemia is a result of a genetic change in what component of the cell?

A

Haemoglobin proteins

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11
Q

What effect does haemoglobin have on the ability of the blood to carry oxygen?

A

67-fold increase in capacity

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12
Q

Which principle describes the pH effect of oxygen binding and Haemoglobin?

A

the Bohr effect

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13
Q

Why does foetal haemoglobin (HbF) have a different saturation curve to Haemoglobin (Hb)?

A

So the blood of the foetus can extract oxygen from the blood of the mother

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14
Q

IgA appears to function as the primary immunologic barrier in what tissues?

A

Mucous Membranes

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15
Q

Which Immunoglobulin circulates as a pentamer?

A

IgM

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16
Q

Is haemoglobin an absolute requirement for oxygen to be dissolved in the blood?

A

No

17
Q

Which molecule has the higher affinity for oxygen - Myoglobin, or Haemoglobin?

A

Myoglobin

18
Q

What is an important allosteric effector of Hb, which is often found in adaptations to high altitude environments?

A

2,3-Bisphosphoglycerate

19
Q

The two IgA molecules forming dimerized IgA are linked by a molecule called:

A

J Chain

20
Q

Indicators of anaerobic metabolism such as 2,3-Bisphosphoglycerate have what effect on hemoglobin?

A

encourage Hb to give up oxygen

21
Q

Which immunoglobulin plays a major part in allergies and atopy?

A

IgE

22
Q

What protein is a relative of haemoglobin, found only in muscle tissue?

A

Myoglobin

23
Q

The Bohr effect describes an increased pH causing an increase or decrease in the O2 affinity of Hb?

A

Decrease

24
Q

Which immunoglobulin eliminates small, soluble antigenic proteins via enhanced phagocytosis?

A

IgG

25
Q

IgA is found most commonly in what form?

A

Dimerized

26
Q

What is the first antibody to be synthesised after an antigenic challenge?

A

IgM

Biochemistry (13 decks)

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