4 Flashcards
Light microscopy PSGN
Hypercellular glomeruli (leukocytes), mesangial and endothelial proliferation
IF PSGN (starry sky)
Granular deposits of IgG, IgM, and C3*(alternative pathway-no C1 or C4)
EM PSGN
Sub-epithelial humps (Ab-Ag(exotoxinB) deposits)
Subendothelial C1q deposits
Type 1 Membranoproliferative GN
Lupis nephritis: IgE deposits in capillary wall
Poorer prognosis
Cannulation of the femoral vein should occur where?
1cm below inguinal ligament and just medial to the femoral artery pulsation
Variability in mitochondria disease expression is due to
herteroplasmy
Name 3 mitochondria disease
1) LHON-bilateral vision loss
2) Myoclonic epilepsy with ragged-red fibers: myoclonic seizures and myopathy w/ exercise. Red ragged fibers on muscle biopsy
3) MELAS- mitochondrial encephalomyopathy with lactic acidosis and stroke like episodes
Variable expressivity is seen in
AD disorders
M3R in endothelial surface (muscarinic toxicity)
vasodilation/relaxtion (via NO–>hypotension). In other sights causes smooth muscle contraction
M2 receptors (mostly in cardiac muscle)
G-protein decrease intracellular cAMP–>opens potassium channels to slow depolarization. Descreased inotropy (contractility) and chronotropy (HR)
Endocardial cushion defects that result in ostium primum atrial septal defects and regurgitation atrioventricular valves
Down syndorme
aortic valve incompetence, MVP, cystic medial necrosis of aorta
Marfan (AD)
Pericarditis often follows what? Pain is worse when?
Upper respiratory viral syndrome.
Lying flat
Blood pressure disparity btw arms (greater than 10mmHg) and tearing pain to back
aortic dissection
occurs w/ repetitive activity; reproducible pain w/ palpation and worse with movement
costosternal syndrome (costochondritis)
siezures in patient from rural or central south america
neurocysticercosis (Taenia solium - pork tape worm)
Screening test for T.Pallidum
Rapid plasma reagin (RPR) test and VDRL
Confirmatory test for T.Pallidum
FTA-ABS
TTP (FAT-RN)…Differs from DIC because TTP has
NORMAL PT and aPTT
Most common cause of coronary sinus dilation (know your anatomy fool)
elevated right-sided heart pressure secondary to PHTN (pulmonary hypertension)
Low frequency sound commonly associated with increased left ventricular end-systolic volume (left ventricular systolic failure)
S3
When is S3 best heard
Place bell over apex (midclavicular 5th intercostal space) with patient lateral decubitus position
When do you hear an S3
Heart failure, dilated cardiomyopathy, mitral regurg.