34: Toxicology and Substance Abuse Flashcards
Any chemical (drug, poison, or other) that causes adverse effects on an organism.
Toxin
Study of the detection, chemistry, pharmacological actions, and antidotes of toxic substances.
Toxicology
Entry of a substance into the body through the respiratory tract.
Inhalation
Entry of a substance into the body directly through the skin or mucous membrane.
Surface Absorption
Phosphorus-containing organic chemicals.
Organophosphates
Entry of a substance into the body through a break in the skin.
Injection
The process of minimizing toxicity by reducing the amount of toxin absorbed into the body.
Decontamination
Removing an ingested poison by reportedly filling and emptying the stomach with water or saline via a gastric tube; also known as “pumping the stomach”.
Gastric Lavage
A powder, usually premixed with water, that will absorb some poisons and help prevent them from being absorbed by the body.
Activated Charcoal
Administration of polyethylene glycol continuously at 1-2 L/Hr through a nasogastric tube until the effluent is clear or objects are recovered.
Whole bowel irrigation
A substance that will neutralize a specific toxin or counteract its effect on the body.
Antidote
A toxic sydrome; a group of typical signs and symptoms consistently associated with exposure to a particular type of toxin.
Toxidrome
A substance that liberates hydrogen ions when in solution.
Acid
A substance that liberates hydoxyl ions when in solution; a strong base.
Alkali
The maximum tolerated dose divided by the minimum curative dose of a drug; the range between curative and toxic dosages; also called therapeutic window.
Therapeutic Index
A soluble poisonous substance secreted during growth of a bacterium.
Exotoxin
An exotoxin that produces gastrointestinal symptoms adn diseases such as food poisoning.
enterotoxin
Poisoning from a pharmacological substance in excess of that usually prescribed of that the body can tolerate.
Drug overdose
Use of a pharmacological substance for purposes other than medically defined reasons.
Substance abuse
Compulsive and overwhelming dependence on a drug, physiological dependence, a psychological dependence, or both.
Addiction
The need to progressively increase the dose of a drug to reproduce the defect originally achieved by smaller doses.
Tolerance
Referring to alcohol or drugs. In which the patient’s body reacts severely when deprived of the abused substance.
Withdrawal
Disorder found in habitual and excessive users of alcoholic beverages after cessation of drinking for 48-72 Hrs. Patients experience visual, tactile, and auditory disturbances, Death may result in severe cases.
Delirium Tremens (DTs)