34: Toxicology and Substance Abuse Flashcards
Any chemical (drug, poison, or other) that causes adverse effects on an organism.
Toxin
Study of the detection, chemistry, pharmacological actions, and antidotes of toxic substances.
Toxicology
Entry of a substance into the body through the respiratory tract.
Inhalation
Entry of a substance into the body directly through the skin or mucous membrane.
Surface Absorption
Phosphorus-containing organic chemicals.
Organophosphates
Entry of a substance into the body through a break in the skin.
Injection
The process of minimizing toxicity by reducing the amount of toxin absorbed into the body.
Decontamination
Removing an ingested poison by reportedly filling and emptying the stomach with water or saline via a gastric tube; also known as “pumping the stomach”.
Gastric Lavage
A powder, usually premixed with water, that will absorb some poisons and help prevent them from being absorbed by the body.
Activated Charcoal
Administration of polyethylene glycol continuously at 1-2 L/Hr through a nasogastric tube until the effluent is clear or objects are recovered.
Whole bowel irrigation
A substance that will neutralize a specific toxin or counteract its effect on the body.
Antidote
A toxic sydrome; a group of typical signs and symptoms consistently associated with exposure to a particular type of toxin.
Toxidrome
A substance that liberates hydrogen ions when in solution.
Acid
A substance that liberates hydoxyl ions when in solution; a strong base.
Alkali
The maximum tolerated dose divided by the minimum curative dose of a drug; the range between curative and toxic dosages; also called therapeutic window.
Therapeutic Index