31. IMPORTANCE OF MEDICAL RESEARCH Flashcards

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1
Q
  1. Is Medicine inherently experimental?
A
  • yes
  • according to the WMA Medical Ethics Manual
  • these experiments have to be carried out in order to
    see which treatments and mechanisms work
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2
Q
  1. What do Medical experiments focus on?
A
  • they look at the functioning of the human body
  • they look at the causes of diseases
  • they look at ways to prevent or cure diseases
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3
Q
  1. What is the role of the Physician when it comes to Medical Research?
A
  • they care for the patient
  • they look after the health and well-being of the patient
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4
Q
  1. What is the Researcher’s role in Medical Research?
A
  • they are responsible for generating knowledge
  • they may not always be able to promote the health of
    the patient
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5
Q
  1. What clinical areas does Medical Research focus on?
A
  1. Disease Knowledge
  2. Patterns of Diseases
  3. Treatments
  4. Vaccines
  5. Drug Development
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6
Q
  1. What lifestyle areas does Medical Research focus on?
A
  1. BIO-PSYCHO SOCIAL ASPECTS
    - these are the life experiences of the patient
  2. LEGAL AND ETHICAL ASPECTS
    - these are the interactions that happen between the
    doctor and the patient
    - it focuses on the care and disease regimes
  3. HEALTH SYSTEMS
    - these look at the structural factors of any health
    system
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7
Q
  1. What are the aims of Medical Research?
A
  1. Increase the length of a patient’s life
  2. Increase the quality of a patient’s life
  3. Alleviate suffering and pain of the patient
  4. Address the patient’s perspective
  5. Improve the experiences of care
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8
Q
  1. What is a large humanitarian issue when it comes to Medical Research?
A
  • it has used and abused people in the past
  • it has a dark history of experimentation
  • certain research was considered unethical
  • this is because it cruelly experimented on the
    participants
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9
Q
  1. What can be said about Medical Research in the 19th and 20th Century?
A
  • there were experiments that were done on patient’s
    without their consent
  • research was done that clearly violated fundamental
    human rights
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10
Q
  1. What lead to the necessary definition of Ethical Guidelines for Medical Research?
A
  • the public outrage
  • this was aimed at the human right violations that
    occurred during research experiments
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11
Q
  1. What are two very prominent examples of gross human rights violations that occurred in the name of Medical Research?
A
  1. Mengele’s Experiments during WWII
  2. Tuskegee Syphillis Study
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12
Q
  1. What happened with Mengele’s Experiments during WWII?
A
  • Mengele was a Nazi doctor
  • he believed thoroughly in the Aryan ideology and racial
    purity
  • he was known as the Angel of Death
  • he used innocent Jewish citizens in his cruel and
    unethical experiments
  • Mengele’s research was focused in genetics and
    eugenics
  • Mengele particularly tended to use identical Jewish
    twins that were imprisoned in Auschwitz
  • he believed that they allowed him the opportunity to
    experiment on one and compare them to the other
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13
Q
  1. What was the Nuremberg Code?
A
  • this was legislation that was released and implemented
    in 1947
  • it was written after the medical atrocities committed by
    Mengele during WWII to ensure that nothing like this
    would happen again
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14
Q
  1. What are the 10 principles outlined in the Nuremberg Code?
A
  1. THE VOLUNTARY CONSENT
    - of the human subject is absolutely essential
  2. THE EXPERIMENTS SHOULD BE SUCH
    - as to yield fruitful results for the good of society
  3. THE ANTICIPATED RESULTS WILL JUSTIFY
    - the performance of the experiment
  4. THE EXPERIMENT SHOULD BE CONDUCTED
    • to avoid all unnecessary physical and mental
      suffering
    • and injury
  5. NO EXPERIMENT SHOULD BE CONDUCTED
    - where there is a prior reason to believe that death or
    disability will occur for the participants
  6. THE DEGREE OF RISK TO BE TAKEN
    - should never exceed the humanitarian importance of
    the problem to be solved
  7. PROPER PREPARATIONS
    - should be made
    - adequate facilities should be provided to protect the
    experimental participant
  8. THE EXPERIMENT SHOULD BE CONDUCTED
    - only by scientifically qualified personnel
  9. DURING THE COURSE OF THE EXPERIMENT
    - the human subject have the liberty to bring the
    experiment to an end
  10. THE SCIENTIST IN CHARGE
    - must be prepared to terminate the experiment at any
    stage
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15
Q
  1. What happened during the Tuskegee Syphilis Study?
A
  • 600 participants were recruited from African-American
    origin
  • the doctors has run tests on these individuals and
    come to the conclusion that they were suffering with
    Syphilis
  • the participants were not informed of their condition
  • they were given no help or treatment by the doctors
  • the doctors simply watched the disease progress
  • to conduct research on the nature of Syphilis
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16
Q
  1. What is the Belmont Report?
A
  • this is a report written up in the USA
  • it was written after the Tuskegee Syphilis Study
  • this happened between 1932-1972
  • this report outlines the Ethical Principles and
    Guidelines
  • for the Protection of Human Subjects of Research
17
Q
  1. What are the Principles of the Belmont Report?
A
  1. Respect of persons
  2. Beneficence
  3. Justice
    (there can be no bias and discrimination)
18
Q
  1. How are the principles of the Belmont Report applied to the Conduct of Research?
A
  1. INFORMED CONSENT HAS TO BE GIVEN
    - the patient has to comprehend the information
    - there has to be a voluntariness from the patient
  2. RISK AND BENEFIT ASSESSMENT
    • the research has to be justified on a favourable risk
      and benefit assessment
  3. THE SELECTION OF SUBJECTS OF RESEARCH
    • there have to be fair procedures
    • there have to be fair outcomes
19
Q
  1. What is the WMA Declaration of Helsinki?
A
  • this was a declaration that was written and
    implemented in 1964
  • it outlines the Ethical Principles for Medical Research
    that involves Human Subjects
20
Q
  1. What are the areas included in the WMA Declaration of Helsinki?
A
  1. Ethical review of the Medical Research Study
  2. Scientific Grounding
  3. Social Values and Contributions
  4. Assessment of Risks and Benefits
  5. Informed Consent
  6. Confidentiality