3: SIGNALS Flashcards

1
Q

electrical charge across a cell membrane (diff in charge inside + outside cell)

A

MEMBRANE POTENTIAL

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2
Q

2 TYPES OF MEMBRANE POTENTIALS THAT AXONS HAVE

A
  1. RESTING MEMBRANE POTENTIAL
  2. ACTION POTENTIAL
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3
Q

membrane potential of a neuron when it is AT REST (not being altered by excitatory/inhibitory postynaptic potentials)

A

RESTING MEMBRANE POTENTIAL

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4
Q

brief electrical impulse that provides basis for conduction of info along axon

A

ACTION POTENTIAL

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5
Q

2 WAYS MEMBRANE POTENTIAL CAN CHANGE

A
  1. HYPERPOLARIZATION
  2. DEPOLARIZATION
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6
Q

incr in membrane potential of cell relative to normal resting potential (inside axon become more NEGATIVE than outside)

A

HYPERPOLARIZATION

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7
Q

reduction (toward 0) of membrane potential of a cell from its normal resting potential (inside of axon becomes more POSITIVE than outside)

A

DEPOLARIZATION

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8
Q

value of the membrane potential that must be reached to produce an ACTION POTENTIAL

A

THRESHOLD OF EXCITATION

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9
Q

VALUE OF RESTING POTENTIAL

A

-70 mV

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10
Q

VALUE OF THRESHOLD OF EXCITATION

A

-55 mV

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11
Q

VALUE OF ACTION POTENTIAL

A

+40 mV

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12
Q

VALUE OF HYPERPOLARIZED NEURON

A

-90 mV

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13
Q

movement of molecules from regions of HIGH concentration to regions of LOW conentration

A

DIFFUSION GRADIENT

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14
Q

substances that split into 2 particles w opposing electrical charge when dissolved in water

A

ELECTROLYTES

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15
Q

notion that oppositely charged atoms attract + alike atoms repel = due to ____

A

ELECTROSTATIC PRESSURE

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16
Q

notion that CATIONS (+) + ANIONS (-) move towards areas of unlike charge (away from highly +/- areas)

A

ELECTROSTATIC GRADIENT

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17
Q

notion that gradients can balance one another + this is maintained by SODIUM-POTASSIUM PUMP

A

DYNAMIC EQUILIBRIUM

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18
Q

pump that pushes SODIUM ions out of axon in exchange for POTASSIUM ions

A

SODIUM-POTASSIUM PUMP

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19
Q

fluid within cell

A

INTRACELLULAR FLUID

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20
Q

fluid outside cell

A

EXTRACELLULAR FLUID

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21
Q

charge INSIDE cell = more ____

A

NEGATIVE (MORE ANIONS)

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22
Q

charge OUTSIDE cell = more ____

A

POSITIVE (MORE CATIONS)

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23
Q

IONS INSIDE CELL:
LOW concentration of ___ + ___
HIGH concentration of ___ + ___

A

LOW: Cl- + Na+
HIGH: K+ + A-

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24
Q

IONS OUTSIDE CELL:
LOW concentration of ___ + ___
HIGH concentration of ___ + ___

A

LOW: K+
HIGH: Cl- + Na+

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25
Cl- uses ____ to get INSIDE cell + ____ to get OUTSIDE cell
DIFFUSION; ELECTROSTATIC PRESSURE
26
Na+ uses ____ + ____ to get INSIDE cell + ____ to get OUTSIDE CELL
DIFFUSION; ELECTROSTATIC PRESSURE; SODIUM-POTASSIUM PUMP
27
K+ uses ____ to get INSIDE cell + ____ to get OUTSIDE cell
ELECTROSTATIC PRESSURE; DIFFUSION
28
1. THRESHOLD OF EXCITATION PASSED/DEPOLARIZATION: Na+ channels OPEN + Na+ enters cell 2. REPOLARIZATION: K+ channels OPEN + K+ leaves cell 3. PEAK: Na+ channels become REFRACTORY (no more Na+ enters cell) 4. HYPERPOLARIZATION: K+ continues to leave cell + membrane pot returns to RESTING level 5. RESTING: K+ channels CLOSE + Na+ channels RESET 6. extra K+ outside diffuses away
ION MVMTS DURING ACTION POTENTIAL
29
where is an action potential generated?
at AXON HILLOCK
30
ion channel that opens/closes acc to the value of the MEMBRANE POTENTIAL
VOLTAGE-DEPENDENT ION CHANNEL
31
sodium channel blocker that pufferfish contain that PREVENTS ACTION POTENTIALS
TETRODOXIN
32
principle that once an AP = triggered in an axon it CANT be stopped (impulse travels till end of axon)
ALL-OR-NONE LAW
33
principle that variations in INTENSITY of a stimulus/other info being transmitted in an axon = represented by variations in RATE at which axon fires
RATE LAW
34
HIGH rate of AP firing = ___ muscular contraction + STRONG stimulus (bright light) causes ___ rate of firing in axons of eyes
STRONG; HIGH
35
LOW rate of firing = ___ muscular contraction + WEAK stimulus (dim light) causes ___ rate of firing in axons of eyes
WEAK; LOW
36
conduction of AP by myelinated axons where AP jumps from 1 NODE OF RANVIER to the next
SALTATORY CONDUCTION
37
2 ADVANTAGES OF SALTATORY CONDUCTION
1. CONSERVATION OF ENERGY 2. SPEED OF CONDUCTION
38
autoimmune demyelinating disease in which immune system attacks myelin sheaths leaving behind sclerotic plaques + normal transmission of electrical impulses = affected
MULTIPLE SCLEROSIS (MS)
39
macrophages gone wild bc of immune system glitch
PHAGOCYTOSIS
40
programmed cell death
APOPTOSIS
41
junctions btwn TERM BUTTS at end of one axon + membrane of another axon
SYNAPSE
42
membrane of term butt adjacent to POSTSYNAPTIC MEMBRANE thru which neurotransmitter = RELEASED
PRESYNAPTIC MEMBRANE
43
cell membrane OPPOSITE term butt in synapse that RECEIVES msg
POSTSYNAPTIC MEMBRANE
44
smol rounded structures in term butts that contain NTs
SYNAPTIC VESICLES
45
proteins that fill vesicles w NTs
TRANSPORT PROTEINS
46
proteins involved in release of NTs + recycling of vesicles
TRAFFICKING PROTEINS
47
region of interior PRESYNAPTIC MEMBRANE of synapse to which SYNAPTIC VESICLES = attach + release NT into SYNAPTIC CLEFT
RELEASE ZONE
48
secretion of substance of cell thru VESICLES/process by which NTs = released
EXOCYTOSIS
49
chem substance released from end of a neuron during propagation of a nerve impulse that relays info from one neuron to another
NEUROTRANSMITTERS
50
secreted substance composed of peptides that acts like NT except secreted in LARGER amts + diffuses FURTHER in body (not restricted to SYNAPTIC CLEFT)
NEUROMODULATORS
51
chem substance produced in ENDOCRINE GLANDS + released into EXTRACELLULAR FLUID to be taken up by specific targets
HORMONES
52
chemical that attaches to a NT binding site
LIGAND
53
2 EXAMPLES OF LIGANDS
1. NTs 2. NEUROTOXINS
54
3 TYPES OF SYNAPSES (BINDING SITES)
1. AXODENDRITIC 2. AXOSOMATIC 3. AXOAXONIC
55
AXODENDRITIC SYNAPSE
synapse on DENDRITE
56
AXOSOMATIC SYNAPSE
synapse on SOMA
57
AXOAXONIC SYNAPSE
synapse on AXON
58
receptor molecules in POSTSYNAPTIC MEMBRANE of a synapse that contains BINDING SITE for NT
POSTSYNAPTIC RECEPTORS
59
ion channel that opens when a molecule of a NT binds w POSTSYNAPTIC RECEPTOR
NT-DEPENDENT ION CHANNELS
60
2 MAIN TYPES OF POSTSYNAPTIC RECEPTOR/ION CHANNELS
1. IONOTROPIC RECEPTORS 2. METABOTROPIC RECEPTORS
61
DIRECT METHOD: receptor that contains a binding site for a NT + an ion channel that opens when a molecule of the NT attaches to the binding site (contains sodium channels)
IONOTROPIC RECEPTORS
62
INDIRECT METHOD: receptor that contains a binding site for NT + are located nearby G-PROTEINS which activate an ion channel when an NT attaches to the binding site
METABOTROPIC RECEPTORS
63
protein coupled to a METABOTROPIC RECEPTOR that conveys msgs to other molecules when a LIGAND binds w + activates the receptor
G-PROTEIN
64
DEPOLARIZATION/HYPERPOLARIZATION caused by activation of POSTSYNAPTIC RECEPTORS w molecules of NT
POSTSYNAPTIC POTENTIAL
65
meaning electrical charge = MORE POSITIVE than resting potential (MORE likely to fire)
EXCITATORY
66
meaning electrical charge = MORE NEGATIVE than resting potential (LESS likely to fire)
INHIBITORY
67
what are POSTSYNAPTIC POTENTIALS determined by?
ION CHANNEL OPENED BY NT (NOT NT ITSELF)
68
4 MAJOR TYPES OF NT-DEPENDENT ION CHANNELS IN POSTSYNAPTIC MEMBRANE
1. Na+ 2. K+ 3. Cl- 4. Ca2+
69
ACTION POTENTIALS are always ____
EXCITATORY (AP)
70
EXCITATORY DEPOLARIZATION of the POSTSYNAPTIC MEMBRANE of a synapse caused by the liberation of a NT by the term butt
EXCITATORY POSTSYNAPTIC POTENTIAL (EPSP)
71
Which ION CHANNEL opens during an EPSP?
SODIUM CHANNELS
72
INHIBITORY HYPERPOLARIZATION of the POSTSYNAPTIC MEMBRANE caused by the liberation of a NT by the term butt
INHIBITORY POSTSYNAPTIC POTENTIAL (IPSP)
73
Which ION CHANNEL opens during an IPSP?
POTASSIUM CHANNELS
74
2 MECHANISMS THAT TERMINATE PSP
1. REUPTAKE 2. ENZYMATIC DEACTIVATION OF NTs
75
rapid removal of NT from synaptic cleft that terminates PSP
REUPTAKE
76
drugs that prolong PSP by INHIBITING REUPTAKE
SSRIs (SELECTIVE SEROTONIN REUPTAKE INHIBITORS)
77
destruction of NT by an enzyme after its release that terminates PSP
ENZYMATIC DEACTIVATION OF NTs
78
process by which INHIBITORY + EXCITATORY PSPs summate + control rate of firing a neuron
NEURAL INTEGRATION
79
EXCITATORY synapse activity INCR = AP firing rate ___
INCR
80
INHIBITORY synapse activity INCR = AP firing rate ___
DECR
81
type of NEURAL INTEGRATION in which equal EXCITATORY/INHIBITORY input will cause NO CHANGE
SPATIAL INTEGRATION
82
type of NEURAL INTEGRATION in which ripples can combine to make bigger ripples
TEMPORAL INTEGRATION
83
receptors in PRESYNAPTIC MEMBRANE that respond to NTs they produce by regulating synthesis + release of other NTs
AUTORECEPTORS
84
When NT binds to AUTORECEPTOR = ___ rate of synthesis/release of NT from PRESYNAPTIC CELL
DECR rate
85
disease of dopamine deficiency
PARKINSON'S DISEASE
86
disease involving abnormal electrical stimulation
EPILEPSY
87
disease when neurofibrillary tangles affect transport of NTs
ALZHEIMER'S