13: MOTOR CONTROL + DISORDERS Flashcards
3 BASAL GANGLIA DISORDERS
- PARKINSON’S DISEASE
- HUNTINGTON’S DISEASE
- TOURETTE’S SYNDROME
motor deficit disorder that involve deficiency of AUTOMATIC/HABITUAL resps caused by damage to BASAL GANGLIA
PARKINSON’S DISEASE
degeneration of NIGROSTRIATAL SYSTEM
specific cause of PARKINSON’S DISEASE
system of DOPAMINE-secreting neurons of SUBSTANTIA NIGRA that send axons to BASAL GANGLIA
NIGROSTRIATAL SYSTEM
- HYPOKINESIA/BRADYKINESIA/AKINESIA
- PARKINSONIAN MASK
- RESTING TREMORS
- COGWHEEL RIGIDITY
- postural/gait disturbances
SYMPTOMS OF PARKINSON’S DISEASE
difficulty INITIATING mvmt
HYPOKINESIA
SLOWNESS in control of mvmt
BRADYKINESIA
SLOWNESS of THOUGHT
BRADYPHRENIA
ABSENCE of mvmt
AKINESIA
frozen facial fts
PARKINSONIAN MASK
vibratory mvmts of arms/hands that diminish somewhat when individuals makes PURPOSEFUL mvmts
RESTING TREMOR
stereotypical mvmts made at rest that resembles rolling a pill btwn fingertips/thumb
PILL-ROLLING TREMOR
small rigid steps in a passive mvmts caused by INCR muscle tone in EXTENSOR/FLEXOR muscles that leads to RESISTANCE to mvmt
COGWHEEL RIGIDITY
- L-DOPA
- ANTI-CHOLINERGIC DRUGS
- STALEVO
DRUG TREATMENTS FOR PARKINSONS DISEASE
INCR ___ in brain causes patients remaining DOPAMINE neurons to produce/secrete MORE DOPAMINE which alleviates symptoms of disease for a bit
L-DOPA
this type of drug REDUCES uptake of ACETYLCHOLINE + restores balance btwn DOPAMINE/ACETYLCHOLINE that was damaged by depletion of DOPAMINE
ANTI-CHOLINERGIC DRUGS
new combination medication that INCR DOPAMINE levels in brain
STALEVO
surgical stereotaxic lesioning of INTERNAL DIVISION OF GLOBUS PALLIDUS to treat PD (GPi = stimulated first to determine region responsible for excessive inhibition)
PALLIDOTOMIES
division of GLOBUS PALLIDUS that provides INHIBITORY input to MOTOR CORTEX via THALAMUS
INTERNAL DIVISION OF GLOBUS PALLIDUS
lesion of ___ ___ used for patients w ADVANCED PD
SUBTHALAMIC NUCLEUS