2.4.1 Bordetella spp Flashcards

1
Q

Virulence factor that facilitate attachment to ciliated epithelial cells

A

Filamentous Hemagglutinin and Pertactin

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2
Q

Virulence factor that interferes to signal transduction and induces chemokines and Cytokines

A

Pertussis toxin

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3
Q

Inhibits early neutrophil recruitment?

A

Pertussis toxin

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4
Q

Inhibits host epithelial and immune effector cells

A

Adenylate cyclase toxin

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5
Q

Causes Ciliostasis and inhibiting DNA synthesis

A

Tracheal cytotoxin

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6
Q

Pertussis is also known as?

A

Whooping cough

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7
Q

What is the incubation for pertussis

A

7-10 days

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8
Q

what are the 3 phases of Pertussis?

A

Catarrhal phase
Paroxysmal phase
Convalescent phase

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9
Q

Phase that is highly communicable, which consist of sneezing, runny nose, mild cough

A

Catarrhal phase

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10
Q

Phase that hase sudden onset of severe repetitive coughing : Whoop

A

Paroxysmal phase

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11
Q

Phase the diminished paroxysmal cough, development of secondary complication such as pneumonia, seizures

A

Convalescent phase

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12
Q

How many weeks does Catarrhal phase last?

A

1-2 weeks

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13
Q

How many weeks does Paroxysmal phase last?

A

2-4 weeks

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14
Q

How many weeks does Convalescent phase last?

A

3-4 weeks

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15
Q

What is the MOT?

A

Droplets or direct contact

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16
Q

Where does it replicate?

A

Ciliated respiratory epithelial cells