2.4.1 Bordetella spp Flashcards
Virulence factor that facilitate attachment to ciliated epithelial cells
Filamentous Hemagglutinin and Pertactin
Virulence factor that interferes to signal transduction and induces chemokines and Cytokines
Pertussis toxin
Inhibits early neutrophil recruitment?
Pertussis toxin
Inhibits host epithelial and immune effector cells
Adenylate cyclase toxin
Causes Ciliostasis and inhibiting DNA synthesis
Tracheal cytotoxin
Pertussis is also known as?
Whooping cough
What is the incubation for pertussis
7-10 days
what are the 3 phases of Pertussis?
Catarrhal phase
Paroxysmal phase
Convalescent phase
Phase that is highly communicable, which consist of sneezing, runny nose, mild cough
Catarrhal phase
Phase that hase sudden onset of severe repetitive coughing : Whoop
Paroxysmal phase
Phase the diminished paroxysmal cough, development of secondary complication such as pneumonia, seizures
Convalescent phase
How many weeks does Catarrhal phase last?
1-2 weeks
How many weeks does Paroxysmal phase last?
2-4 weeks
How many weeks does Convalescent phase last?
3-4 weeks
What is the MOT?
Droplets or direct contact