1.1.2 Haemophilus Influenzae Flashcards
Common name for H. influenzae?
Pfeiffer’s bacillus
Virulence factors of Haemophilus influenzae?
Capsule
IgA protease
Outer membrane proteins and LPS
Adherence mechanisms
Components of capsule?
Ribose
Ribitol
Phosphate (Polyribitol phosphate)
Virulence factor that has the function of Antiphagocytic and Anticomplementary
Capsule
How many serotypes o H influenzae?
6 (a-f)
What serotype is the most common and potent and leading cause of meningitis in children?
Serotype b (Hib)
Paralyzing effect on the sweeping motion of ciliated respiratory epithelium
Outer membrane protein and Lipopolysaccharide
What strains that lacks adherent capability usually cause meningitis?
Encapsulated or typable strains
What strains that associated with localized infections or may be carried asymptomatically and cause hepatitis media
Non encapsulated or non typable strains
In encapsulated strains, meningitis is mostly attack at the ages?
3 months to 6 years old
MOT of meningitis for encapsulated strains?
Inhalation (Respiratory tract)
Acute inflammation and swelling of epiglottis?
Epiglottits
Epiglottits usually affects what age?
2-4 years old
Treatment for epiglottits?
Tracheostomy
Serious life threatening disease in young children?
Bacterial tracheitis
Characteristic of sputum in Bacterial tracheitis?
Purulent sputum
Other signs and symptoms of Bacterial tracheitis?
High fever and pseudomembrane
BARKY cough
What is the treatment for bacterial tracheitis?
Broad spectrum antibiotic
IV fluids
What are the disease for encapsulated strains or invasive diseases?
Meningitis
Epiglottitis
Bacterial tracheitis
Arthritis
Speticemia
Pneumonia
What are the localized infections for non encapsulated strains?
Conjunctivitis
Sinusitis
Otitis media
Localized disease for bronchitis and pneumonia can be seen in what patient?
Older patients
