2.4 Flashcards

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1
Q

3 basic parts of neurons

A

Dendrites
Cell body
Axons

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2
Q

Dendrites

A

Nerve fibres that can receive nervous signals from another neuron or sense organ. They then pass these signals to the cell body

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3
Q

Cell body

A

Cell body contains cytoplasm, nucleus, mitochondria and ribosomes for the neuron. The DNA is important as it contains genes for production neurotransmitters

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4
Q

Axon

A

Long cell structure that can carry nervous signals at speed. The ends of the axon terminate at the synapse between 2 neurons. Axon surrounded by myelin sheath

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5
Q

What is axon surrounded by

A

Myelin sheath

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6
Q

Myelin sheath purpose

A

Insulates axon and allows speed of impulses to be increased , allowing cells to transmit signals more quickly. This is why children have slower reaction speeds

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7
Q

When is myelin sheath formed

A

Myelin sheath formed during early development (conception) (myelination)

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8
Q

Problems with myelin sheath if damaged

A

People lose coordination and speed in their movement. Neurones experience problems with correct transmission of signals

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9
Q

Disease of myelin example

A

Multiple Sclerosis (MS)

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10
Q

Synapse

A

The gap between two neurones.

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11
Q

How do electrical signals cross synapses

A

First neuron releases chemicals called neurotransmitters to cross the gap and activate a signal in the second neurone.

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12
Q

Synaptic cleft

A

Tiny region between the axon ending of one neurone and the dendrite of another neurone.

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13
Q

Presynaptic neuron

A

Neuron carrying signal before the synapse

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14
Q

Postsynaptic neuron

A

Neuron that generates signal after synapse

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15
Q

Neurotransmitter

A

Protein that crosses the synapse and binds to receptor on postsynaptic membrane

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16
Q

Vesicles

A

Small membrane bound organelles which act as containers for neurotransmitters.

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17
Q

What do vesicles do when electrical signal arrives

A

Rise to the surface of presynaptic membrane and fuse with the membrane to allow the release of neurotransmitters into synaptic cleft

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18
Q

Two ways you can dispose of neurotransmitters are

A

Reuptake by presynaptic membrane
Enzyme degradation (breakdown)

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19
Q

How does reuptake work

A

Presynaptic membrane contains receptors that can collect and re absorb the neurotransmitter back into the Presynaptic knob.

The neurotransmitter can then be repackaged into vesicles or broken down

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20
Q

Example of neurotransmitter reuptake

A

Adrenaline

21
Q

How does breakdown / enzyme degradation work

A

Certain enzymes act to break down specific neurotransmitters in the synaptic cleft, preventing them from further transmission

22
Q

Neurotransmitter enzyme degradation example

A

Acetylcholine

23
Q

Excitatory receptors

A

When a neurotransmitter binds to an excitatory receptor, the change of an impulse being created is increased

24
Q

Inhibitory receptors

A

If a neurotransmitter binds to an inhibitory receptor on the postsynaptic membrane, it decreases the chances of an impulse being created

25
Q

Threshold

A

In order for impulse transmission to be successful, there must be enough neurotransmitters bound to receptors on the postsynaptic membrane. This helps prevent constant stimulation of nervous pathways.

26
Q

Summation

A

If enough weak stimuli release enough neurotransmitters across a synapse, this can be enough to generate a signal in the postsynaptic neuron. (Several weak signals combining to reach threshold)

27
Q

Endorphins

A

Neurotransmitter released by brain. Stimulate neurones to reduce pain. Painkilling properties have been linked to improve mood and reduce depression.

28
Q

How to increase endorphins

A

Pain, intense exercise, stress, eating chocolate

29
Q

Dopamine

A

Neurotransmitter induces feelings of pressure and happiness . Involved in reward pathway

30
Q

Reward pathway

A

When body engages in beneficial behaviour, brain releases dopamine. Dopamine activates neurons which emit positive feelings, making them more likely to do it again.

31
Q

Behaviours that activate reward pathway

A

Eating when hungry
Drinking when thirsty
Having sex
Positive social interactions

32
Q

Types of neurotransmitter treatments

A

Agonists
Antagonists
Drugs that inhibit reuptake
Drugs that inhibit breakdown enzymes

33
Q

Agonists

A

Mimic the shape of a neurotransmitter. They can bind to receptors on the postsynaptic membrane and cause a similar action to the main neurotransmitter. They cause activation of those receptors in a similar way to the original neurotransmitter.

34
Q

Example of agonists used

A

Parkinsons treated by giving dopamine agonists.

35
Q

Antagonists

A

Antagonists bind to a receptor, but cause no action, blocking any neurotransmitters from stimulating the receptor. The normal action of the neurotransmitter, wether excitatory or inhibitory, is blocked.

36
Q

Antagonists example

A

Beta blockers, block noradrenaline

37
Q

Reuptake inhibitors

A

Allow the effects of some neurotransmitters to last longer as they prevent their reabsorptiom into the Presynaptic knob.

38
Q

Reuptake inhibitors example

A

Depression by seratonin Reuptake inhibitors (SSRIS)

39
Q

Neurotransmitter breakdown enzymes inhibitor

A

Prevent breakdown of neurotransmitters in the synaptic cleft, allowing for longer duration and more signalling of neurotransmitters.

40
Q

Recreational drugs can affect

A

Mood , cognition, perception, behaviour, movement, digestion, reproduction

41
Q

Addiction

A

Needing drug to feel normal

42
Q

Tolerance

A

Requiring more of the drug to feel an effect

43
Q

How is addiction caused

A

Addiction caused by repeated use of antagonists. Blockage of receptors causes the postsynaptic neuron to make more receptors and they become more sensitive. sensitisation !!

44
Q

How is tolerance caused

A

Tolerance caused by repeated use of agonists. Repeated activation of receptors causes Presynaptic neuron to lower their number. This means larger amount of drug needed for same effect. Desensitisation

45
Q

Tolerance example

A

Alcohol

46
Q

Addiction example

A

Ketamine

47
Q

Sensitisation

A

Number of receptors increase

48
Q

Desentisisation

A

Number of receptors decrease