22 - Science of Rheumatoid Arthritis Flashcards
name 4 changes to a joint which has been affected by RA?
inflamed synovium, inflamed tendon sheath, thinning of joint cartilage and erosion of bone
name 4 functions of the synovium?
maintenance of tissue surface, lubrication of cartilage, control synovial fluid volume, nutrition of chondrocytes
what 2 substances make up the synovial fluid?
hyaluronan, lubricin
define RA?
chronic symmetric polyarticular inflammatory joint disease
which joints are usually affected by RA?
small joints of the hands and feet
how is rheumatoid synovitis characterised? (3)
inflammatory cell infiltration, synoviocyte proliferation and neoangiogenesis
describe the synovial fluid during RA flare?
contains neutrophils
what does synovial pannus cause?
bone and cartilage destruction
name 2 antibodies commonly associated with seropositive RA?
rheumatoid factors and anti-citrullinated protein antibodies (ACPA)
name 1 way in which autoantibodies can contribute to inflammation in RA?
activation of complement
how is seropositive RA diagnosed?
anti-CCP assays - these recognise ACPAs
name 4 of the ACPAs which may be present in seropositive RA?
alpha-enolase, keratin, fibrinogen, collagen etc.
which autoantibodies are associated with seronegative RA?
NONE
is there a genetic link with RA?
Yes - esp twins
which locus is associated with a risk of developing RA?
HLA-DRB1 locus