15 - Paget's disease of bone

Question 1

what is Paget’s disease of bone?

Answer 1

Increased bone resorption followed by increased bone formation

Question 2

what is the effect of Paget’s on the bone?

Answer 2

Leads to disorganised bone: bigger, less compact, more vascular and more susceptible to deformity and fracture

Question 3

what loci is involved in genetic component of Paget’s?

Answer 3

Loci of SQSTMI

Question 4

who is most affected by Paget’s?

Answer 4

anglo-saxon origin individuals

Question 5

what is a possible environmental factor of paget’s?

Answer 5

chronic viral infection within osteoclast

Question 6

describe typical presentation of patient with Paget’s?

Answer 6

presents in a patient>40 years with bone pain occasionally presents with bone deformity/fracture, excessive heat over the Pagetic bone, hearing loss

Question 7

more sinister association of Paget’s?

Answer 7

osteosarcoma in affected bone

Question 8

which test result is hallmark for Paget’s?

Answer 8

isolated elevation of serum alkaline phosphatase

Question 9

treatment for Paget’s?

Answer 9

IV biphosphonate therapy - one off zoledronic acid infusion

Question 10

how do you treat asymptomatic Paget’s?

Answer 10

can be ignored (unless in skull - surgical intervention)