2.12 - Mutataions and CF

Question 1

What is frameshift?

Answer 1

The impact depends where in the gene the mutation occurs.

Question 2

How does substituition affect amino acids?

Answer 2

Only changes one or a few

Question 3

How does deletion affect amino acids?

Answer 3

Frameshift (Affects all amino acids from that point)

Question 4

How does insertion affect amino acids?

Answer 4

Frameshift (Affects all amino acids from that point)

Question 5

How does duplication affect amino acids?

Answer 5

Frameshift if not a multiple of 3: affects all amino acids from that point
Less impact if it’s a multiple of 3

Question 6

How does inverion affect amino acids?

Answer 6

only changes amino acids in section involved

Question 7

What is the name of the gene affected in cystic fibrosis?

Answer 7

CFTR gene

Question 8

What is the definition of a mutation?

Answer 8

Change in sequence of DNA bases

Question 9

Where does a frameshift affect the most?

Answer 9

Near the start of the gene