2015 pharma

Question 1

Which of the following indicates the safety margin of a drug?
A) efficacy
B) therapeutic index

Answer 1

B) therapeutic index

Question 2

What is the maintenance dose if the bioavailability = 1, dosing rate= 40mg/h, and it is administered every 12 hours?
A) 240
B) 420
C) 480
D) 820

Answer 2

C) 480

Question 3

When are chelating agents helpful?
A) Treatment of alcohol poisoning
B) Treatment of heavy metal poisoning

Answer 3

B) Treatment of heavy metal poisoning

Question 4

How do taxanes inhibit the cell during mitosis?
A) By inhibiting depolymerization of tubulin
B) By inhibiting the blood supply of the cell
C) By preventing the polymerization of tubulin
D) By inhibiting DNA of the cell

Answer 4

A) By inhibiting depolymerization of tubulin

Question 5

How does Vinca alkaloid act on neoplastic cells?
A) By inhibiting depolymerization of tubulin
B) By preventing the polymerization of tubulin
C) By inhibiting DNA of the cell

Answer 5

B) By preventing the polymerization of tubulin

Question 6

What is the best description of volume distribution (Vd)?

Answer 6

The volume that would be necessary to contain the total amount of an administered drug at the same concentration that it is observed in the blood plasma

Question 7

Which of the following a-antagonists is prescribed for the treatment of hypertension?
A) Ephedrine
B) Tyramine
C) Prazosin

Answer 7

C) Prazosin

Question 8

Which of the following is used for the treatment of sea sickness?
A) Tyramine
B) Scopolamine

Answer 8

B) Scopolamine

Question 9

A patient undergoing surgery was given suxamethonium to relax his muscle. How could this be potentiated?
A) Administration of gentamicin
B) Administration of neostigmine

Answer 9

A) Administration of gentamicin

Question 10

What is the method of elimination of gentamicin?

Answer 10

Renal clearance

Question 11

How can organophosphate poisoning be treated?

Answer 11

Atropine

Question 12

What treats overdose of salicylates?

Answer 12

Sodium bicarbonate

it alkalizes the urine so acids are excreted

Question 13

What type of adverse drug reaction is penicillin?
A) Type A reaction
B) Type B, allergic reaction

Answer 13

B) Type B, allergic reaction

Question 14

If the Vd of a drug is 40L and its CL is 13 ml/l, what is the loading dose required to achieve a desired plasma concentration of 4mg/L?

Answer 14

160 mg

Question 15

What is contraindicated if a patient is on a prescription of monoamine oxidase (MAO) inhibitors?

Answer 15

Tyramine

Question 16

Which of the following does cocaine inhibit?

Answer 16

Uptake 1

Question 17

What is the mechanism of action of hemicholinium?

Answer 17

Block choline reuptake

Question 18

Which adrenergic receptor causes lipolysis when activated?

Answer 18

B3

Question 19

What could a diet rich in grapefruit juice cause?

Answer 19

Inhibition of CYP450

Question 20

What is true about drug excretion?

Answer 20

Most of the drugs follow first order linear kinetic

Question 21

Which drug produce its effect without binding to a receptor or a macromolecular substance?

Answer 21

Antacids

Question 22

A patient suffers from a polymorphism in one of the CYP450 enzymes, which makes him a poor metabolizer of the associated drugs. What effect would be present if drugs metabolized by this enzyme were administered?

Answer 22

Increased toxicity