2015 pharma Flashcards
Which of the following indicates the safety margin of a drug?
A) efficacy
B) therapeutic index
B) therapeutic index
What is the maintenance dose if the bioavailability = 1, dosing rate= 40mg/h, and it is administered every 12 hours? A) 240 B) 420 C) 480 D) 820
C) 480
When are chelating agents helpful?
A) Treatment of alcohol poisoning
B) Treatment of heavy metal poisoning
B) Treatment of heavy metal poisoning
How do taxanes inhibit the cell during mitosis?
A) By inhibiting depolymerization of tubulin
B) By inhibiting the blood supply of the cell
C) By preventing the polymerization of tubulin
D) By inhibiting DNA of the cell
A) By inhibiting depolymerization of tubulin
How does Vinca alkaloid act on neoplastic cells?
A) By inhibiting depolymerization of tubulin
B) By preventing the polymerization of tubulin
C) By inhibiting DNA of the cell
B) By preventing the polymerization of tubulin
What is the best description of volume distribution (Vd)?
The volume that would be necessary to contain the total amount of an administered drug at the same concentration that it is observed in the blood plasma
Which of the following a-antagonists is prescribed for the treatment of hypertension?
A) Ephedrine
B) Tyramine
C) Prazosin
C) Prazosin
Which of the following is used for the treatment of sea sickness?
A) Tyramine
B) Scopolamine
B) Scopolamine
A patient undergoing surgery was given suxamethonium to relax his muscle. How could this be potentiated?
A) Administration of gentamicin
B) Administration of neostigmine
A) Administration of gentamicin
What is the method of elimination of gentamicin?
Renal clearance
How can organophosphate poisoning be treated?
Atropine
What treats overdose of salicylates?
Sodium bicarbonate
it alkalizes the urine so acids are excreted
What type of adverse drug reaction is penicillin?
A) Type A reaction
B) Type B, allergic reaction
B) Type B, allergic reaction
If the Vd of a drug is 40L and its CL is 13 ml/l, what is the loading dose required to achieve a desired plasma concentration of 4mg/L?
160 mg
What is contraindicated if a patient is on a prescription of monoamine oxidase (MAO) inhibitors?
Tyramine
Which of the following does cocaine inhibit?
Uptake 1
What is the mechanism of action of hemicholinium?
Block choline reuptake
Which adrenergic receptor causes lipolysis when activated?
B3
What could a diet rich in grapefruit juice cause?
Inhibition of CYP450
What is true about drug excretion?
Most of the drugs follow first order linear kinetic
Which drug produce its effect without binding to a receptor or a macromolecular substance?
Antacids
A patient suffers from a polymorphism in one of the CYP450 enzymes, which makes him a poor metabolizer of the associated drugs. What effect would be present if drugs metabolized by this enzyme were administered?
Increased toxicity
