2012 pharma

Question 1

Which adrenergic receptor that when activated causes lipolysis?
A. β3
B. β2
C. β1

Answer 1

A. β3

Question 2

Which adrenergic receptor agonist has the therapeutic use of decogestion?!
A. β3
B. α1

Answer 2

B. α1

Question 3

Which cholinergic drug is used to treat motion sickness?! A. Scopolamine
B. Ipratropium
C. Atrophine

Answer 3

A. Scopolamine

Question 4

What is the effective action of muscarinic agonist?
A. Bronchoconstriction
B. Bronchodialation

Answer 4

A. Bronchoconstriction

Question 5

What is the Phase-II Reaction?

Answer 5

Sulfation

Question 6

A polymorphism in which of the following causes a pharmacodynamic effect?
A. In a gene that is responsible for eye color
B. In a gene that is responsible for drug targets

Answer 6

B. In a gene that is responsible for drug targets

Question 7

What is a potential disadvantage of pharmacogenetics?
A. Increased number of drugs
B. reduced cost
C. personalized medicine

Answer 7

A. Increased number of drugs

Question 8

What is the mechanism of action of hemicholinium?
A. induce choline release
B. Block choline reuptake
C. Block of Ach storage

Answer 8

B. Block choline reuptake

Question 9

Which of the following is used to treat asthma?	
A. benztropine
B. Atropine
C. Pirenzepine
D. Ipratropium

Answer 9

D. Ipratropium

Question 10

What is true about drug excretion?
A. Most drugs follow first order linear kinetics
B. Most drugs follow zero order kinetics

Answer 10

A. Most drugs follow first order linear kinetics

Question 11

Which factor should you consider before you prescribing a highly metabolized drug?
A. Renal function
B. Hepatic function

Answer 11

B. Hepatic function

Question 12

A diet with a large intake of grapefruit juice will cause?
A. Activate CYP450
B. Inhibit CYP450
C. Inhibit CYP2D6

Answer 12

B. Inhibit CYP450

Question 13

What is a characteristic of bizarre adverse reactions?
A. They are rare and lethal
B. They are common and recoverable

Answer 13

A. They are rare and lethal

Question 14

What is an adverse effect of anticholinesterases?
A. rapid increase in body temperature
B. Respiratory depression

Answer 14

B. Respiratory depression

Question 15

Which neurotransmitter mediates the transmission in both post and presynaptic neurons of parasympathetic and sympathetic neurons?!
A. Nonadrenaline
B. Acetylcholine
C. Adrenaline

Answer 15

B. Acetylcholine

Question 16

What can be used to treat scopolamine overdose?
A. Physostigmine
B. Bethanechol
C. Gentamycin

Answer 16

A. Physostigmine

or any other anticholinesterase

Question 17

What is an adverse effect of suxamethonium?
A. Hypokalemia
B. Hyperkalemia
C. hypernatremia

Answer 17

B. Hyperkalemia

Question 18

Which drug blocks uptake 1?
A. Dicyclic antidepressants
B. Cocaine
C. Tyramine

Answer 18

B. Cocaine

Question 19

Which drug displaces NA from the vesicle and into the synapse?
A. Cocaine
B. Ephedrine
C. Amphetamine
D. MAO inhibitors

Answer 19

C. Amphetamine

Question 20

What measures the relationship between the percentage of people who respond to a drug versus the dose of the drug?

Answer 20

Quantal response curves

Question 21

What is the main cause of kernicterus in neonates?

a. low bilirubin levels
b. high albumin levels
c. Lack of glucuronidation reactions

Answer 21

c. Lack of glucuronidation reactions

kernicterus also occurs because if high bilirubin

Question 22

What is the first thing a doctor must do to an intoxicated patient?

Answer 22

Stabilize the patient

Question 23

What is the function of vinca alkaloids?

a. inhibit protein synthesis
b. Inhibit tubulin polymerization
c. inhibit DNA synthesis
d. inhibits blood supply

Answer 23

b. Inhibit tubulin polymerization

Question 24

Drug A has a higher Kd than drug B. What is true?

a. Drug B has a higher potency than Drug A
b. Drug B has a higher affinity than Drug A
c. Drug B has a lower potency than Drug A
d. Drug B has a lower affinity than Drug A

Answer 24

b. Drug B has a higher affinity than Drug A

Kd = dissociation constant; its the inverse of affinity

Question 25

a question about calculating maintenance/loading dose

Answer 25

Loading Dose= Vd x Plasma concentration

Maintenance Dose= Clearance x Plasma concentration