2012 pharma Flashcards
Which adrenergic receptor that when activated causes lipolysis?
A. β3
B. β2
C. β1
A. β3
Which adrenergic receptor agonist has the therapeutic use of decogestion?!
A. β3
B. α1
B. α1
Which cholinergic drug is used to treat motion sickness?! A. Scopolamine
B. Ipratropium
C. Atrophine
A. Scopolamine
What is the effective action of muscarinic agonist?
A. Bronchoconstriction
B. Bronchodialation
A. Bronchoconstriction
What is the Phase-II Reaction?
Sulfation
A polymorphism in which of the following causes a pharmacodynamic effect?
A. In a gene that is responsible for eye color
B. In a gene that is responsible for drug targets
B. In a gene that is responsible for drug targets
What is a potential disadvantage of pharmacogenetics?
A. Increased number of drugs
B. reduced cost
C. personalized medicine
A. Increased number of drugs
What is the mechanism of action of hemicholinium?
A. induce choline release
B. Block choline reuptake
C. Block of Ach storage
B. Block choline reuptake
Which of the following is used to treat asthma? A. benztropine B. Atropine C. Pirenzepine D. Ipratropium
D. Ipratropium
What is true about drug excretion?
A. Most drugs follow first order linear kinetics
B. Most drugs follow zero order kinetics
A. Most drugs follow first order linear kinetics
Which factor should you consider before you prescribing a highly metabolized drug?
A. Renal function
B. Hepatic function
B. Hepatic function
A diet with a large intake of grapefruit juice will cause?
A. Activate CYP450
B. Inhibit CYP450
C. Inhibit CYP2D6
B. Inhibit CYP450
What is a characteristic of bizarre adverse reactions?
A. They are rare and lethal
B. They are common and recoverable
A. They are rare and lethal
What is an adverse effect of anticholinesterases?
A. rapid increase in body temperature
B. Respiratory depression
B. Respiratory depression
Which neurotransmitter mediates the transmission in both post and presynaptic neurons of parasympathetic and sympathetic neurons?!
A. Nonadrenaline
B. Acetylcholine
C. Adrenaline
B. Acetylcholine
What can be used to treat scopolamine overdose?
A. Physostigmine
B. Bethanechol
C. Gentamycin
A. Physostigmine
or any other anticholinesterase
What is an adverse effect of suxamethonium?
A. Hypokalemia
B. Hyperkalemia
C. hypernatremia
B. Hyperkalemia
Which drug blocks uptake 1?
A. Dicyclic antidepressants
B. Cocaine
C. Tyramine
B. Cocaine
Which drug displaces NA from the vesicle and into the synapse? A. Cocaine B. Ephedrine C. Amphetamine D. MAO inhibitors
C. Amphetamine
What measures the relationship between the percentage of people who respond to a drug versus the dose of the drug?
Quantal response curves
What is the main cause of kernicterus in neonates?
a. low bilirubin levels
b. high albumin levels
c. Lack of glucuronidation reactions
c. Lack of glucuronidation reactions
kernicterus also occurs because if high bilirubin
What is the first thing a doctor must do to an intoxicated patient?
Stabilize the patient
What is the function of vinca alkaloids?
a. inhibit protein synthesis
b. Inhibit tubulin polymerization
c. inhibit DNA synthesis
d. inhibits blood supply
b. Inhibit tubulin polymerization
Drug A has a higher Kd than drug B. What is true?
a. Drug B has a higher potency than Drug A
b. Drug B has a higher affinity than Drug A
c. Drug B has a lower potency than Drug A
d. Drug B has a lower affinity than Drug A
b. Drug B has a higher affinity than Drug A
Kd = dissociation constant; its the inverse of affinity
a question about calculating maintenance/loading dose
Loading Dose= Vd x Plasma concentration
Maintenance Dose= Clearance x Plasma concentration
