2013 pharma

Question 1

A drug is administered through intravenous infusion has a half-life of 12 hours. How many hours will the drug take to reach 75% steady state plasma concentration?
A. 16

B. 24 
C. 48

D. 76

D. 90

Answer 1

B. 24

Question 2

Which is a phase II type of reaction?

A. oxidation
b
B. deamination
c
C. hydroxylation

D. sulphate
E. hydrolysis

Answer 2

D. sulphate

Question 3

What is the effect of alpha 2 receptor activation?

A. increase cAMP formation
B. decrease cAMP formation

Answer 3

B. decrease cAMP formation

Question 4

Which of these is a selective alpha-1 antagonist used to treat hypertension?
A. Prazosin
B. Atenolol
C. Reserpine

Answer 4

A. Prazosin

Question 5

A patient was going to have a surgery & intubation, he was given a non-depolarizing NMB and was subjected to prolonged muscle paralysis. Which of the following was present in his body that potentiated this symptom?

a) Atropine
b) Gentamycin
c) Negostamine
d) propranolol

Answer 5

b) Gentamycin

Question 6

What can be used to treat scopolamine overdose?
A. Atropine
B. Physostigmine
C. Neostigmine

Answer 6

B. Physostigmine

Question 7

What is the mechanism of action of hemicholinium?
A. Inhibit Ach storage
B. inhibit Ach release
C. Inhibits the uptake of choline

Answer 7

C. Inhibits the uptake of choline

Question 8

Which of the following drugs can be used for the treatment of organophosphate poisoning?
A. Atropine
B. Ipratropium
C. Neostigmine

Answer 8

A. Atropine

Question 9

Which of the following characterizes both sympathetic and parasympathetic nervous systems?
A. Both have NA in the postsynaptic neuron
B. Both have NA in the presynaptic neuron
C. Both have Ach in the presynaptic neuron

Answer 9

C. Both have Ach in the presynaptic neuron

Question 10

Which of these drugs results in hyperthermia & hyperkalemia?
A. Vecuronium
B. Suxamethionium 
C. Tubocurarine
D. Mivacurium

Answer 10

B. Suxamethionium

Question 11

If a genetic codon changed from ATT ACT and the amino acid has changed. What is this called?
A. Non-synonymous polymorphism
B. Synonymous polymorphism

Answer 11

A. Non-synonymous polymorphism

Question 12

Beta-adrenergic antagonist that leads to 
bronchospasms
A. Propanalol
B. Tyramine
C. Salbutamol

Answer 12

A. Propanalol

Question 13

How can you give a drug that has high affinity but no efficacy?

A. Agonist
B. Antagonist
C. Prodrug

Answer 13

B. Antagonist

Question 14

When is carbachol contraindicated?
A. Hypothyroidism
B. Peptic ulcer

Answer 14

B. Peptic ulcer

Question 15

Which of the following anti-cancer drugs block the cancer cell’s blood supply?
A. Antimetabolites
B. Tyrosine kinase inhibitors
C. Anti-hormones drugs
D. Angiogenesis inhibitors
E. Topoisomerase inhibitors

Answer 15

D. Angiogenesis inhibitors

Question 16

Which type of drugs binds to 10% of its available receptors and gives maximal effect?

a. partial agonist 

b. low potency, high efficacy 

c. high potency, low efficacy

d. full agonist

Answer 16

d. full agonist

Question 17

What is Whole bowel irrigation used for?

Answer 17

Sustained release preparations