2-Zoonotic and Transboundary Diseases Flashcards
What is an acute highly infectious viral disease of cattle, pigs, sheep, goats and wild cloven-hoofed animals, characterized by the formation of vesicular eruptions in the mouth and on the feet, esp. around the hooves?
Foot and Mouth Disease
What are 7 examples of USDA prohibited import diseases?
- Foot and Mouth Disease
- Classical Swine Fever
- African Swine Fever
- Swine Vesicular Disease
- Bovine Spongiform Encephalopathy
- Exotic Newcastle Disease (vND)
- Highly Pathogenic Avian Influenza
How many different serotypes of Foot and Mouth Disease are there?
How many “different” viruses?
- 7
- 20-25
What is the reservoir for Foot and Mouth Disease?
What is a specific example?
- Wildlife
- Cape Buffalo
What are 2 types of vaccines available for Foot and Mouth Disease?
- Killed
- Experimental recombinant vaccines
What type of a host are sheep and goats with FMD?
What type of a carrier?
- Maintenance
- Pharyngeal tissue 4-6 months
What type of a host are pigs for FMD?
What type of a carrier?
- Amplifier
- Not a carrier
What type of a host are cattle for FMD?
What type of a carrier?
- Indicator
- Pharyngeal tissue 6-24 months
What are 3 examples of clinical signs of FMD seen in sheep and goats?
- Fever
- Lameness
- Oral lesions
What makes the diagnosis and prevention of spread of FMD in sheep and goats difficult?
Clinical signs are often mild.
What are 3 clinical signs of FMD in pigs?
- Hoof lesions
- Snout vesicles
- Oral vesicles
Are FMD hoof lesions in pigs more or less severe than they are in cattle?
More severe in pigs.
Which FMD clinical sign in pigs is very painful and can be found around the coronary band, heel or interdigital space?
Hoof lesions
What are 6 clinical signs that can be seen with FMD in cattle?
- Oral lesions (vesicles)
- Excess salivation
- Drooling
- Nasal discharge
- Lethargy
- Loss of body condition
Where are 6 possible locations of oral lesions seen in cattle with FMD?
- Tongue
- Dental pad
- Gums
- Soft palate
- Nostrils
- Muzzle
What do teat lesions seen with FMD in cattle lead to?
Decreased milk production.
Where are 2 possible locations of hoof lesions seen with FMD in cattle?
What are 2 other clinical signs that can be seen in relation to the hoof lesions?
- Interdigital space, coronary band
- Lameness, reluctant to move
What virus causes Rinderpest?
Paramyxovirus
Rinderpest is a disease of which species?
Ruminants (esp. cattle)
Which disease is characterized by fever, dysentery and inflammation of the mucous membranes?
Rinderpest
Does Rinderpest have a high mortality?
Yes, very high mortality.
How many strains of Rinderpest are there?
One
Are there any vaccines available for Rinderpest?
Yes, one
Do you see lifetime immunity with Rinderpest?
Yes
How is Rinderpest spread?
Almost exclusively by contact between infected and susceptible animals.
T/F: Rinderpest has been eradicated world-wide.
True
What are 7 clinical signs seen with the classic form of Rinderpest?
- Fever
- Depression
- Anorexia
- Constipation followed by hemorrhagic diarrhea
- Serous to mucopurulent nasal/ocular discharge
- Necrosis and erosion of the oral mucosa
- Enlarged lymph nodes
Death form Rinderpest is seen within how many days?
6-12 days
What is a highly infectious, often fatal disease of swine caused by a flavivirus (genus Pestivirus) and characterized by fever, loss of appetite, weakness, erythematous lesions especially in light-skinned animals and severe leukopenia?
Classical Swine Fever
Low pathogenicity isolates of Classical Swine Fever can be seen where?
Americas
How many strains of Classical Swine Fever are there?
One
Are there vaccines available for Classical Swine Fever?
Yes, one
Do you see lifetime immunity with Classical Swine Fever?
Yes
How is Classical Swine Fever spread?
Almost exclusively by direct contact between infected and susceptible animals.
What are 9 clinical signs seen with the acute form of Classical Swine Fever?
- High fever (105F)
- Huddling, weakness
- Anorexia
- Conjunctivitis
- Diarrhea
- Staggering
- Cyanosis
- Skin hemorrhages
- Death
What is an acute highly contagious usually fatal disease of swine that is caused by a double-stranded DNA virus (genus Asfivirus, family Asfarviridae), that resembles but is more severe than CSF, and that is indigenous to Africa?
African Swine Fever
Which virus causes Classical Swine Fever?
Flavivirus genus Pestivirus
Which virus causes African Swine Fever?
Asfivirus, family Asfarviridae
What is the reservoir for African Swine Fever?
Warthogs, other suidae
How many strains of African Swine Fever are there?
Multiple strains
Is there any cross-protection between the different strains of African Swine Fever?
No cross-protection
Is there a vaccine for African Swine Fever?
No
What are 7 clinical signs seen with acute African Swine Fever?
- High fever
- Moderate anorexia
- Erythema, cyanosis
- Recumbency
- Bloody diarrhea
- Abortion
- Death
What is the incubation period for acute African Swine Fever?
<5 to 19 days
Are there vaccines available for Swine Vesicular Disease?
No
Swine Vesicular Disease is caused by a single-stranded icosahedral RNA virus found in what viral family?
Picornaviridae
The virus that causes Swine Vesicular Disease is antigenically related to which human virus?
Coxsackievirus B5
Is the virus that causes Swine Vesicular Disease related to other known porcine enteroviruses?
No
T/F: The virus that causes Swine Vesicular Disease can only survive for short periods of time in the environment.
False - It can survive for long periods in the environment.
The virus causing Swine Vesicular Disease is resistant to heat up to what temperature?
In what pH range?
- 157F/69C
- pH from 2.5 to 12
How long can the virus that causes Swine Vesicular Disease survive in dried, salted or smoke meat?
Up to 2 years
Is Swine Vesicular Disease contagious?
Yes, highly contagious
Does Swine Vesicular Disease have a low or high mortality rate?
Low - up to 10% in piglets
Can you see persistent infection with Swine Vesicular Disease?
No
Are there protective antibodies present post-infection with Swine Vesicular Disease?
Yes
Does Swine Vesicular Disease have a lower or higher morbidity compared to FMD?
Are the lesions less or more severe?
- Lower
- Less
What are 4 diseases that can cause vesicle formation on the snout of pigs?
- Swine Vesicular Disease
- Foot and Mouth Disease
- Vesicular Stomatitis
- Vesicular Exanthema
What is the incubation period for bovine spongiform encephalopathy?
2 to 8 years
What are 4 initial neurological signs that can be seen with bovine spongiform encephalopathy?
- Apprehension
- Fear
- Easily startled
- Depressed
What are 6 clinical signs that can be seen in the final stages of bovine spongiform encephalopathy?
- Excitable
- Hyperreflexia
- Hypermetria (ataxia where movements overreach intended goal)
- Ataxia
- Muscle fasciculation
- Tremors
What is the most likely form of transmission with BSE?
Ingestion of BSE contaminated feed.
What are 2 clinical signs that can be seen with the terminal state of BSE?
- Decreases rumination
- Loss of body weight and condition despite good appetite
Are there any forms of treatment available for BSE?
No
Are there vaccines available for BSE?
No
What is the morbidity range of BSE?
The mortality rate?
- 2-3%
- 100%
What are 3 forms of virulent Newcastle Disease?
- Mesogenic
- Velogenic neurotropic
- Velogenic viscerotropic
Which type of virulent Newcastle Disease is called Exotic Newcastle Disease in the US?
Velogenic viscerotropic
What are 6 ways vND transmitted?
- Direct contact with feces
- Respiratory secretions
- Feed, water
- Equipment
- Human clothing
- Contaminated or incompletely inactivated vaccines
What is a major clinical sign seen with vND?
Drop in egg production
When are deaths seen with vND?
How long do they continue for?
- 24 to 48 hours
- 7 to 10 days
Birds surviving vND may have what 2 signs?
- Neurological
- Reproductive damage
Is vaccination available for vND?
Yes
What does the vND vaccine reduce?
What does it not prevent?
- Clinical signs
- Does not prevent virus replication or shedding
vND vaccination is not an alternative to what 3 things?
- Good management
- Biosecurity
- Good hygiene
What genus and family is Avian influenza virus in?
- Genus: Influenzavirus A
- Family: Orthomyxoviridae
Avian Influenza is classified into subtypes based on what?
Surface antigens
What are the 2 types of surface antigens seen with Avian Influenza?
How many types are there of each?
- Hemagglutinin: 16 types
- Neuraminidase: 9 types
What does high pathogenicity avian influenza cause?
Which 2 subtypes are involved?
- Severe disease, mortality in poultry
- H5 or H7
What does low pathogenicity avian influenza cause?
Which H subtypes are seen?
- Causes mild disease in poultry.
- 1-16
What can happen with LPAI H5 or H7 subtypes?
Can mutate into HPAI.
Small changes in influenza virus due to point mutations accumulated during virus replication are known as what?
Antigenic drift
Abrupt change in virus subtype caused by genetic reassortment between subtypes, direct transfer of virus or re-emergence of virus is known as what?
Antigenic shift
What are 3 types of birds that can be affected by HPAI?
- Wild birds: waterfowl, shorebirds
- Cage birds: passerines
- Poultry
What are 8 examples of mammals that can be affected by HPAI?
- Pigs
- Horses
- Mink
- Cats
- Dogs
- Ferrets
- Stone martens
- Palm civets
What are 3 requirements for avian influenza to be considered epidemic?
Which strain has not met the third criteria in humans?
- New influenza subtype emerges
- AI must produce disease in that species
- Sustainable transmission must occur within new host species
- Asian lineage H5N1
Are vaccines routinely used in the US for AI?
No
What type of vaccine is used with AI?
Autogenous vaccines
Which disease requires approval of the state veterinarian and USDA for vaccine use?
Avian influenza for H5 and H7
Will AI vaccination prevent virus shedding?
It may not prevent virus shedding.
What strategy is used to recognize field viruses in vaccinated flocks?
Differentiating Infected from Vaccinated Animals (DIVA)
What are 5 examples of USDA prevention activities for avian influenza?
- Import restrictions: no live birds or bird products from infected countries.
- Increasing surveillance of wild birds.
- National H5 and H7 control program.
- Training for disease recognition.
- Improving diagnostics for rapid detection.
The USDA monitors interstate movement for what 8 diseases?
- Bovine Tuberculosis (White tail deer)
- Bovine Brucellosis (Bison)
- Scrapie
- Johne’s Disease
- Chronic Wasting Disease
- Exotic Newcastle Disease
- Viral Hemorrhagic Septicemia
- Pseudorabies
What are 15 diseases that are on the OIE List A of notifiable disease?
- Foot and Mouth
- Swine vesicular Disease
- Peste des petits ruminants
- Lumpy skin disease
- Bluetongue
- African horse sickness
- Classical swine fever
- Newcastle disease
- Vesicular stomatitis
- Rinderpest
- Contagious bovine pleuropneumonia
- Rift Valley fever
- Sheep pox and goat pox
- African swine fever
- Highly pathogenic avian influenza
Approximately what percentage of recently emerging infectious diseases affecting humans are diseases of animal origin?
75%
Approximately what percentage of all human pathogens are zoonotic?
60%
What are 2 ways to control human disease from zoonotic diseases?
- Animal vaccination
- Disease “eradication”