1B: Neurodegenerative

Question 1

hippocampal atrophy

Answer 1

Alzheimer’s Disease

Question 2

loss of neurons in substantia nigra

Answer 2

Parkinson’s Diseas

Question 3

basal ganglia

Answer 3

Huntington’s Disease

Question 4

motor neuron

Answer 4

ALS

Question 5

autosomal dominant, mutation HTT gene,
increased CAG repeats

Answer 5

huntington’s disease

Question 6

alpha synuclein, LRRK2 (dominant), parkin,
DJ-1, PINK1 (recessive)

Answer 6

parkinsons disease

Question 7

amyloid protein precursor gene, chromosome 21,
presenilin1, presenilin2 (dominant, early onset

Answer 7

alzheimer disease

Question 8

C9ORF72 gene (30-40%), SOD1 gene (15-20%)

Answer 8

ALS

Question 9

APOE gene

Answer 9

Alzheimer disease

Question 10

morphology found in substantia nigra region in brains of Parkinsons patient

Answer 10

Lewy Bodies

Question 11

excess of this NT can cause cell death

Answer 11

glutamate

Question 12

neuroprotective drug against ALS

Answer 12

memantine (AD) riluzole

Question 13

repeated head trauma (boxer), tremors, speech problem,
confusion, bradykinesia

Answer 13

Punch-Drunk Syndrome

Question 14

drug of choice for Parkinson

Answer 14

Levodopa

Question 15

drug that is Good for control of on and off phenomenon in PD

Answer 15

Dopamine receptor antagonist

Question 16

increases methylation levodopa by
COMT to 3-O-methyldopa

Answer 16

AADC Inhibitor

Question 17

treatment for Huntington

Answer 17

tetrabenazine

Question 18

treatment for ALS

Answer 18

riluzole, edaravone