1B CONCEPTS: PHARMACODYNAMICS Flashcards
1
Q
effects of drugs , mechanisms of action
A
PHARMACODYNAMICS
2
Q
Effects differ from patient to patient
A
PHARMACOGENETICS
3
Q
Corpora non agunt nisi fixata
A
•A drug will not work unless it is bound (to a receptor)
4
Q
Receptor Occupancy Theory
A
- Assumes that response emanates from a receptor occupied by a drug
- Drugs commonly alter the rate or magnitude of an intrinsic cellular response rather than create new responses
5
Q
•Drug Target or Drug Receptor
A
- Protein molecules whose function is to recognize and respond to endogenous chemical signals = ligands
- Cellular macromolecule with which the drug interacts to elicit cellular response
- Usually located on the surface of cells; may be located in intracellular components such as the nucleus
6
Q
Types OF REGULATORY PROTEINS
A
- Physiological Receptors
- Enzymes
- Carriers or Transporters
- Ion Channels
7
Q
Physiological Receptors
A
- Sensing elements
- For endogenous chemical messengers e.g., hormones, neurotransmitters
- Also used by drugs as target molecules
8
Q
Chemical bonds
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- Covalent bonds – strong; usually irreversible binding
- Ionic bond – weak; between a cation and an anion
- Other weak electrostatic bonds – hydrogen, van der Waals, hydrophobic bonds
9
Q
initiating the same reaction or activity typically produced by the binding of an endogenous substance
A
Agonism
10
Q
•Gateways that selectively allow passage of particular ions, induced either to open or close
A
•Ion Channels
11
Q
A
12
Q
A