1B CONCEPTS: PHARMACODYNAMICS Flashcards

1
Q

effects of drugs , mechanisms of action

A

PHARMACODYNAMICS

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2
Q

Effects differ from patient to patient

A

PHARMACOGENETICS

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3
Q

Corpora non agunt nisi fixata

A

•A drug will not work unless it is bound (to a receptor)

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4
Q

Receptor Occupancy Theory

A
  • Assumes that response emanates from a receptor occupied by a drug
  • Drugs commonly alter the rate or magnitude of an intrinsic cellular response rather than create new responses
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5
Q

•Drug Target or Drug Receptor

A
  • Protein molecules whose function is to recognize and respond to endogenous chemical signals = ligands
  • Cellular macromolecule with which the drug interacts to elicit cellular response
  • Usually located on the surface of cells; may be located in intracellular components such as the nucleus
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6
Q

Types OF REGULATORY PROTEINS

A
  1. Physiological Receptors
  2. Enzymes
  3. Carriers or Transporters
  4. Ion Channels
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7
Q

Physiological Receptors

A
  • Sensing elements
  • For endogenous chemical messengers e.g., hormones, neurotransmitters
  • Also used by drugs as target molecules
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8
Q

Chemical bonds

A
  • Covalent bonds – strong; usually irreversible binding
  • Ionic bond – weak; between a cation and an anion
  • Other weak electrostatic bonds – hydrogen, van der Waals, hydrophobic bonds
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9
Q

initiating the same reaction or activity typically produced by the binding of an endogenous substance

A

Agonism

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10
Q

•Gateways that selectively allow passage of particular ions, induced either to open or close

A

•Ion Channels

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11
Q
A
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12
Q
A
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