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All the things continued > 19.1: Inflammatory dermatoses > Flashcards

19.1: Inflammatory dermatoses Flashcards

1
Q

What is the key cell that comprises the epidermis? How are these organized?

A

Keratinocyte

Layers

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2
Q

What is the stem cell layer of the epidermis?

A

Stratum basale

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3
Q

What are the five layers of the epidermis, from superficial to deep?

A
  • Stratum corneum
  • Stratum lucidum
  • Stratum granulosum
  • Stratum spinosum
  • Stratum basale

(“Come Let’s Get SunBurned”)

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4
Q

What connects the cells in the stratum spinosum?

A

Desmosomes

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5
Q

Where are the blood vessels in the epidermis?

A

There are none–only in the dermis

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6
Q

What are the s/sx of atopic dermatitis?

A

Pruritic, erythematous, oozing rash with vesicles and edema

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7
Q

What parts of the body in particular are affected with atopic dermatitis?

A

Face and flexor surfaces

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8
Q

What type of hypersensitivity reaction is atopic dermatitis? What other disorders are associated with this (2)?

A
  • Type I

- Asthma and allergic rhinitis

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9
Q

What is the common name for atopic dermatitis?

A

Eczema

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10
Q

Pruritic, erythematous, oozing rash with vesicles and edema located over the face and flexor surfaces = ?

A

Atopic dermatitis

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11
Q

Contact dermatitis and atopic dermatitis present similarly. What is the major difference between the two?

A

Contact dermatitis arises upon exposure to allergens, and is NOT associated with asthma / allergic rhinitis

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12
Q

What type of hypersensitivity reaction is contact dermatitis?

A

Type IV

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13
Q

What plant classically causes contact dermatitis? Jewelry type?

A
  • Poison ivy

- Ni jewelry

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14
Q

What is the abx that classically results in contact dermatitis?

A

PCN

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15
Q

What is the treatment for contact dermatitis?

A
  • Removal of offending agent

- Topical steroids

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16
Q

What are comedones?

A

Whiteheads and blackheads seen in acne vulgaris

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17
Q

What, generally, is acne vulgaris? (hint: what two parts are inflamed)

A

Chronic inflammation of the hair follicles and sebaceous glands

18
Q

What is the bacterium that infects in acne vulgaris, and leads to inflammation?

A

Propionibacterium acnes

19
Q

Why is it that acne is seen in adolescents?

A

Increased keratinocytes in the hair shaft and increased sebum production

20
Q

What is the enzyme that Propionibacterium acnes produces that causes inflammation?

A

Lipases

21
Q

What is the role of benzoyl peroxide in the treatment of acne?

A

Antimicrobial to kill Propionibacterium and thus stop the inflammatory process

22
Q

What is the role of vitamin A derivatives (retinoids) in the treatment of acne?

A

Reduces keratin production

23
Q

What, generally, is psoriasis?

A

Well circumscribed, salmon-colored plaques with silvery scale

24
Q

Where on the body does psoriasis usually manifest?

A

Extensor surfaces and scalp

25
Q

What fingernail pathology may be seen with psoriasis?

A

Pitting

26
Q

Well circumscribed, salmon colored plaques with silvery scale on the extensor surfaces and scalp = ?

A

Psoriasis

27
Q

What causes psoriasis?

A

Excessive keratinocyte proliferation, with a possible autoimmune etiology

28
Q

What HLA haplotype is associated with psoriasis?

A

HLA-C

29
Q

What is the supposed environmental trigger for psoriasis?

A

Trauma

30
Q

What is the acanthosis that is seen in psoriasis?

A

Increased thickness of the epidermis from keratinocyte proliferation

31
Q

What is parakeratosis?

A

Excess keratin production, with retained nuclei

32
Q

What is the significance of elongation of the dermal papillae, and the thin epidermis that lies above it in psoriasis?

A

Pinpoint bleeds that occur with removing the thin scale seen with psoriasis

33
Q

What is the name of the collection of PMNs in the stratum corneum?

A

Munro microabscesses

34
Q

What is the sign of the pinpoint bleeding from removal of the scaly plaque seen with psoriasis?

A

Osvet’s sign

35
Q

What is the treatment for psoriasis? (3)

A
  • Corticosteroids
  • UV light with psoralen
  • Immune modulating therapy
36
Q

What is the role of UVA light in the treatment of psoriasis?

A

Prevent the proliferation of keratinocytes

37
Q

What are the four P’s of lichen Planus?

A
  • Pruritic
  • Planar
  • Polygonal
  • Purple plaques
38
Q

What areas of the body are commonly affected with Lichen planus? (3)

A
  • Wrists
  • Elbows
  • Oral mucosa
39
Q

What are the superficial findings of Lichen planus?

A

Reticular white lines on surface

40
Q

What is the histological characteristics of Lichen planus?

A

Inflammation of the dermal-epidermal junction, causing a sawtooth appearance

41
Q

Sawtooth histological appearance at the dermal-epidermal junction = ?

A

Lichen planus

42
Q

What infectious agent is associated with lichen planus?

A

Hep C

All the things continued (28 decks)

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