14.1 Penis Flashcards
What causes hypospadias?
Failure of the urethral folds to close
What causes epispadias? What is it associated with?
Abnormal position of the genital tubercle
Associated with bladder exstrophy
What is bladder exstrophy? What is this associated with?
Opening of the anterior wall of the abdomen to the bladder
EPispadias
What causes condyloma acuminatum in males?
HPV 6 and 11
What is the characteristic histological change associated with condyloma acuminatum?
Koilocytic change–rasinoid appearing nuclei
What is lymphogranuloma venereum?
Necrotizing granulomatous inflammation of the inguinal lymphatic and lymph nodes, caused by chlamydia trachomatis
Why is chlamydia an obligate intracellular organism?
Cannot make ATP on its own
What is the infectious form of chlamydia? What are the form of chlamydia that actually live inside cells?
Elementary bodies are infectious
Reticulate bodies actually live inside cells
What diseases do the serotypes A-C of chlamydia cause?
Trachoma–roughening of the inner surface of the eyelids. This roughening can lead to pain in the eyes, breakdown of the outer surface or cornea of the eyes, and possibly blindness. Untreated, repeated trachoma infections can result in a form of permanent blindness when the eyelids turn inward
What diseases do the serotypes D-K of chlamydia cause?
Urogenital infx and conjunctivitis
What diseases do the serotypes L1-L3 of chlamydia cause?
Lymphogranuloma venereum
What is the final outcome of lymphogranuloma venereum?
Heads with fibrosis or rectal strictures
What are the two major risk factors for the development of SCC of the penis?
High risk HP
Lack of circumcision
What is Bowen’s disease of the penis? Prognosis?
In situ carcinoma that presents are leukoplakia on the shaft of the penis
May progress to malignant CA
What is erythroplasia of Queyrat? Prognosis?
SCC in situ on the glans of the penis, that presents as erythroplasia
May progress to malignant CA
