14: Lipolysis and Fatty Acid Oxidation Flashcards
1
Q
What enzymes are involved in lipolysis?
A
lipases
2
Q
What enzyme attacks the DAG and removes the second FA?
A
hormone sensitive lipase
3
Q
What activates hormone sensitive lipase by phosphorylating it?
A
catecholamines
4
Q
What inactivates hormone sensitive lipase by dephosphorylating it?
A
insulin
5
Q
T/F: Most FAs exist as their CoA forms inside cells
A
T
6
Q
What is the most abundant protein in blood?
A
albumin
7
Q
What transports FAs in blood?
A
albumin
8
Q
What is FA oxidation coupled to?
A
TCA cycle and ETC
9
Q
Steps of beta oxidation
A
- production of acyl CoA
- crossing the mitochondrial outer membrane
- formation of acyl carnitine
- crossing the mitochondrial inner membrane
- production acyl CoA
10
Q
What must happen for TG breakdown to occur?
A
1.catecholamines activate cAMP and PKA
2. PKA activates HSL to start lipolysis
- PKA inactivates acetyl CoA carboxylase to turn off FA synthesis
11
Q
What must happen for FA synthesis to occur?
A
- insulin activates protein phosphatase and cAMP phosphodiesterase
- inactivation of HSL to turn off lipase
- activation of acetyl CoA carboxylase to turn on FA synthesis
- insulin promotes glucose uptake via GLUT4
12
Q
Dephosphorylation does what to HSL?
A
inactivates
13
Q
Phosphorylation does what to HSL?
A
activates
