14 Flashcards
difference btwn antiseptic and disinfectant
antiseptic chemicals applied to living tissuedisinfectant chemicals applied to inanimate objects
types of antiseptics
Alcohol 60-70%IodophorsChlorohexidineTriclosan
Characteristics of alcohol antiseptics
rapid bacterialcidal (not spores, variable viruses)60-70%denatures bacT proteins, interfere with metabolism and lysis of cellsefficacy decreased in presence of organic material
T/FIsopropyl alcohol has better bactericidal activity but less virucidal activity than ethyl alcohol
TRUEIsopropyl alcohol has better bactericidal activity but less virucidal activity than ethyl alcohol
Characteristics of iodophors antiseptics
iodine containingI2 bacteriacidal (NOT I-)disorders protein structure, blocks protein synthesis, alters cell membranesalso kills spores, viruses, fungi(ex. povidone-iodine)
concentration of povidone iodine lethal to canine fibroblasts
lethal to canine fibroblasts at 0.5-1.0%
adverse skin reaction to povidone iodine
50% (HIGHER THAN CHLOROHEXIDINE GLUCONATE)
Difference btwn chlorohexidine gluconate and chlorohexidine acetate
chl gluconate: SCRUB 2-4%chl acetate: SOLUTION < 0.05% (wound treatments)
characteristics of chlorohexidine antiseptics
does NOT kill sporesbacterialcidalvariable at viruses and fungireduced activity in presence of organic debris residual activity/cumulative effect
activity of chlorohexidine varies with concentration:
low bacteriostatic (interfere with cell membrane;leakage)higher bactericidal (coagulation of cell contents)
what systems can chlorohexidine be toxic too
neurotoxicototoxic (middle ear)ocular damage
characteristics of triclosan antiseptics
phenol familycauses cell wall disruptionbacteriostatic (less effective than povidone and chlorohex)
use of a razor for clipping as opposed to clippers
associated with higher incidences of SSI
what % of skin flora remains protected in deeper skin layers/ follicles even after clip and sterile prep
20%
contact times for surgical preps
30 s chlorohexidine2 minutes povidone iodine