13 GI inflammatory diseases

Question 1

What are the 2 main causes of diarrhoea?

Answer 1

acute infection (gastroenteritis)
chronic diarrrhoea

Question 2

What are the subdivisions of gastroenteritis?

Answer 2

inflammatory/bloody
non-inflammatory
food poisoning

Question 3

What are the subdivisions of chronic diarrhoea?

Answer 3

osmotic
secretory
inflammatory
malabsorptive
chronic infections
motility disorders

Question 4

If someone has acute gastroentiritis in the uk, what should we be looking out for?

Answer 4

food poisoning
infections
drug induced (non-steroidal anti-inflammatories)
chemicals -alcohol

Question 5

Name one Virus, and 2 bacteria causing acute gastroentiris

Answer 5

Adenovirus

E.Coli and Salmonella

Question 6

Which areas does Crohn’s diseases affect?

Answer 6

end of ileum and beginning of colon, all layers

Question 7

What areas Ulcerative Colitis affect?

Answer 7

the entire colon, but normally just the inner layer

Question 8

Out of UC or Chron’s, which more commonly produces fistulae?

Answer 8

Crohn’s

Question 9

What kind of drugs would you use for long-term management of IBD?

Answer 9

Anti TNF-alpha antibodies (like infliximab or adalimumab)

Question 10

How would you surgically treat Crohn’s, why is there a problem?

Answer 10

segmental resections, but there is a high risk of disease in the remaining bowel

Question 11

How would you treat UC surgically?

Answer 11

severe: sub-total colectomy
elective: panproctocolectomy with ileo-anal pouch