11. BIOMEDICAL DISCOVERIES Flashcards

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1
Q
  1. Who is Hippocrates?
A
  • he is the father of Medical Research
  • he lived in 400 BC
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2
Q
  1. Name the 3 articles Hippocrates wrote on Epidemiology.
A
  1. Epidemic I
  2. On Airs, Waters and Places
  3. Epidemic III
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3
Q
  1. What did Hippocrates do?
A
  • he coined the term Epidemiology
  • he coined the term Epidemic
  • he determined and described the diseases which occur
    in specific places at specific time periods
  • he introduced the concept of the Risk Factor
  • he suggested that each disease is caused by a different
    risk factor
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4
Q
  1. Who is James Lind?
A
  • he is a British Military Surgeon in the Scottish and
    Royal Navies
  • he lived from 1716-1794
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5
Q
  1. What did James Lind observe?
A
  • he observed that British sailors were suffering from
    Scurvy during long trips
  • no one at this time could identify the aetiology
  • Lind observed that sailors were consuming very poor
    diets that lacked in fresh fruit
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6
Q
  1. What did Lind Hypothesise?
A
  • he hypothesised that the disease will disappear if he
    gave limes to the soldiers
  • he conducted the first ever Clinical Trail in 1747
  • he proved that scurvy was caused by a lack of citrus
    fruits
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7
Q
  1. Who was John Snow?
A
  • he was a British Physician
  • he lived from 1813- 1858
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8
Q
  1. What happened in London in 1849?
A
  • a major outbreak of Cholera
  • it leads to around 15 000 deaths
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9
Q
  1. What did Snow Propose?
A
  • he proposed that people were infected with Cholera by
    swallowing something that multiplied in the intestines
  • he observed and investigated this case
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10
Q
  1. What did John Snow’s findings reveal?
A
  • Cholera cases were more common in areas that were
    supplied from the banks of the river Thames
  • this is because it was polluted by Sewage
  • the upstream waters were non-polluted
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11
Q
  1. How did John Snow prove his theory?
A
  • he conducted an experiment
  • he did this by sealing a water pump in a highly infected
    neighbourhood
  • Cholera disappeared from the neighbourhood
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12
Q
  1. What did Jenner observe?
A
  • he observed that Milkmaids who had previously
    contracted cowpox were now protected from smallpox
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13
Q
  1. What did Jenner hypothesise?
A
  • the exposure to cowpox could protect against smallpox
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14
Q
  1. How did Jenner test his hypothesis?
A
  • he performed specific experiments
  • he took material from a Cowpox sore on a milkmaid’s
    hand
  • he inoculated it into the arm of the 9 year old son of
    Jenner’s gardener
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15
Q
  1. What happened months later to the 9 year old boy?
A
  • he was exposed several times to the Variola virus
  • he never developed smallpox
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16
Q
  1. What is the Scientific method?
A
  • this is the process by which the scientific community
    endeavours to construct a representation of various
    world phenomena

THIS REPRESENTATION HAS TO BE:
- reliable
- consistent
- non-biased
- accurate

17
Q
  1. What 5 Steps does the Scientific Method Comprise of?
A
  1. Observation (Literature Review)
  2. Devising a Testable Research Question
  3. Formulating a specific hypothesis
  4. Testing the hypothesis with an experiment or analysis
  5. Deriving a conclusion
    (this is where you reject or accept your hypothesis)
18
Q
  1. Does this figure make sense?
A
  • yes
19
Q
  1. What are the 2 main purposes of Biomedical Research?
A
  1. Evidence-Based Medicine (EBM)
  2. Disease Prevention
20
Q
  1. What is Evidence-Based Medicine (EBM)?
A
  • the process of systematically reviewing, appraising and
    using current best evidence from clinical research
    findings
  • this aids the delivery of Optimum Clinical Care to
    patients
21
Q
  1. What is Disease Prevention?
A
  • this is the identification of risk factors and protective
    factors of different diseases
  • this enables public health programmes that aim at
    preventing diseases
22
Q
  1. What are the 6 types of Biomedical Research?
A
  1. IN VITRO STUDIES
    (lab-based research)
  2. STUDIES ON ANIMAL MODELS
  3. SMALL-SCALE STUDIES IN HUMANS
  4. LARGE-SCALE OBSERVATIONAL EPIDEMIOLOGICAL
    STUDIES IN HUMANS
    • cross sectional
    • case control
    • cohort
  5. LARGE-SCALE INTERVENTIONAL STUDIES IN HUMANS
    • clinical trials
  6. SYSTEMATIC REVIEWS AND META-ANALYSES