10. chronische lymphatische Leukämie Flashcards

1
Q

(CLL)

Definition

A

indolentes B-Zell-Non-Hodgkin-Lymphom

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2
Q

(CLL)

Epidemiologie

A

häufigste Leukämieform

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3
Q

(CLL)

Leitsymptome (2)

A
  • B-Symptomatik
  • chronische Pruritus und Urtikaria
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4
Q

(CLL)

Befunde (2)

A
  • indolente Lymphadenopathie
  • Splenomegalie
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5
Q

(CLL)

Labortests (3)

A
  • Blutbild
  • Blutausstrich
  • Immunphänotypisierung
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6
Q

(CLL)

Blutbild: Befund

A

Leukozytose mit hohem Lymphozytenanteil

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7
Q

(CLL)

Blutausstrich: Befund

A

reife, kleine Lymphozyten

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7
Q

(CLL)

Immunphänotypisierung: Befund

A

Nachweis von B-CLL-Immunphänotyp (CD19, CD20, CD23)

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8
Q

(CLL)

Klassifikation

A

Binet-Klassifikation

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9
Q

(CLL)

Binet-Klassifikation: Stadien

A

A, B und C

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10
Q

(CLL)

Stadium B: Therapieindikation

A

symptomatische Patienten

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10
Q

(CLL)

Stadium A: Therapieindikation

A

nur in Einzelfällen

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11
Q

(CLL)

Stadium C: Therapieindikation

A

alle Patienten

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12
Q

(CLL)

Therapie: Arzneistoffe (3)

A
  • Purinanaloga
  • Alkylazien
  • AK
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