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Hämatologie > 9. chronische Myeloische Leukämie > Flashcards

9. chronische Myeloische Leukämie Flashcards

1
Q

(CML)

Genetik

A

BCR-ABL-Fusionsgen

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2
Q

(CML)

Befunde (2)

A

hochgradige Splenomegalie (eher keine Lymphadenopathie!)

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2
Q

(CML)

Pathophysiologie

A

Philadelphia-Translokation - t(9;22)

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3
Q

(CML)

Leitsymptome (2)

A
  • chronische Fatigue
  • B-Symptomatik
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4
Q

(CML)

Laborbefunde (3)

A
  • Anämie
  • Thrombozytopenie
  • extreme Leukozytose
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5
Q

(CML)

Diagnosesicherung

A

Knochenmarkaspirat und -Biopsie

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6
Q

(CML)

Therapie der Wahl:

A

Tyrosinkinaseinhibitoren (TKI)

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6
Q

(CML)

Knochenmarkaspirat und -Biopsie: Befund

A

zytogenetischer Nachweis des Philadelphia-Chromosoms

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7
Q

(CML)

TKI

A

“tinib”

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8
Q

(CML)

Therapie der 2. Wahl

A

allogene Stammzelltransplantation

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Hämatologie (12 decks)

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