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Hämatologie > 4. Non-Hodgkin-Lymphome > Flashcards

4. Non-Hodgkin-Lymphome Flashcards

1
Q

(NHL)

Sonderformen (3)

A
  • follikuläres Lymphom (Keimzentrumslymphom)
  • Haarzellleukämie
  • Burkitt-Lymphom
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2
Q

(NHL)

follikuläres Lymphom: Ätiologie

A

Translokation t(14,18)

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3
Q

(NHL)

follikuläres Lymphom: Histologie

A

zahlreicher große unscharf begrenzte follikuläre Strukturen

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4
Q

(NHL)

Haarzellleukämie: Labor

A

Panzytopenie

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5
Q

(NHL)

Haarzellleukämie: Blutausstrich

A

Nachweis von Haarzellen im peripheren Blut

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6
Q

(NHL)

Haarzellleukämie: Therapie

A

Chemotherapie mit Purinanaloga

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7
Q

(NHL)

Burkitt-Lymphom: Charakteristik

A

sehr aggressiv

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8
Q

(NHL)

Leitsymptome (2)

A
  • B-Symptomatik
  • schmerzlose Lymphadenopathie
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8
Q

(NHL)

Assoziation des endemischen Burkitt-Lymphoms

A

EBV

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9
Q

(NHL)

Befund

A

Splenomegalie

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10
Q

(NHL)

Laborbefund

A

Panzytopenie

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11
Q

(NHL)

Diagnosesicherung (2)

A
  • Lymphknotenexstirpation
  • Immunhistochemie
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12
Q

(NHL)

Immunhistochemie: B-Zell-Lymphome

A

CD20+

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13
Q

(NHL)

negative prognostische Faktoren (5)

A
  • Alter > 60 J.
  • LDH erhöht
  • Stadium III-IV
  • Who-Status > 2
  • > 1 extranodaler Befall
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14
Q

(NHL)

Immunhistochemie: T-Zell-Lymphome

A

CD3+

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15
Q

(NHL)

Maliginität (2)

A
  • niedrigmalignes NHL (indolentes)
  • hochmalignes NHL
16
Q

(NHL)

niedrigmalignes NHL: Therapieintention der Stadien I und II

A

kurativ

17
Q

(NHL)

niedrigmalignes NHL: Therapie der Stadien I und II

A

Radiatio

18
Q

(NHL)

niedrigmalignes NHL: Therapieintention der Stadien III und IV

A

palliativ

19
Q

(NHL)

niedrigmalignes NHL: Therapiemöglichkeiten der Stadien III und IV (2)

A
  • “Watch and Wait”
  • Polychemotherapie
20
Q

(NHL)

Polychemotherapie: Schema

A

CHOP

21
Q

(NHL)

Polychemotherapie: Schema bei B-Zell-NHL

A

R-CHO

22
Q

(NHL)

hochmalignes NHL: Therapieintention

A

kurativ

23
Q

(NHL)

hochmalignes NHL: Therapie

A

Polychemotherapie

Hämatologie (12 decks)

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