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Hämatologie > 1. multiples Myelom > Flashcards

1. multiples Myelom Flashcards

1
Q

(MM)

Epidemiologie

A

dritthäufigste hämatologische Neoplasie

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2
Q

(MM)

Stadieneinteilung: Parameter (4)

A

1-Albumin

2-β2-Mikroglobulin

3-LDH

4-Zytogenetik

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3
Q

(MM)

Diagnostik: Hautpkriterien (2)

A
  • > 10% klonale Plasmazellen im Knochenmark

ODER

  • biopsiegesichertes Plasmozyton
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4
Q

(MM)

Nebenkriterien (7)

A

SLiM-CRAB

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5
Q

(MM)

SLiM: S?

A

S = 60%

> 60% klonale Plasmazellen im Knochenmark

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6
Q

(MM)

SLiM: Li?

A

Li = Light Chain Ratio

Quotient involvierte/nichtinvolvierte freie Leichtketten > 100

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7
Q

(MM)

Konsequenz der erhöten Light Chain Ratio

A

Amyloidose

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8
Q

(MM)

SLiM: M?

A

M = MRT

mindest. 1 fokale Läsion > 5 mm im Ganzkörper-MRT

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9
Q

(MM)

CRAB: C?

A

C = Calzium

  • Serumkalzium > 11 mg/dl oder
  • Überschreitung der oberen Grenze des Normbereichs um 1 mg/dl
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10
Q

(MM)

CRAB: R?

A

R = renale Insuffizienz

  • Serumkreatinin > 2 mg/dl oder
  • GFR < 40 ml/min
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11
Q

(MM)

CRAB: A?

A

A = Anämie

  • Hb < 10 g/dl oder
  • Unterschreitung der unteren Grenze des Normbereichs um > 2 mg/dl
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12
Q

(MM)

CRAB: B?

A

B = Bone Lesions

  • osteolytische Läsionen im Röntgen oder CT
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13
Q

(MM)

typischer Röntgen-Befund

A

Schrotschussschädel

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14
Q

(MM)

supportive Therapie

A

Strahlentherapie

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15
Q

(MM)

kurative Therapie

A

Chemotherapie mit autologer Stammzelltransplantation (HMAS)

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16
Q

(MM)

HMAS: Phasen (3)

A

1-Induktionsbehandlung

2-autologe Stammzellentnahme

3-autologe Stammzellinfusion

17
Q

(MM)

Induktionsbehandlung: Chemotherapeutika

A

3-6 Zyklen mit Bortezomib und Dexamethason

18
Q

(MM)

Induktionsbehandlung: Kombinatiostherapie

A

Lenalidomid, Cyclophosphamid oder Thalidomid

19
Q

(MM)

autologe Stammzelltransplantation: Zeitpunkt

A
  • 2-8 Wochen nach der Induktionsbehandlung
20
Q

(MM)

autologe Stammzellentnahme: Nachbehandlung

A

hochdosierte Mephalan

Hämatologie (12 decks)

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