(1) Anatomy and Histology of the Periodontium - periodontal ligament (ground substance, cells, nerve and blood supply) Flashcards
What secretes the ground substance?
fibroblasts
What is the role of the fibroblasts?
cells responsible for forming the collagen for collagen fibres
What are the components of the ground substance?
- Hyaluronate glycosaminoglycans.
- Proteoglycans
- Glycoproteins
What are the proteoglycans comprising the ground substance?
1) Proteodermatan sulphate
2) PG1 (contains hybrids of chondroitin sulphate dermatan sulphate).
What are the glycoproteins which comprise the glycoproteins?
1) fibronectin
2) tenascin
What is the role of the ground substance in the periodontal ligament?
maintain pressure and function of the PL
Name the 6 types of cell in the periodontal ligament
- Fibroblasts
- Cementoblasts.
- Osteoblasts
- Osteoclasts and cementoclasts.
- Epithelial cells
- Immune cells
What is the role of fibroblasts in the PL?
Form fibres
Responsible for the regeneration of the periodontal ligament.
Role in adaptive responses to mechanical loading.
What is the shape of the fibroblasts?
vary
don’t always see the spindle shape
prominent nucleoli
Are fibroblasts active or inactive?
active
lots of synthesising organelles
Fibroblasts produce collagen, what else do they do with regard to collagen?
Collagen degradation (fibroblasts are also fibroclastic).
Apart from collagen, what other substances do fibroblasts secrete secrete?
- matrix metalloproteinases
- tissue inhibitors
- metalloproteinases.
What is the role of collagen?
help maintain the structural framework of tissues.
What regulates collagen production from fibroblasts?
Collagenase production is regulated by exposure of cytokines.
Where do cementoblasts line?
the outer surface of the cementum
Are cementoblasts active?
Yes, but produce cementum at a very slow pace
What is formed at a higher rate, acellular or cellular cementum?
cellular
Where are osteoblasts located?
line the alveolar bone
line the tooth socket
What is the role of osteoblasts?
form bone
protein synthesising organelles
prominent where there is active bone formation
active protein formation
What do osteoblasts look like when they are active/inactive?
active = basal round nucleus
inactive = flat