Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Renal > 05.22 - Renal Neoplasia (Handorf) - PP + Handout > Flashcards

05.22 - Renal Neoplasia (Handorf) - PP + Handout Flashcards

1
Q

WAGR and Denys-Drash are both associated with abnormalities of

A

Wilms Tumor 1 gene

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Malignant neoplasm composed of cells with clear or eosinophilic cytoplasm w/in delicated vascular network

A

Clear Cell RC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

2 different appearances of Papillary Carcinoma depending on angle of section

A

Nipples vs Papillae

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Small renal cortical papillary neoplasms

A

Very common, look just like renal papillary carcinomas under microscope

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Does RCC spread better hematogenously or by lymph

A

About equal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Most common type of renal cell carcinoma

A

Clear cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Which subtype is more prone to bilateral or multifocal tumors

A

Papillary

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Beckwith-Wiedemann Syndrome is associated with

A

loss of genetic imprinting that normally silences allele controlling ILGF2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

loss of genetic imprinting that normally silences allele controlling ILGF2

A

Beckwith-Wiedemann Syndrome is associated with

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is helpful to radiologists in dx oncocytoma

A

Central Stellate Scar

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Risk factors and average age for renal cell carcinoma

A

Smoking, HTN, Obesity - 64 years

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

3 congenital malformations associated with Wilms Tumor

A

WAGR Syndrome, Denys-Drash, Beckwith-Wiedemann

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Large pale cells with prominent cell membranes

A

Chromophobe Carcinoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Origin of Renal Cell Carcinoma

A

Renal Tubular Epithelium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Papillary Renal Cell Carcinoma

A

Short nipple-like or long finger-like projections of tumor cells in fibrovascular stalk

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Behavior of Oncocytoma

A

Benign

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Chromophobe Renal Cell Carcinomas

A

Large pale cells with prominent membranes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Chromophobe RCC is positive for

A

Hale’s colloidal iron stain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Genetic signature of Oncocytoma

A

None

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Abundant cytoplasmic little red bacteria-size dots

A

Mitochondria in Oncocytoma

16
Q

What is predictably common in renal cell carcinomas

A

Hemorrhage - tumoral blood vessels are abnormal and prone to rupture

16
Q

Genetics of Papillary RCC

A

MET mutation

18
Q

Where do Renal Cell Carcinomas spread

A

Perinephric Fat, Lungs, Bone, Lymph Nodes

19
Q

Uncommon benign epithelial neoplasms arising from intercalated cells of CD

A

Oncocytoma

20
Q

Why do CCC’s appear cystic

A

Liquefactive necrosis

21
Q

MET mutation

A

Genetics of Papillary RCC

22
Q

Oncocytoma

A

Uncommon benign epithelial neoplasms arising from intercalated cells of CD

24
Q

Mahogony Brown kidney mass

A

Oncocytoma

25
Q

Wilm’s tumor is composed, microscopically, of

A

a mixture of cellular elements: blastemal, stromal, epithelial

26
Q

Very common, look just like renal papillary carcinomas under microscope

A

Small renal cortical papillary neoplasms

27
Q

What causes “empty” appearance of CCC on US

A

Liquefaction

29
Q

vHL mutations

A

Clear Cell Renal Carcinoma

30
Q

Small round blue cells, abortive tubules or glomeruli, fibroblastic stromal cells, and anaplastic cells

A

Wilms Tumor is composed of

31
Q

Which subtype of Renal Cell Carcinoma has best prognosis

A

Chromophobe (aneuploidy)

33
Q

Most common presentation of Wilms tumor

A

Abdominal mass

34
Q

Clear Cell Carcinoma cells may form

A

Abortive Tubules

36
Q

Grossly mahagony brown w/ central stellate scar

A

Oncocytoma

37
Q

Wilms Tumor is composed of

A

Small round blue cells, abortive tubules or glomeruli, fibroblastic stromal cells, and anaplastic cells

38
Q

Activating mutations in MET –> TKR for HGF

A

Papillary Renal Cell Carcinoma is associated with what mutations

39
Q

Mutations in Clear Cell Carcinoma and consequence

A

vHL -> excess HIFs lead to excess VEGF

40
Q

Clear Cell Carcinoma is composed of cells with ____ corrleated with ___ apparent grossly

A

Vacuolated (lipid-laden) cytoplasm, correlated with yellow color grossly

41
Q

Short nipple-like or long finger-like projections of tumor cells in fibrovascular stalk

A

Papillary Renal Cell Carcinoma

42
Q

Why does CCC have delicate vascular network

A

VEGF/vHL

43
Q

Second and Third Most common types of Renal Cell Carcinoma

A

Papillary and then Chromophobe

45
Q

Central Stellate Scar

A

Oncocytoma

46
Q

Papillary Renal Cell Carcinoma is associated with what mutations

A

Activating mutations in MET –> TKR for HGF

47
Q

Acquired dialysis related renal cystic disease

A

60% clear/ 40% papillary

48
Q

Positive for Hale’s colloidal iron stain

A

Chromophobe Carcinoma

49
Q

First and Second most frequent presenting symptom of RCC

A

Hematuria, Dull Flank Pain

Renal (31 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions