05.15 - HTN (Gosmanova) - PP, No reading Flashcards

1
Q

Increase NaCl delivery to MD increases ___ production

A

Adenosine

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1
Q

Wet HTN

A

Essential with Low Renin

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1
Q

Mechanism of Volume Expansion in Glucocorticoid Excess (Cushing’s)

A

Cortisol excess activates ENaC (same as aldosterone)

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1
Q

Gordon Syndrome is characterized by

A

Salt-sensitive HTN, HyperK, Metabolic Acidosis

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2
Q

Individuals from INTERSALT had higher ___ compared to rural populations

A

Average systolic and Diastolic BP

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3
Q

Tx for Genetic PseudoHypoAldosteronism

A

Triamterene Amiloride

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4
Q

Which activate and which inhibit Renin: B1 rec, Adenosin2 rec, Prostaglandin rec

A

B1 and PG activate, Adenosin2 inhibits

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4
Q

Activating WNK-1 and Inactivating WNK-4 both cause

A

Increased activity of NaCl channel and incr Na reabsoprtion (Gordon’s)

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5
Q

Gene mutation leading to Aldosterone Synthetase responsive to ACTH

A

Glucocorticoid Remediable Aldosteronism

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6
Q

Ouabain acts on

A

Na/K ATPase

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6
Q

Infusion of Saline in normal kidney patient vs anephric

A

Small changes of BP in normal; rapid rise in anephric

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6
Q

Dry HTN

A

Essential with High Renin

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7
Q

Pressure-Natriuresis: ___ is mediator

A

Changes in interstitial medullary pressure

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7
Q

% of HTN and Normotensive individuals with salt sensitivity

A

50 and 26

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7
Q

Gordon Syndrome is due to

A

Constitutive activation of Thiazide-Sensitive NaCl channels in DCT

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9
Q

Inability of kidneys to appropriately excrete Na load

A

Guyton’s theory

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11
Q

Increase in CO in Essential HTN

A

does not persist

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12
Q

Effect of Ouabain on SVR and Venous Tone

A

Increases SVR and Venous Tone

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12
Q

Brenner’s Hypothesis

A

Reduction in Nephron Mass

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12
Q

Decrased NaCl delivery to MD increases ___ production

A

NO and PG

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12
Q

All forms of Secondary HTN are characterized by

A

Salt-sensitive HTN

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13
Q

Ignores role of ANS: Fails to explain incr BP in pre-HTN, where CO incr is mainly driven by SNS activaiton

A

Cons of Guyton’s Theory

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14
Q

Mechanisms of Salt’s role in HTN

A

Dec Na excretion, Incr SNS activity, Incr activity of Na-H exchanger, Incr Ca in vascular SM cells

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15
Q

Laragh’s Hypothesis

A

Some nephron’s are ischemic and produce high renin, while others are not but will have impaired natriuresis from AT2 - Total PRA is diluted/normal

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15
Tx for Liddle's
Triamterene or Amiloride
16
Does salt-sensitivity change with age
Yes, increases
17
Renin and Aldosterone in Secondary HTN
Low Renin and Aldosterone, except Aldosterone Excess obv
18
Liddle's disease is due to
Activating ENaC mutation
19
Psuedohypoaldosteronism Type 2 is aka
Gordon Syndrome
20
Cause of Liddle's Syndrome
Constitutive activation of ENaC in DT due to mutaiton in subunit
22
Decr Na excretion leading to Incr CO is corrected by autoregulation at expense of
Incr SVR and BP
23
Causes of PseudoHypoAldosteronism (non-Liddle's)
11B-HSD-2 Defiency of Inhibition
24
Action of 11B-HSD-2
Breaks down Cortisol
25
Volume and Renin in Goldblatt Model 1
Renin is high, but volume is normal b/c contralateral kidney is able to excrete excess Na
26
Change in Pressure-Natriuresis curve with salt-sensivity
Decrease in slope
27
Worsening condition after ACEi =
Highly suggestive of Bilteral RAS
28
How does Pseudohypoaldosteronism cause Hypokalemia
Incr Na reabsorption in CD creates favorable gradient for K secretion
30
Ouabain is activated by
Incr PV
31
What channel is upregulated in Aldosterone excess that contributes to HTN
ENaC channel reabsorbs Na in CD
32
Role of Genetics in HTN
70-80% of individuals have positive family history
32
Channel upregulated in Cushing's that contributes to BP increase
ENaC channel reabsorbs Na in CD
33
Goldblatt Model 1
Unilateral RAS w/ 2 normal kidneys - Incr SVR and Right shift in pressure natriuresis - Normal volume
35
Inc Pre-Load can be due to
Incr Venous Tone or Incr Volume (and therefore total Na)
36
What inhibits 11B-HSD-2
Chronic licorice ingestion (candies, chewing tobacco)
37
ACEi's in Goldblatt Model 1
Reduce BP b/c stenotic kidney is secreting renin
38
As CKD progresses, revalance of HTN \_\_\_
rises
38
ACEi's in Goldblatt Model 2
Will not help - In fact, they'll reduce GFR - RAAS necessary to maintain GFR in this scenario
40
Renin levels in Essential HTN
20% high, 30% low, 50% normal
42
MAP = CO x SVR =
DBP + 1/3(SBP-DBP)
43
Guyton's theory
Inability of kidneys to appropriately excrete Na load
45
Pressure-Natriuresis: Changes in Na excretion occur without
changes in GFR
46
Deficiency in 11B-HSD-2 leads to excess
Cortisol
47
Activating ENaC mutation
Liddle's disease is due to
48
2 mutations that cause Gordon's
Activation of WNK-1, Inactivaiton of WNK-4
49
Volume and Renin in Goldblatt Model 2
Both high
51
Goldblatt Model 2
Biltateral RAS - No off-setting pressure natriuresis
52
Reduction in Nephron Mass --\> ___ --\> \_\_\_
Systemic/Glomerular HTN --\> Acquired Glomerular Sclerosis
53
Cause of Hyperkalemia in Gordon's
Reduced distal Na delivery, so decreased K secretion
55
No salt, no \_\_\_, even with \_\_\_\_
No salt, no HTN, even with aging
57
Age of onset for primary HTN
40s and 50s
58
Aloows for normal BV despite elevated pressure
Pros of Guyton's Theory
59
Pressure-Natriuresis: ___ is the principal site
Outer Medulla (TALH)
60
What is necessary to maintain GFR in Goldblatt Model 2
RAAS, so ACEi's are contraindicated
62
Most common causes of RAS
Atherosclerosis (85%), Fibromuscular Dysplasia (15%)
63
K and Acid-Base in Secondary HTN
All associated with Hypokalemia and Metabolic Alkalosis except Gordon Sydnrome
64
Inactivating mutations in 11B-HSD-2 gene
Apparent Mineralocorticoid Excess is due to
65
2 factors that activate renin release from JGA in response to Renal hypoperfusion
Decr afferent artiolar stretch, Decr NaCl delivery to Macula Densa
67
T/F: We are all salt-sensitive to some degree
FALSE
68
SV can be increased by
Incr in Pre-Load or Contractility
69
Pros of Guyton's Theory
Aloows for normal BV despite elevated pressure
70
What normally degrades Cortisol
11B-HSD2
71
Is peripheral edema common in essential HTN
No
72
Does Adenosine vasoconstrict or dilate
Vasoconstrict
73
Apparent Mineralocorticoid Excess is due to
Inactivating mutations in 11B-HSD-2 gene
74
Prevalence of RAS is higher with
age, DM, PVD, DBP \>125
75
Gordon's Syndrome mimics
Gitelman's
76
How does PseudoHypoAldosteronism cause Metabolic Alkalosis
Hypokalemia causes shift of H+ into tubular cells and then secretion into lumen; Also incr H+ secretion by H pump
77
What is Pressure Natriuresis
When perfusion press incr., renal Na output incr and ECFV and BV contract to return MAP to baseline
79
Local factor autoregulation is mediated primarily by
NO
80
Tx of Gordon's Syndrome
Thiazide Diuretics
81
Cons of Guyton's Theory
Ignores role of ANS: Fails to explain incr BP in pre-HTN, where CO incr is mainly driven by SNS activaiton