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Renal > 05.06 - RBF, GFR (Rao) - PP, Lecture Guide, No reading, Not watched > Flashcards

05.06 - RBF, GFR (Rao) - PP, Lecture Guide, No reading, Not watched Flashcards

1
Q

What effect on net filtration pressure does lower urinary tract obstruction have?

A

Increase Pbs –> Decrease GFR

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1
Q

How does sympathetic activation affect Resistance, RPF, GFR

A

Constriction of Aff and Eff -> Dec RPF and Pg -> Dec GFR

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1
Q

How does Ang 2 affect renal arteriolar resistance and GFR

A

Induces renal arteriolar constriction and reduces GFR, paradoxically opposing auto regulation

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2
Q

How does Sympathetic affect Kf

A

Decrease Kf by stimulating mesangial cells -> Dec GFR

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3
Q

How does DM affect GFR

A

Decreases Kf, so decreases GFR

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3
Q

Higher NaCl at MD =

A

Inc Afferent Arteriolar R -> Dec GFR

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3
Q

Proteinuria can either be from barrier failure or ___

A

Abnormal Circulating Protein (breakdown of tissue, production of abnormal proteins)

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4
Q

How does dec Cl in DT affect Renin

A

Inc Renin -> Inc Ang II, etc

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5
Q

Net Filtration Pressure =

A

(Pg + Pibs) - (Pig + Pbs)

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7
Q

How does Uretral Obstruction affect GFR, FF?

A

Reduce GFR and thus FF

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7
Q

Kf =

A

Filtration Coefficient = Hydraulic Conductivity x SA of Glomerular Capillaries

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7
Q

Mechanism of GFR Autoreg: Dec GFR ->

A

Dec Cl in distal tubule -> MD -> Dec Arteriolar Resistance -> Inc GFR

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7
Q

When is Autoregulation more important vs Sympathetics

A

Autoregulation dominates under normal conditions; Sympathetics only under severe ECFV loss

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8
Q

How does Endothelin affect GFR

A

Constrict Arterioles (aff and eff) -> Dec GFR

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9
Q

How do sympathetics control renin

A

B1 receptors stimulate renin in JG cells

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11
Q

2 locations where hydrostatic pressure drops

A

Afferent Arteriole; Efferent Arteriole/Peritubular Capillary

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14
Q

Size of Albumin

A

6nm or 60 angstroms

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14
Q

How does Low Capillary Flow affect FF, Pig, Net filtration pressure, GFR

A

Inc FF -> Inc Pig -> Dec Net Filtration Press -> Dec GFR

14
Q

T/F: Autoregulation in kidney depends on sympathetic input?

A

False, isolated in kidney

16
Q

GFR =

A

Kf x Net filtration pressure

17
Q

Lower NaCl at MD =

A

Dec Afferent Arteriolar R -> Inc GFR

18
Q

Two Theories of Autoregulation

A

Myogenic, Tubuloglomerular Feedback

19
Q

Adrenaline vs Endothelin 1 on resistance

A

Adrenaline is perferentially for Afferent, Endothelin does both

20
Q

How does decreased efferent resistance affect GFR, RPF

A

Decreased GFR, Increased RPF

21
Q

How does Adrenaline affect GFR

A

Constrict Arterioles (preferentially afferent) -> Dec GFR

23
Q

Normal GFR is __ mL/min, ___ L/day

A

130 mL/min; 180 L/day

24
Q

Size of glomerular pores

A

8nm or 80 angstroms

24
Q

How does increased efferent resistance affect GFR, RPF?

A

Increase GFR, Decrease RPF

25
Q

Hydraulic Conductivity x SA of Glomerular Capillaries

A

Kf (Filtration Coefficienty)

26
Q

How does Renal Artery Stenosis affect RPF, FF?

A

Reduces RPF, thus increases FF

27
Q

Anions and Cations in Glomerulus vs Ultrafiltrate

A

4-5% more anions in ultrafiltrate and 4-5% less cations - Gibbs Donnan effect

28
Q

What is the filtration fraction?

A

GFR / RPF

30
Q

How does decreased Afferent resistance affect GFR, RPF

A

Increase GFR, RPF

32
Q

How does increase Afferent resistance affect GFR, RPF?

A

Decrease GFR, RPF

33
Q

When does sympathetic response act on nephron?

A

Overrides autoregulation in severe ECFV loss

35
Q

What does the Tubuloglomerular feedback mechanism sense

A

NaCl at Macula Densa

36
Q

Alternate route that Inc GFR -> Inc Arterolar R

A

Inc GFR -> Inc Cl in DT -> Na-K-Cl in MD cells -> Release ATP or AA metabs -> SM contraction -> Inc Art R

37
Q

How does NO affect GFR?

A

Decreased Vascular R -> Inc GFR

38
Q

How does pressure affect renin release

A

Increased pressure in afferent arteriole inhibits renin release from JG cells; Vice versa

40
Q

How do PG’s affect GFR?

A

Decreased Vascular R -> Inc GFR

41
Q

The kidneys receive what percent of cardiac output?

A

20%

42
Q

Source of Endothelin that affects GFR?

A

Damaged endothelial cells

43
Q

Mechanism of GFR Autoreg: Inc GFR ->

A

Inc Cl in distal tubule -> MD -> Inc Arteriolar Resistance -> Dec GFR

Renal (31 decks)

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