Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Renal > 05.07 - Reg of Body Fluid (Rao) - PP, LG, No reading, Not watched > Flashcards

05.07 - Reg of Body Fluid (Rao) - PP, LG, No reading, Not watched Flashcards

1
Q

What percent of filtered load of Na is reabsorbed in LOF? DCT/CD?

A

28%, 7%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

What increases ANP

A

Atrial Stretch; Plasma Pna increase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Renal Na excretory system responds __ to changes in Na input

A

Relatively slowly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

ECFV =

A

(Amount of ECF Na) / Pna

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What ion is lost in diarrhea

A

HCO3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Where are Neural Stretch Receptors

A

In large veins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Response to increases in arterial pressure on urinary Na excretion in Isolate Kidney scenario

A

2-3 fold increase in Na output by 30-50 mmHg change in arterial pressure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Effect of changes in pressure on Na excretion in Isolated Kidney vs Intact System

A

Takes very large increase in pressure in isolated kidney, but only a very small increase in pressure in intact system

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Change in BW over short period indicates

A

Change in Na balance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

3 Actions of ANP

A

(1) Dilation of Aff, Constriction of Eff - Inc GFR; (2) Inhibit Aldo secretion; (3) Inhibit Na channel phosphorylation in DT/CD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

How do burn patients get edema

A

Inc Endothelial permeability -> Flux of Albumin and Fluid into ISF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Effect of ANP on Afferent and Efferent Arterioles

A

NPR1 causes dilation of Afferent, but constriction of Efferent -> Inc GFR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Primary Diabetes Insipidus is associated with low plasma

A

ADH level

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

ECFV is directly proportional to

A

Total Body Na content

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

How do ECF, Sympathetic, Renal Arterial BP affect Renin release

A

Decreased ECFV, Increased Sympathetic firing, Decreased Renal Arterial BP all increase Renin release from JG Cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Pna =

A

(Amount of ECF Na) / ECFV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

At constant Pna, ECFV = ____

A

Amount of ECF Na+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

How long does it take to restore water balance after drinking 1 L pure water (change in plasma osmolarity)

A

1-2 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Timeframe of Aldosterone effect on Na reabsorption

A

Slow, not likely to play a role in rapid regulation of Na excretion

15
Q

How is Aldosterone release affected by K, Angiotensin, and Na

A

Release stimulated by plasma K and Angiotensin; Inhibited by plasma Na

16
Q

How do changes in GFR affect Na excretion

A

Increase in GFR increases Filtered Load and amount of Na excreted

17
Q

ANP has exact opposite effect of

A

Aldosterone

18
Q

3 causes of Na imbalance

A

Diarrhea, Excessive Sweating, Diuretics

18
Q

Change in ECFV in response to Na intake is also

A

Slow

19
Q

Receptors for ANP

A

NPR1/2 - Guanylate Cyclase cGMP mechanism

21
Q

How does natriuetic hormone affect Na reabsorption

A

Decreases reabsorption -> Promotes excetion of Na and H20

22
Q

3 Major “Hypovolemic Hormones”

A

AVP, Renin, NE

23
Q

PV determines mean circulatory filling pressure, and therefore __

A

CO

24
Q

Effect of Ouabain like factor

A

Diuresis and Natriuresis

25
Q

Nephrongenic Diabetes Insipidus is associated with elevated

A

Plasma ADH

27
Q

What does the difference in effect of arterial pressure on Na excretion in Isolated vs Intact systems suggest?

A

Pressure natriuresis is synergized with reduced formation of renin, ang 2, and aldosterone

28
Q

How does ANP decrease Na reabsorption

A

In DCT via NCC; In CD via cGMP-mediated ENaC phosphorylation

30
Q

Timeframe of balance restoration after ingestion of water vs isotonic saline

A

Water changes osmolarity, 1-2 hours corrected; Isotonic saline increases total Na, 2-4 days corrected

32
Q

Is sweat isotonic?

A

No

34
Q

Is vomit isotonic?

A

Yes

36
Q

Change in Pna occurs only when

A

Gain or Loss of Na exceeds thirst mechanism and kidney’s ability to correct

37
Q

Activation of Arterial Baroreceptors –>

A

Pituitary –> AVP

38
Q

Auscultation signs of edema

A

S3, Pulmonary Edema

39
Q

How does Angiotensin 2 Increase Na Reabsorption

A

Proximal Na:H exchanger

41
Q

Edema requires ECF increase of

A

2.3-3 L

41
Q

Normal Blood Volume? Volume that causes Edema? Death?

A

15, 20-25, 10-12

42
Q

Atrial Stretch Receptor Activation –>

A

Signal via Vagus -> Sympathetic to kidneys, ANP, decreased AVP?

43
Q

Activation of Neural Stretch Receptors in Large Veins –>

A

Signals Pituitary to regulate AVP –> NK2C channels in ThickAL

44
Q

2 Effects of NE

A

(1) Inc Aff and Eff arteriolar tone -> Dec GFR; (2) Inc Na, H20 reabsorption by proximal tubule

45
Q

Direct effect of Angiotensin II

A

Inc Na, H2O reabsorption by proximal tubule

46
Q

How long does it take to restore balance after 1 L of isotonic saline ingested

A

2-4 days

47
Q

More severe increase in ECFV causes

A

Pulmonary Edema

Renal (31 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions