05.05 - Homeostasis (Rao) - Lecture, no reading Flashcards

1
Q

Formula for Plasma Osmolarity

A

(2 x Na mM) + (Glucose mOsm) + (Urea mOsm)

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2
Q

Major cation in ICF

A

K+

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3
Q

What happens to normal RBC when placed in solution of Low Pna and High Glycerol

A

Initially shrinks, then swells

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4
Q

Probes for Total Body Water

A

2H2O, 3H2O, Antipyrene

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5
Q

Major extracellular anion

A

Cl-

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5
Q

Is Cl- greater in plasma or interstitial fluid

A

Greater in interstitial fluid (Gibbs Donnan Effect)

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5
Q

Formula for BV

A

BV= PV/(1-Hct)

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6
Q

Probe for measuring ECFV

A

Inulin, Thiosulfate, Na+

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8
Q

Major cation in ECF

A

Na+

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9
Q

Is HCO3- greater in ICV or ECV

A

ECV

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9
Q

Is PO4+ greater in ICV or ECV

A

ICV

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10
Q

How does Infusion of Isotonic Salt Solution change ECF and ICF

A

Increase ECF, no change in ICF

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11
Q

Formula for ICF

A

ICF = TBW - ECF

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12
Q

Is SO4+ greater in ICV or ECV

A

ICV

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12
Q

Permeability of Na, Urea, Water, Glycerol across PM

A

Im, Per, Per, Slowly permeable

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14
Q

What causes Gibbs Donnan Effect?

A

Proteins impermeable to PM - Anionic so bind Na in plasma and repel Cl- into interstitial fluid

16
Q

Is Cl greater in ICV or ECV

16
Q

How do you correct for filtration/excretion in calculating ECF

A

Subtract excreted value from numerator

17
Q

Ca2+ in ICF vs ECF

A

None in ICF

18
Q

Is Na greater in plasma or interstitial fluid

A

Plasma (Gibbs Donnan Effect)

19
Q

Formula for ISF (interstitial)

A

ISF = ECF - PV

21
Q

What percent of Blood is plasma vs rbc

A

60% plasma, 40% rbc

21
Q

If probe is metabolized, will it over or underestimate the volume

A

Overestimate

23
Q

What to look for when elevated Osmolarity Gap

A

Missing Osmotic particle

24
2 Major anions in ECF
Cl-, HCO3
25
3 Major anions in ICF
Protein, Bicarb, Phosphate
27
If probe is synthesized, will it overestimate or underestimate volume?
Underestimate
28
What Osmolarity gap is abnormal
\>10
29
What percent of water intake is from food + drink
88%
30
Is Mg greater in ICV or ECV
ICV
31
What percent of TBW is BV
8%
32
Formula for PV with probe
PV = Q / Conc.
33
Why is Inulin good probe for ECFV
Smaller than Albumin, can diffuse across capilary wall but not PM
34
Probe for measuring PV
131 I-Albumin, Evans blue dye