0317 - Bacteria in the Body - EG

Question 1

What virulence factor plays a key role in gaining entry?

Answer 1

ahesins - coordinate binding of the organism to a host tissue

Question 2

List some virulence factors of bacterial pathogens.

Answer 2

adhesinsinvasinsimpedinsaggressinsmodulins

Question 3

List some host molecules that act as receptors for bacterial adhesins and the type of interactions they form.

Answer 3

Host Receptors:- glycoproteins, glycolipids, phospholipids- ECM- transmembrane proteins- receptors for cytokines/hormonesTypes of binding:- hydrophonic interactions- cation bridging- specific ligand-receptor interaction

Question 4

What bacterial factors are involved in adhesion?

Answer 4

Gram +’ve -‘ve:- polysaccharidesGram +’ve:- lipotechoic acid- cell wall peptidoglycanGram -‘ve:- lipopolysaccharide- flagella

Question 5

List some mechanisms of dissemination of bacterial pathogens.

Answer 5

• physical trauma- inter- and intra- cellular spread- infection of macrophages and spread through lymphatics- haematogenous spread- local and systemic release of bacterial toxins