Zinc Flashcards

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1
Q

zinc is widely distributed in the body and is found in:

A

all tissues and fluids

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2
Q

sources of zinc

A

shellfish, beef, red meat, nuts, legumes

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3
Q

zinc is more bioavailable in meat sources or plant sources

A

meat source

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4
Q

why is zinc less bioavailable in plant sources

A

because they are high in phytic acid which inhibits zn aborption

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5
Q

zn first needs to be _____ from aa’s and nucleic acids in the ST and SI

A

hydrolyzed

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6
Q

before it can be absorpbed, zn in hydrolyzed in the ST and SI by :

A

hydrochloric acid
proteases
nucleases

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7
Q

the absorption of zn primarily occurs in the

A

SI

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8
Q

the absorption of zn occurs in what three pathways

A
carrier mediated process  (low intakes)
passive diffusion (high intake)
paracellular absorption (high intake)
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9
Q

factors that enhance zn aborption

A

citric acid
picolinate
prostaglandins
low zinc status

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10
Q

factors that inhibit zinc absorption

A

phytates
oxalates
polyphenols
Fe, Ca, Mg

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11
Q

once absorbed the intestinal cell can do three things with zinc:

A

used
stored as metallotionein
transported by Znts to blood

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12
Q

CRIP transports Zn within the ____ of cells

A

cytoplasm

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13
Q

zn in blood is bound to

A

albumin

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14
Q

zn in found in all organs of the body especially

A
liver
kidney
muscle
skin
bone
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15
Q

storage of zinc is usually bound to

A

thionein as metallothionein (binds copper)

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16
Q

functions of zinc

A

growth and dev
immune
neurological function
reproduction

17
Q

the function of zinc can be further divided into three roles

A

catalytic role
structural role
regulatory role

18
Q

the catalytic role of zinc involves over 300 different enzymes such as

A

alcohol/retinol dehydrogenase
carboxypeptidase A and aminopeptidase
polyglutamate hydrolase
alkaline p hosphatase

19
Q

the structural role of zine is important in the structure of

A

proteins and cell membranes

20
Q

Zinc_____ proteins have been found to regulate gene expression by acting as transcription factors

A

finger

21
Q

zn also plays a role in cell signaling and ha been found to influence :

A

hormone release
insulin release
nerve impulse transmission

22
Q

T or F zin has a role in apoptosis

A

true

23
Q

Zn is requried for _____ differentiation and function

A

t-cell

24
Q

zn is primarily excreted through the____

A

GIT

25
Q

S&S of zn deficency

A
growth retardation
delayed sexual maturation in children
dermatitis
diarrhea
impaired immunity
impaired wound healing
dysgeusia
night blindness
hairloss
white spots on fingernails
26
Q

______ abuse has been associated with severe zn deficiencies

A

chronic alcohol abuse

27
Q

those are higher risk of zn deficiency are

A

premature and low birth weight infants
older breast fed infants with inadequate zn intake
teens
pregnant/lactating women
elderly
those with IBD or severe prolonged diarrhea
strict vegetarians

28
Q

clinical indications for zn supplementation

A

common cold

29
Q

the major consequence of long term consumption of excessive zn is ___ deficiency

A

copper

30
Q

acute zn toxicity sx include

A

metallic taste
h/a
n/v/ bloody diarrhea
abd cramps

31
Q

zinc is required for the conversion of _____ to retinal

A

retinol

32
Q

Ca, Mg and Fe (increase/decrease) Zn absorption

A

decrease

33
Q

NAC may (increase/decrease) zn excretion

A

increase

34
Q

___ and ____ can displace zinc and disrupt normal zn function

A

cadmium and lead

35
Q

assessment of status

A

zinc tally test
serm zinc
RBC
hair zinc, saliva,