Selenium Flashcards
richest source of Se is
meat
why does fish have low bioavailability of Se
mercury content
selenium is absorbed in the
SI
what vitamins enhance the absorption of Se
Vitamin A , C , E
what inhibits the absorption of Se
phytate, heavy metals (mercury)
selenium is bound to various proteins in order to travel through the blood such as ___ , __ and ____
VLDL
LDL
selenoprotein P
selenium concentrates in the
thyroid gland kidney liver heart pancreas muscle
functions of selenium
cofactor in selenium dependent enzymes
immune function
what are the selenium dependent enzyemes
iodothyronine deiodinases (IDI) glutathione peroxidases (GPX) selenoprotein P (SEL P)
most of the biologically active T3 in teh circulation and inside cells is created by the removal of one iodine atom from ____ in a reaction catalyzed by selenium dependeny iodothyronine deiodinase enzymes`
T4
selenium is essenetial for
normal growth
metabolism
SEL P functions as a _______ for selenium
transport protein
SEL P also acts as an ______ that protects endothelial cells from damage by reactive nitrogen species
antioxidant
selenium is excreted in the
urine and feces
selenium homeostasis is maintained by the
kidneys
selenium deficiency related diseases
keshan
keshan beck
keshan dz is a cardiomyopathy that affect young women and children in a selenium def ____
china
keshan beck is characterized by the degeneration of ______
cartilage between joints
keshan beck affects ages
5-13
severe forms of keshan beck may result in
dwarfism
clinical indications for selenium supplementation
HIV AIDS
low levels of plasma selenium have ben associatd wtih a significantly increase risk of death from
HIV
early signs of selenosis (selenium toxicity)
brittle nails
hair loss
dermatitis
death due to acute selenosis results from what?
multiple organ failure
the most freq reported sx of chronic selenosis are
hair and nail brittleness/loss n/v/d skin rashes garlic breath fatigue irritability nervous system abn
selenium deficiency can trigger or worsen hypothyroidism in those with severe _____ deficiency
iodine
asses ____ clippings for Se status
toenail clippings
