Phosphorus Flashcards
the majority of phosphorous in th ebody is found as
PO4
most of the P is located in the
bone
sources of P
dairy, meat, eggs, nuts, coffee, tea, soft drink
the phosphorus n all plant seeds is present in a storage form of phosphate called ____
phytic acid or phytate
why is only 50% of phytat available to humans
because we lack enzymes the liberate phosphorous from phytate
yeasts posses ____
phytate
phosphorous is absorbed in its______ form
inorganic
organically boudn phosphorous is first_____ to remove proteins it is bound to in the stomach and SI
hydrolyzed
absorption of P occurs throughout the ____
small intestines (duo and jeju)
a concentration dependent______ is the primary rout of absorptoin for phosphorous
facilitated diffusion
there is also a calcium satruable sodium dependent, carrier mediated transport system which is stimulated by______
calcitriol (1,25 OH)
phosphorous is transported in what form
inorganic and organic forms
phosphorous is mostly stored in
bone and muscle
functions of phosphorous
structural role energy production cell signalling and enzyme activity regulation pH buffering oxygen availability
phosphorous is a major structural component of ____ in the form of phosphate salt called hydroxyapatite
bone
________ are a major structural component of cell membranes
phospholipids
____ and ____ are long chains of phosphate containing molecules
DNA and RNA (nucleic acids)
all energy production and storage are dependent on phosphorylated compounds such as _____ and creatine phosphate
ATP
phosphorous helps maintain normal pH by actin as one of the bodys most important intracellular _____
buffer
the phosphorous containing molecule 2, 3 diphosphoglycerate binds to ____ in RBCs and affect oxygen delivery to tissues of the body
hemoglobin
phosphorous is excreted in its _______ form primarily in the _____
inorganic
urine
S&S of hypophosphatenia
anemia mm weakness bone pain and softening of bones ( rickets, osteomalacia) peripheral neuropathy severe = death!
who is at risk for hypophosphatenia
alcoholics
diabetes recovering from an episode of diabetic ketoacidosis
people taking very high amounts of antacids
hyperphosphatemia is only usually a problem in people with
end stage renal disease
high phosphate levels in the blood reduce the activation of ____ in the kidneys, reduce blood ____ levels, and lead to _____ release
high phosphate levels in the blood reduce the activation of [ VITAMIN D ] in the kidney reduce blood [calcium ] levels, and lead to [PTH] release
high serum phosphorous lead to decrease urinary ____ excretion
calcium
osteoporosis frequently results in
kyphosis
kyphosis causes
decreased lung capacity SOB abd pain reduced appetite premature satiety
there is an increased risk of osteoporosis in :
the elderly use of certain meds (glucocorticoids, thyroid hormones, antiepileptic, aromatase inhibitors) sedentary liefestyle decreased exposure to estrogen high sodium intake caffeine intake smoking chronic alcohol consumption
Naturopathic treatment of osteoporosis involves dietary supplementation of
vitamin d magnesium phosphorous vitamin d copper strongtioum boron manganese folic acid, b12, b6 proteins
additional naturopathic treatment of osteoporosis includes
weight bearing exercise
low sodium, alcohol, caffeine, soft drinks
hormonal balance
enzyme/buffer balance
