x Micro, 5, Disease Resistance, Immune System Flashcards
Pathology
study of disease
Etiology
cause of disease
Etiological agent
the agent of disease, the “bug
Pathogenesis
the way a disease develops
Infection
invasion of body by microorgs
Infestation
invasion
Symbiosis
relationship btwn hose and micro, living together
3 types of Symbiosis
- Parasitism
- Commensalism
- Mutualism
Virulence
degree of pathogenicity
Microbrial Antagonism
competition btwn microbes
Progress of Disease
Incubation, Latency, Subclinical, Prodromal, Illness, Decline, Convalescence
Clinical Disease
stage when patient begins to show SS
Subclinical Disease
when person sick, but no obvious ss
Communicable Disease
transmitted directly or indirectly from one host to another
Contagious Disease
disease easily spread from one person to another
Noncommunicable Disease
disease not transmitted from one to another
Types of Disease
Endemic
Epidemic
Pandemic
Endemic
.
Epidemic
.
Pandemic
.
Reservoir of infection
sources of infection
Reserve
source of supply
Carrier
had disease and recovered but continues to shed infectious organisms to human carrier
Zoonoses
animal disease spread to human (rabies, lyme)
non-living reservoir
soil/water (botulism, tetanus)
LD50
Dose of microorgs that will kill 50% of hosts
Mucin
sticky protein traps microbes nad diret and protects inner bdy
Ciliary escalator
microbes trapped in mucus transported away from lungs.
Lysozyme
enzyme that breaks down cell wall
Process of Phagocytosis
- Attachment
- Ingestion
- Phagosome (bubble like organelle)
- Lysosome (digestive enzymes)
- Residual Body (indigestible material)
- Egestion (indigestible material expelled)
Opsonization
Microorgs coated by protein to make them more easily phagocytized. (M&Ms)
Body’s natural response to tissue injury
-redness, pain, heat, swelling, loss of fx
Inflammation process
- Vasodilation
- Chemicals (histamines, kinins, prostaglandins, leukotriens)
- Margination (walling off localized infection))
- Adhesion (leukocytes adhere to endothelial cells in response to cytokines)
- Migration (neutrophils, monocytes, macrophage into tissue)
- Tissue Repair (stroma or parenchyma produce new cells)
Chemicals released by Inflammatoin
- Histamine
- Kinins
- Prostaglandins
- Leukotrienes
Haptens
little bad guys
5 classes of Antibodies
IgM - 1st to appear (First responders, EMT)
IgG - 2nd common (lasting immun)
IgA - in external secretions, mucus, tears, GI etc (wet/sticky)
IgD - very small amount on B-Lyphocyte (sensor)
IgE - Allergy
Active Immun
your body makes it
Natural Active
you naturally got pox and body made antibodies
Artificial Active
vaccine
Passive Immun
you don’t make anti. you receive from outside source.
Natural Passive
mom –> baby
Artificial Passive
Antibody from outside. (rabies shot)
Attenuated Vaccine
LIVE
4 types of Hypersensititivity
1,2,3, - Immediate
4- delayed
1 - anaphylactic
2 - Cytotoxic
3 - Imm Complex Hypersensitivity
4 - Hypersensitivity