wrong u//a Flashcards
what happens to LV CO, SVR, LA filling in a PDA
CO, LA filling increases( cuz there’s more blood being dumped intoLA from pulmoary art) SVR DECREASES
what Ig does the Rh-mom get during prego w/Rh+ baby
IgG(although it crosses the placenta it does NOT cause significant hemolysis cuz the amt is not that much
GAS gangrene is specific to what bacteria
C. Perfringens
C.Perfringens causes gas gangrene how?
due to phosphilipase C. which splits host phopholipids and causes cell lysis & tissue necrosis
M3 causes you to pee through detrusor?
CONTRACTION
which receptor promotes activation of NO
M3(activate GMP—myosin light chain phosphotase(DEPHOSPHORYLATES myosin)-prvnts interaction of myosin w/actin =SM relaxation
which nerves/art are located in the cavernous sinus
III, IV, V1 V2 VI ICA
Aneurysm of the ICA in the cavernous sinus can effect which CN
VI causing weakness of LR6
what describes Ehrlichia Chaffeensis in blood microscopic
mulberry-shaped, intracytoplasmic inclusion in monocytes
B thalasemia effect what type of formation
mRNA(translation, transcription, processing)
Duchenne causes what types of mutations
NONSENSE/FRAMESHIT(MC)
What are the stop codons
UAA, UGA, UAG(NONSENSE MUTATIONS)
what is cryptorchidism
Testes that hv not descended to the scrotum. in ab
to fix Cryptochordism you must pass thru what
aponeurosis of EXTERNAL oblique
Propionyl-Coa is derived from what AA
Threonine, Isoleucine, Methionine, Valine & odd chain fatty acids
Propionyl-CoA carboylase is responsible for the conversion of what
Propionyl-CoA—–Methylmalonyl-CoA
what are the Typical High potency antipsychotics
Haloperidol, Trifluoperazine Fluphenazine (Hal Tries to Fly High)
what are SE of High potency antipsychotics
EPS(dystonia, akathasia, parkinsonism)
shaving, shirt collar, putting on a tie can cause the carotid baroreceptor to do what
increase PARASYMPA(syncope decrease SVR) cuz it thinks high BP
injury to the deep radial nerve can effect what muscle/what occupations
Supinator muscle (repetitive pronation/supination) frequent screwdriver use mechanics
what does elevated BP cause aortic barorecptors to do
causes stretching so aortic baro decreases sympa
what is decreased in serum sickness
C3 type III hypersensivity
manifestations of serum sickness
fever, pruitic rash, arthralgias 7-14 days after exposure to antigen
drugs that can cause serum sickness
Rituximab, infliximab(TNF-a) crohns. Venons, Serum like rxn drugs (pen, cefaclor, TMP-SMX)
what would histo show of serum sickness
fibrinoid necrosis/neutrophils
where does Isotype switching occur
GERMINAL CENTERS!!!!!!!!
what causes Bacillary Angiomatosis
Bartonella Henselae(cat scratch) similar to Kaposi sarcoma
what labs are diagnositc for Hereditary spherocytocis
Decrease mean fluorescene of RBC in EMA, Increase fragility in Osmotic fragility test
what is the purpose of Telomeres
they cause apoptosis thru shortened telomers after maximum LIMIT of proliferation. anything after that limit goes to apoptosis.
what’s the level of telomeres in cancer cells
it’s high because Telomeres protect chrom from being recognized as damaged DNA
prostate metastasise to bone will show what on histo
irregular glands w/enlarged nuclei & prominent nucleoli
pericarditis due to malignancy(breast) will show what in a pericardiocentesis
Hemorrhagic fluid w/ atypical cells
Purpura, Petechiae, Echymoses are a sign on what type of defect
PLATELETS
what forms PLATELETS
MEGAKARYOCYTES
what diz u’ll see MEGAKARYOCYTES
TTP, HUS, Bernard soulier
MOA of Aspirin in plt aggregation
irreversibly blk COX(TX A2 is md from cox which calls in others to aggregate
what is the end product of the coag cascade
THROMBIN
Factor problems causes bleeding where?
muscles & joints rebeleding after surgery wisdom tooth extractions
what kind of bleeding will you see in vWF(VIII) & what test will be abnormal
skin /mucosal bleeding abnormal ristocetin test INCREASE BT/PTT
what’s the MC of inherited hypercoag state
mutated factor V leiden. does NOT hv cleavage site for protein C & S to cleave it
what will you see in mom’s lungs that had PE due to delivery
squamous cells/keratin debris
what are the nerves that DVT usually arise from
femoral, illiac popliteal
why is PE clinically silent
cuz lung has dual blood supply pulmonary art/ bronchile art (coming from aorta)
how does A-fib cause thrombosis
the heart is out of rythym so blood is stasis=coag
if you lack sarcolemmal transverse tubules what will happen
impaired synchronization of cross-bridge formation
what’s the MC of stress incontinence
Urethral hypermobility/ wknd pelvic floor
what’s the ABG for an ACUTE opiod overdose
respiratory acidocis w/ NORMAL HCO3(it’s acute so compensation has not occured yet)
PI(HIV) end in what
NAVIR(indinavir)
what’s the problem in Keloid
increase production in hyalinized collagen(III &I)
what’s the problem in hypertrophic scars
Ecess formation of organized extracellular matrix(III)
where can u find Actinic Keratosis/increase risk of what cancer
Hand, scalp, face ears. squamous (if scrapes off it comes bk in few days) midly pruitic VS Lichen whose severly itchy
what does Vaccination decrease
prevalence-positive predictive value
proliferation of donor T lymphocyte is what type of rejection
Graft VS hOST(rash, dia, jaundice, hepato)
what bone cancer is ass w/ pagets
OSTEOSARCOMA
Does Pure Teratoma hv increase in testicular tumor markers
NO
Burkitt lymphoma has what pattern
Starry sky
Reed steinberg cells owel eye are found in what
HODGKIN LYMPHOMA CD 15, 30
DOC for Stents /SE
Ticlopidine(ADP inhib) NEUTROPENIA/AGRANULOCYTOSIS, GI, rash, pruitis, anaphylais
SE of Hydroyurea and what cycle does it work
Macrocytosis/S phase
stress incontinence is caused by what muscle/nerve
Levator ani(pelvic floor muscle), external Urethral sphincter S2-S4 PUDENDAL
