uworld/amboss

Question 1

what is Drug Reaction Eosinophilia Systemic Symptoms(DRESS SYNDROME)

Answer 1

drug rxn 2-8wks after drug exposure. (fever, lymphadenopathy, facial edema) rash

Question 2

drugs that causes DRESS SYNDROME

Answer 2

phenytoin, carbamazepine, allopurinol, sulfasalazine, minocycline, vanco

Question 3

Cutaneous neurofibroma are composed of what cells

Answer 3

Schwann cells

Question 4

Methadone can cause what type of heart problem

Answer 4

Qt prolongation/torsade

Question 5

what’s the cause of normal age related diminished antibody response to infections/vaccinations

Answer 5

Immunosenscense(Decrease PRODUCTION of naive B& T lymphocytes.

Question 6

Mutation in TTN(titin) gene is ass w/ what heart problem

Answer 6

DIALATED CARDIO

Question 7

SS of Dandy walker/ CT

Answer 7

non-communicating HYDROCEPHALUS. on CT lack of VERMIS(blk spot on the bk of the head)

Question 8

what type of saline do you give for hypovolemia/shock

Answer 8

0.9%(normal saline) Lactated ringer solution

Question 9

Symptoms/presentation/microscopy of AVM pts

Answer 9

seisures/headaches. Blood does not pass thru capillary bed. TANGLE of lrg blood vessels in THICKENED walls

Question 10

Osteoprogrin does what to OSTEOCLAST/ RANK-L

Answer 10

inhibs osteoclast/ prevents RANK-L from binding to RANK

Question 11

DOC/MOA for scabies

Answer 11

Permethrin(inhib Na+)

alternative drug Ivermectin(inhib CL-)

Question 12

what nerve is effected when it’s compress due to obesity/tight clothing

Answer 12

Lateral Femoral Cutaneous nerve

Question 13

what’s a value that’s normal in CO poisoning/anemia/polycythemia

Answer 13

partial pressure of O2 in he blood(PO2)

Question 14

what supplies the papillary muscle

Answer 14

RCA-PDA(post. descending art)

Question 15

thru what mechanisim is Vancomycin resistant

Answer 15

Transposition(plasmid encoded) alteration of peptidoglycan synthesis

Question 16

what are the cancers that releases PTHrP

Answer 16

renal, bladder, ovarian, squamous cell of head neck, lung.

PTHrP does NOT simulate 25D to 1,25 so lvls will be low

Question 17

what’s the cause of Anencephaly & what kind of hydramniosis will you see

Answer 17

failure of rostral neuropore to close. Hole in the head(absence of forebrain) cannot swallow (POLYHYDRAMNIOSIS)

Question 18

Sudden painless loss of vision is called/cause

Answer 18

central retina art. occlusion/ thrombosis, vasculitis, fibromuscular dysplasia. Do a carotid art. ultrasonography

Question 19

what respiratory problem can an immature infant hv w/ mechanical ventilation use

Answer 19

BRONCHOPULMONARY DYSPLASIA

Question 20

what’s a SE(ion) of albuterol

Answer 20

HYPOKALEMIA

Question 21

where is Hormone sensitive lipase found

Answer 21

adipose mobilized triglycerides in FFA /glycerol. FFA to acetyl-coA=Ketone bodies(gluconeogenesis)

Question 22

describe orphan Annie eye/what cancer

Answer 22

Lrg cell w/ nuclei containg finely dispersed chromatin/intranuclear inclusions. PAPILLARY CARCINOMA (MC)

Question 23

what contributes to the Hyperglycemia in glucocorticoids use

Answer 23

increase in epression of liver enzymes(gluconeogenesis)

Question 24

what enzyme converts Testosterone to DHT

Answer 24

5a reductase

Question 25

how does pts w/5a reductase def present

Answer 25

Phenotypically/karyotipically male but FEMALE external(sml phallus,hypospadias)

Question 26

SYMPTOMS OF VIPOMA

Answer 26

Watery Dia, Achylodria, Hypokalemia

Question 27

what does Radioactive Iodine uptake measures(RAIU)

Answer 27

Organification of Iodine & synthesis of NEW (ENDOGENOUS) thyroid hormone

Question 28

what’s the level of RAIU inEXOGENOUS (hypothyroid drugs prescriptions)

Answer 28

Low because RAIU measures ENDOGENOUS thyroid

Question 29

what’s the level of RAIU in Gaves

Answer 29

INCREASE cuz ur mkng the Thyroid hormone

Question 30

What’s the levels for GnRH, LH, Testosterone in a prolactinoma

Answer 30

all decrease Tumors don’t follow -fdbk

Question 31

what is the Na+ level in Hyperaldosteronism(conn syndrome)

Answer 31

Normal due to aldosterone escape but HYPOKALEMIA/METABOLIC ALKALOSIS