Written Prep - Respiratory

Question 1

Asthma - Epidemiology

Risk factors for Asthma (7)

Answer 1

• Atopy
• Genetic Predisposition
• Diet
• Obesity
• Occupational Exposure
• Maternal factors
• Other (Paracetamol use in childhood)

Question 2

Asthma - Epidemiology

Risk Factors: What characteristic do the proteins that predispose to asthma have?

Answer 2

The proteins usually have protease activity

Question 3

Asthma - Epidemiology

Risk Factors:

Atopy: What are the 5 most common allergens?

Answer 3

1. Dermatophagoides
2. Cat and dog fur
3. Coackroaches
4. Grasses + Pollens
5. Rodents

Question 4

Asthma - Epidemiology

Risk Factors:

Genetic Predisposition: What are the 3 aspects to genetic predisposition?

Answer 4

1. Polymorphic gene predisposition associated with Chromosome 5
2. Novel gene associations: ADAM-33 and DPP-10
3. Arg-Gly-16 variant of Beta2-receptor associated with reduced response to beta-agonists

Question 5

Asthma - Epidemiology

Risk Factors:

Diet: What are the (4) diet associations?

Answer 5

1. Some association with diets low in Vitamin C, Magnesium, Vitamin A, Selenium and Vitmain D
2. Assoc. with low Omega-3-polyunsaturated fats
3. Assoc. with high Omega-6-polyunsaturated fats
4. Assoc. with high sodium

Question 6

Asthma - Epidemiology

Risk Factors:

Obesity: how is obesity a risk factor?

Answer 6

• Independent risk factor, especially in women
• Usually asthma is more dificult ot control

Question 7

Asthma - Epidemiology

Risk Factors:

Occupational Exposure

Answer 7

10% of young adults have an occupational exposure

Question 8

Asthma - Epidemiology:

Risk Factors:

What are the (4) maternal risk factors

Answer 8

• Lower maternal age
• Shorter duration of breast feeding
• Prematurity
• Low birthweight