Infectious Diseases - Hep C Treatment

Question 1

Definition of Sustained Virologic Response

Answer 1

Undetectable HCV RNA at 6 months after treatment completed

Question 2

Benefits of achieving a sustained virological response

Answer 2

• improved patient outcomes
• decreased all cause mortality
• decreased HCC
• decreased liver related mortality
• decreased liver transplantation
• decreased liver failure

Question 3

What are the NS3/4A inhibitors

How are they predominantly cleared?

Answer 3

Simeprevir
Paritaprevir
Grazoprevir

HEPATIC CLEARANCE

Question 4

What are the NS5A inhibitors?

Answer 4

Daclastavir
Ledipasvir
Ombitasvir
Velpatasvir

Question 5

What do the NS5B inhibitors do?

Answer 5

Inhibits NS5B, a RNA dependent RNA Polymerase involved in post translational processing

Question 6

What are the NUCLEOS(t)IDE NS5B inhibitors?

Answer 6

Sofosbuvir

Question 7

What are the NON-NUCLEOS(t)IDE inhibitors?

Answer 7

Dasabuvir

Question 8

Which classes of Hep C treatments are prone to resistance?

Answer 8

Protease
NS5A inhibitors
NON-NUCLEOTIDE NS5B inhibitors

Question 9

What are RASs

And which ones persist the longest

Answer 9

Resistant associated substitutions that create resistance to the direct acting antivirals

NS5A RASs persist much longer than PI RASs

Question 10

Simeprevir

Answer 10

NS3/4A inhibitors

Question 11

Paritaprevir

Answer 11

NS3/4A inhibitors

Question 12

Grazoprevir

Answer 12

NS3/4A inhibitors

Question 13

Daclastavir

Answer 13

NS5A inhibitor

Question 14

Ledipasvir

Answer 14

NS5A inhibitor

Question 15

Ombitasvir

Answer 15

NS5A inhibitor

Question 16

Velpatasvir

Answer 16

NS5A inhibitor

Question 17

Sofosbuvir

Answer 17

NUCLEOS(t)IDE NS5B inhibitor

Question 18

Dasabuvir

Answer 18

NON-NUCLEOS(t)IDE inhibitor

Question 19

How do the NS3/4A inhibitors work?

Answer 19

More genotype 1 specific usually

Inhibit serine protease inhibitor involved in post translational processing and replication