Infectious Diseases - Hep C: General Flashcards
What type of virus is Hep C?
Small enveloped +ve sense stranded RNA
What virus family is Hep C
Flaviviridae family
Which genotypes are most common in Australia?
Genotypes 1 (most common) and 3
Why has Hep C prevalence (NOT INCIDENCE) been increasing?
Aging population with chronic disease
How is Hep C transmitted?
IVDU
Transfusions (PRIOR TO 1990)
Healthcare needlestick (3% risk)
Tattooing/Razors
High risk sexual activity Vertical transmission (ESPECIALLY IF ALSO HIV)
Once acquired Hep C, whar proportion go on to get chronic infection, and cirrhosis
60-85% remain chronic infection
30% of chronic Hep C get cirrhosis
5% of cirrhosis get HCC
Acute Hep C: what increases your risk of acute fulminant hepatic failure?
Coinfection Hep C
When does anti-HCV Ab seroconversion happen?
Ab detected 4-24 weeks after HCV RNA detected
Definition of CHRONIC Hep C
> 6 months of HCV PCR +
And anti-HCV Ab +
Risk Factors for Cirrhosis in HCV
Alcohol
Obesity
Diabetes
Underlying liver disease
Extra-Hepatic Manifestations of HCV
HAEM
- mixed cryoglobulinaemia (Cryoglobulinaemia Type II)
- cryoglobulinaemic vasculitis
MEMBRANOPROLIFERATIVE GN
SKIN
- Porphyria cutanea tarda
- Lichen planus
ENDOCRINE
- thyroid dysfunction
- diabetes
RHEUM
- sjogrens
- polyarthritis
Haem manifestations of HCV
- mixed cryoglobulinaemia (Cryoglobulinaemia Type II)
- cryoglobulinaemic vasculitis
Renal manifestation of HCV
Membranoproliferative GN
Skin manifestations of HCV
SKIN
- Porphyria cutanea tarda
- Lichen planus
Endocrine manifestations of HCV
ENDOCRINE
- thyroid dysfunction
- diabetes
