Cardiology - Heart Failure: Chronic Management Flashcards

1
Q

What is Stage A Heart Failure?

A

Stage A = at risk BUT no structural disease or symptoms

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2
Q

What is Stage B Heart Failure?

A

Stage B = Structural disease BUT no symptoms

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3
Q

What is Stage C Heart Failure?

A

Stage C = structural disease WITH previous or current symptoms

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4
Q

What is Stage D Heart Failure?

A

Refractory heart failure requiring specialist interventions with marked symptoms at rest despite maximum medial therapy

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5
Q

ACEi benefit?

A

Reduces mortality
Reduces hospitalisation

(has never been studied in symptomatic hypotension)

NO CHANGE TO SCD

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6
Q

ACEi plus beta blocker versus ACEi alone

A

Better to use lower dose ACEi plus beta blocker than either alone
- additional 35% mortality benefit if beta blocker added

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7
Q

Which ARBs have trial evidence in heart failure?

A

Losartan
Valsartan
Candesartan

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8
Q

Which ARB has been looked at in EF >40% (HFpEF)

A

Candesartan

  • TREND to decreased CV deaths
  • REDUCED hospitalisation for HF
  • REDUCED new diabetes
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9
Q

What salt restriction should HF patients be on?

A

<2g per day of salt

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10
Q

Which beta blockers have been studied in heart failure?

A

Carvedilol
Bisoprolol
Nebivolol
Metoprolol succinate

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11
Q

Which is the most cardioselective beta blocker?

A

Nebivolol

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12
Q

Which beta blocker has evidence for reducing sudden cardiac death?

A

Bisoprolol

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13
Q

Which beta blocker has been studied in seniors?

A

Nebivolol

in patients >70yrs with HFrEF

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14
Q

Role of aldosterone antagonists in HFrEF?

A

Spironolactone in HFrEF <35% (mortality and hospitalisation and symptom benefit)

Eplerenone in EF<35% NYHA Class II reduced mortality and hospitalisation

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15
Q

What side effects of aldosterone antagonists in HFrEF

A

1 in 10 gynecomastia

Increased hyperkalaemia BUT study with eplerenone showed no increase in hospitalisations due to hyperkalaemia

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16
Q

Which aldosterone antagonist would you use post MI and when?

A

Eplerenone in patients 3-14 days post acute MI with LVEF <40%

  • reduced mortality
  • reduced SCD
  • increased hyperkalaemia
17
Q

Role of aldosterone antagonists in HFpEF?

A

Spironolactone in EF>45%

  • reduced HOSPITALISATIONS for HF
  • no change to mortality
  • increased hyperkalaemia and AKI

Spironolactone in EF >50%
- improved echo measures of diastolic dysfunction but no other changes

18
Q

Mechanism of hydralazine plus nitrates in heart failure?

A

Hydralazine: direct smooth muscle relaxation causing systemic peripheral vasodilation

Nitrates: in smooth muscle cells nitrates are transformed to nitric oxide which stimulates cGMP production and therefore vasodilation

19
Q

Role for hydralaxine plus nitrates in heart failure?

A

IN African Americans has mortality benefit, hospitalisation benefit and improved QoL

20
Q

Ivabradine role in heart failure?

A

Alters SINUS node rate
Inhibits If channels in SINUS NODE and RETINA

If LVEF <35%, symptoms and a sinus rhythm >77bpm has mortality benefit but only is ADEQUATE beta blockage dose or unable to use beta blocker

21
Q

Where are the If receptors found?

A

Sinus node and retina

22
Q

Role of digoxin in heart failure?

A

Mild inotropic effects
Attenuates carotid sinus baroreceptor activity
Sympathoinhibitory
Reduces plasma renin and reduces noradrenaline levels

In LVEF <45% improves hospitalisation but not mortality or QoL

23
Q

Mech of neprolysin inhibitors?

A
Degrades natriuretic peptides (ie BNP, bradykinin, CNP and Substance P)
Which causes: 
- Diuresis
- Natriuresis
- Vasodilation
- Decreased fibrosis and hypertrophy
24
Q

Why does neprolysin need to be added to RAAS blockade?

A

Neprolysin also breaks down Angiotensin I and II
–> neprolysin inhibition will therefore increase levels of angiotensin II which counteracts the other benefits of it

So you need to combine with an ARB

25
Q

Benefit of Neprolysin Inhibitors?

A

In HFrEF <40%

  • reduced CVS mortality
  • reduced HF hospitalisation
26
Q

Role of fish oil in HF?

A

Long chain omega 3 polyunsaturated fatty acids have associated with modest improvement in outcomes and HFrEF mortality

27
Q

Role for thiamine in HF?

A

Selenium and thiamine deficiency lead to HF

Some SMALL evidence for thiamine in chronic HFrEF

28
Q

Role of Graded External Pneumatic Compression (Enhanced External Counterpulsion) (EECP)

A
  • improved ET and QoL
29
Q

Role of exercise in HFrEF?

A

Improved QoL
No adverse outcomes
TREND to mortality reduction
Improved peak O2 consumption at 12 months

30
Q

Indications for biventricular pacing in HF?

A
  • NYHA Class III-IV
  • NYHA Class II with LBBB QRS >150ms
  • LBBB QRS >120ms (BEST evidence if >150)
  • EF <35% with ischaemic or dilated CM
  • on guideline maxmum medical therapy
  • sinus rhythm

MORTALITY BENEFIT

31
Q

Indications for ICD in HF?

A
  • NYHA II-III with LVEF <35%
  • Post MI with EF <30% at >40 days post MI
  • Post CABG with LVEF <30% and >3 months post CABG
32
Q

Role of CABG for HF?

A

Best role for ongoing angina in ischaemic cardiomyopathy with multivessel disease

  • no change to all-cause mortality
  • reduced CV-death and reduced COMBINED all-cause mortality+hospitalisation