Cardiology - Heart Failure: Chronic Management Flashcards
What is Stage A Heart Failure?
Stage A = at risk BUT no structural disease or symptoms
What is Stage B Heart Failure?
Stage B = Structural disease BUT no symptoms
What is Stage C Heart Failure?
Stage C = structural disease WITH previous or current symptoms
What is Stage D Heart Failure?
Refractory heart failure requiring specialist interventions with marked symptoms at rest despite maximum medial therapy
ACEi benefit?
Reduces mortality
Reduces hospitalisation
(has never been studied in symptomatic hypotension)
NO CHANGE TO SCD
ACEi plus beta blocker versus ACEi alone
Better to use lower dose ACEi plus beta blocker than either alone
- additional 35% mortality benefit if beta blocker added
Which ARBs have trial evidence in heart failure?
Losartan
Valsartan
Candesartan
Which ARB has been looked at in EF >40% (HFpEF)
Candesartan
- TREND to decreased CV deaths
- REDUCED hospitalisation for HF
- REDUCED new diabetes
What salt restriction should HF patients be on?
<2g per day of salt
Which beta blockers have been studied in heart failure?
Carvedilol
Bisoprolol
Nebivolol
Metoprolol succinate
Which is the most cardioselective beta blocker?
Nebivolol
Which beta blocker has evidence for reducing sudden cardiac death?
Bisoprolol
Which beta blocker has been studied in seniors?
Nebivolol
in patients >70yrs with HFrEF
Role of aldosterone antagonists in HFrEF?
Spironolactone in HFrEF <35% (mortality and hospitalisation and symptom benefit)
Eplerenone in EF<35% NYHA Class II reduced mortality and hospitalisation
What side effects of aldosterone antagonists in HFrEF
1 in 10 gynecomastia
Increased hyperkalaemia BUT study with eplerenone showed no increase in hospitalisations due to hyperkalaemia